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ONTOLOGY REPORT - ANNOTATIONS


Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538


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macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:19846667) UniProt PMID:19846667 NCBI chrNW_004955483:1,463,856...1,770,798
Ensembl chrNW_004955483:1,463,805...1,770,520
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:18003703 RGD:9685165 NCBI chrNW_004955495:1,860,644...1,934,589
Ensembl chrNW_004955495:1,860,644...1,934,818
JBrowse link
G Dock2 dedicator of cytokinesis 2 involved_in ISO (MGI:5291858|PMID:21892172) UniProt PMID:21892172 MGI:5291858 NCBI chrNW_004955408:22,630,375...23,059,832
Ensembl chrNW_004955408:22,630,364...23,059,899
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chrNW_004955406:42,231,858...42,276,477
Ensembl chrNW_004955406:42,231,858...42,276,477
JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 involved_in ISO (MGI:3761050|PMID:17906627) UniProt PMID:17906627 MGI:3761050 NCBI chrNW_004955532:2,392,539...2,419,219
Ensembl chrNW_004955532:2,392,539...2,420,604
JBrowse link
G Rab34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) UniProt PMID:17881736 NCBI chrNW_004955481:4,441,290...4,445,969
Ensembl chrNW_004955481:4,441,407...4,445,969
JBrowse link
G Snx33 sorting nexin 33 involved_in ISO (PMID:21048941) UniProt PMID:21048941 NCBI chrNW_004955450:2,669,993...2,682,503
Ensembl chrNW_004955450:2,669,993...2,682,503
JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chrNW_004955430:6,986,977...7,018,938
Ensembl chrNW_004955430:6,986,759...7,018,938
JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021) UniProt PMID:27219021 MGI:6270783 NCBI chrNW_004955405:39,503,020...39,540,069
Ensembl chrNW_004955405:39,503,020...39,540,335
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12326
    cellular process 11511
      vesicle-mediated transport 1218
        endocytosis 566
          pinocytosis 23
            macropinocytosis 9
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 0
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 2
Path 2
Term Annotations click to browse term
  biological_process 12326
    localization 4253
      establishment of localization 3592
        transport 3319
          vesicle-mediated transport 1218
            endocytosis 566
              pinocytosis 23
                macropinocytosis 9
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 0
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 2
paths to the root