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Term:endoplasmic reticulum quality control compartment
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Accession:GO:0044322 term browser browse the term
Definition:A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.
Synonyms:exact_synonym: ER quality control compartment;   ERQC
 related_synonym: ER-derived quality control compartment

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endoplasmic reticulum quality control compartment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asgr2 asialoglycoprotein receptor 2 ISO (PMID:11408579) RGD PMID:11408579 NCBI chr10:56,710,446...56,723,608
Ensembl chr10:56,710,464...56,723,611
JBrowse link
G Calr calreticulin ISO (MGI:6120598|PMID:11408579) RGD PMID:11408579 MGI:6120598 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Canx calnexin ISO (MGI:6120598|PMID:11408579) RGD PMID:11408579 MGI:6120598 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Derl1 derlin 1 ISO (MGI:6467686|PMID:23233672) RGD PMID:23233672 MGI:6467686 NCBI chr 7:97,737,176...97,759,852
Ensembl chr 7:97,737,178...97,759,852
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 IEA
PMID:23233672 GO_REF:0000108 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edem2 ER degradation enhancing alpha-mannosidase like protein 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:151,232,741...151,258,559
Ensembl chr 3:151,232,751...151,258,580
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:6467680|PMID:17707796) RGD PMID:17707796 MGI:6467680 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 ISO (MGI:6467680|PMID:17707796) RGD PMID:17707796 MGI:6467680 NCBI chr 1:192,126,023...192,142,865
Ensembl chr 1:192,126,023...192,142,854
JBrowse link
G Fbxo6 F-box protein 6 ISO
(MGI:5644019|PMID:21062743), (MGI:6467686|PMID:23233672)
RGD PMID:21062743, PMID:23233672, PMID:21873635 MGI:5644019, MGI:6467686, RGD:13792537 NCBI chr 5:164,956,285...164,962,075
Ensembl chr 5:164,956,280...164,959,851
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO (MGI:6467687|PMID:24478453) RGD PMID:24478453 MGI:6467687 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Man1b1 mannosidase, alpha, class 1B, member 1 ISO (PMID:18003979) RGD PMID:18003979 NCBI chr 3:2,547,259...2,569,051
Ensembl chr 3:2,547,986...2,569,049
JBrowse link
G Rhbdd1 rhomboid domain containing 1 ISS
PMID:22795130 GO_REF:0000024, MGI:5437551 NCBI chr 9:88,110,731...88,229,462
Ensembl chr 9:88,110,731...88,229,479
JBrowse link
G Sec61b SEC61 translocon subunit beta ISO (PMID:17707796)
(MGI:6120598|PMID:11408579), (MGI:6467680|PMID:17707796)
RGD PMID:11408579, PMID:17707796 MGI:6120598, MGI:6467680 NCBI chr 5:63,192,322...63,200,532
Ensembl chr 5:63,192,298...63,200,508
JBrowse link
G Syvn1 synoviolin 1 ISO (PMID:23233672), (PMID:24478453)
RGD PMID:17707796, PMID:23233672, PMID:24478453 MGI:6467680 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20615
    cellular anatomical entity 20304
      endoplasmic reticulum quality control compartment 14
Path 2
Term Annotations click to browse term
  cellular_component 20615
    cellular anatomical entity 20304
      organelle 13278
        membrane-bounded organelle 11263
          intracellular membrane-bounded organelle 10518
            endoplasmic reticulum 1760
              endoplasmic reticulum quality control compartment 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.