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ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538



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macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CARMIL1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:23,268,438...23,581,794
Ensembl chr35:23,268,723...23,581,403
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:18003703 RGD:9685165 NCBI chr20:50,398,866...50,487,303
Ensembl chr20:50,398,864...50,487,241
JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:41,779,950...42,177,957
Ensembl chr 4:41,780,436...42,235,177
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:5,873,088...5,903,484
Ensembl chr 7:5,814,201...5,902,220
JBrowse link
G MAPKAPK3 MAPK activated protein kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:38,731,492...38,759,000
Ensembl chr20:38,732,397...38,758,494
JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240
JBrowse link
G RAB34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) UniProt PMID:17881736 NCBI chr 9:42,909,843...42,913,935
Ensembl chr 9:42,910,011...42,913,985
JBrowse link
G SNX33 sorting nexin 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:38,441,311...38,453,477
Ensembl chr30:38,441,305...38,450,161
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:33,123,577...33,166,831
Ensembl chr20:33,130,723...33,166,792
JBrowse link
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:33,192,261...33,243,034
Ensembl chr10:33,191,602...33,242,669
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17880
    cellular process 16922
      vesicle-mediated transport 1644
        endocytosis 719
          pinocytosis 25
            macropinocytosis 10
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 0
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 2
Path 2
Term Annotations click to browse term
  biological_process 17880
    localization 5576
      establishment of localization 4868
        transport 4541
          vesicle-mediated transport 1644
            endocytosis 719
              pinocytosis 25
                macropinocytosis 10
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 0
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 2
paths to the root