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ONTOLOGY REPORT - ANNOTATIONS

Term:macropinocytosis
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Accession:GO:0044351 term browser browse the term
Definition:An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
Synonyms:broad_synonym: clathrin-independent pinocytosis
 related_synonym: single-organism macropinocytosis
 alt_id: GO:1902538


show annotations for term's descendants           Sort by:
macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:19846667) RGD PMID:19846667 NCBI chr17:40,807,921...41,088,326
Ensembl chr17:40,808,389...41,088,326 		JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:18003703 RGD:9685165 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157 		JBrowse link
G Dock2 dedicator of cytokinesis 2 involved_in ISO (MGI:5291858|PMID:21892172) RGD PMID:21892172 MGI:5291858 NCBI chr10:18,827,237...19,244,832
Ensembl chr10:18,827,239...19,244,808 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 involved_in ISO
IEA		 (PMID:24591580)
GO_REF:0000107		 RGD
Ensembl		 PMID:24591580 GO_REF:0000107 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO (MGI:3761050|PMID:17906627)
(PMID:17906627)		 RGD PMID:17906627 MGI:3761050 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17906627)
(MGI:3761050|PMID:17906627)		 UniProt
RGD		 PMID:17906627 GO_REF:0000024 MGI:3761050 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (MGI:5291858|PMID:21892172)
(PMID:21892172)		 RGD PMID:21892172 MGI:5291858 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rab34 RAB34, member RAS oncogene family NOT|involved_in ISO (PMID:17881736) RGD PMID:17881736 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538 		JBrowse link
G Snx33 sorting nexin 33 involved_in ISO (PMID:21048941) RGD PMID:21048941 NCBI chr 8:57,315,861...57,328,522
Ensembl chr 8:57,317,161...57,327,538 		JBrowse link
negative regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stx1b syntaxin 1B involved_in ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280 		JBrowse link
positive regulation of macropinocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 involved_in ISO (MGI:6270783|PMID:27219021) RGD PMID:27219021 MGI:6270783 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692 		JBrowse link
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:6270783|PMID:27219021)
(PMID:27219021)		 RGD PMID:27219021 MGI:6270783 NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      vesicle-mediated transport 1638
        endocytosis 735
          pinocytosis 25
            macropinocytosis 12
              extracellular exosome macropinocytosis 0
              negative regulation of macropinocytosis 1
              positive regulation of macropinocytosis 2
              regulation of macropinocytosis + 3
Path 2
Term Annotations click to browse term
  biological_process 20134
    localization 5690
      establishment of localization 4993
        transport 4686
          vesicle-mediated transport 1638
            endocytosis 735
              pinocytosis 25
                macropinocytosis 12
                  extracellular exosome macropinocytosis 0
                  negative regulation of macropinocytosis 1
                  positive regulation of macropinocytosis 2
                  regulation of macropinocytosis + 3
paths to the root