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ONTOLOGY REPORT - ANNOTATIONS

Term:response to leptin
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Accession:GO:0044321 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
Synonyms:exact_synonym: response to leptin stimulus


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response to leptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbs2 Bardet-Biedl syndrome 2 acts_upstream_of_or_within ISO MGI:3521669 (PMID:18317593) RGD PMID:18317593 NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3045473 (PMID:18317593) RGD PMID:18317593 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Ccnd1 cyclin D1 involved_in ISO
IEA		 (PMID:17344214)
GO_REF:0000107		 RGD
Ensembl		 PMID:17344214 GO_REF:0000107 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Edn1 endothelin 1 IEP RGD PMID:16144973 RGD:8662327 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fdx1 ferredoxin 1 IEP RGD PMID:11604238 RGD:4145667 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414 		JBrowse link
G Ghrh growth hormone releasing hormone IEP RGD PMID:18806317 RGD:5687187 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:23073237 RGD:13792788 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Lepr leptin receptor involved_in IEP
ISO		 (MGI:2652302|PMID:12594516) RGD PMID:12594516 PMID:18515494 MGI:2652302, RGD:5129110 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in IMP
ISO
IEA		 PMID:17324488
(PMID:17324488)
(MGI:3814816|PMID:17324488)
GO_REF:0000107		 RGD
Ensembl		 PMID:17324488 PMID:17324488 GO_REF:0000107 MGI:3814816, RGD:13210549 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3526444 (PMID:18317593) RGD PMID:18317593 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(MGI:5313784|PMID:22166979)
GO_REF:0000033
GO_REF:0000118		 UniProt
Ensembl
RGD
GO_Central
TreeGrafter		 PMID:22166979 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:5313784 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 IEP RGD PMID:16375900 RGD:9999182 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Sftpb surfactant protein B IEP RGD PMID:11839533 RGD:151667444 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:4821191|PMID:20620997) RGD PMID:20620997 MGI:4821191 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Star steroidogenic acute regulatory protein IEP RGD PMID:11604238 RGD:4145667 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO
ISS		 (PMID:17344214)
GO_REF:0000024
(MGI:2652302|PMID:12594516), (MGI:5700303|PMID:16825198)		 RGD
UniProt		 PMID:12594516 PMID:16825198 PMID:17344214 GO_REF:0000024 MGI:2652302 MGI:5700303 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
cellular response to leptin stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccna2 cyclin A2 IEP RGD PMID:17303663 RGD:2289137 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Fdx1 ferredoxin 1 IEP RGD PMID:10098510 RGD:4145764 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414 		JBrowse link
G Fgb fibrinogen beta chain IEP RGD PMID:17521427 RGD:7175504 NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979 		JBrowse link
G Fgf23 fibroblast growth factor 23 IEP RGD PMID:23263654 RGD:10044209 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Gck glucokinase involved_in IDA PMID:17470517 BHF-UCL PMID:17470517 RGD:8554539 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Inhbb inhibin subunit beta B involved_in IEA
ISO		 GO_REF:0000107
(MGI:4821933|PMID:19491194)		 Ensembl
RGD		 PMID:19491194 GO_REF:0000107 MGI:4821933 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Lep leptin involved_in ISO (PMID:17344214) RGD PMID:17344214 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Nkx2-1 NK2 homeobox 1 IEP RGD PMID:23894445 RGD:12911205 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in ISO
ISS		 (MGI:4353981|PMID:19523439)
GO_REF:0000024		 RGD
UniProt		 PMID:19523439 GO_REF:0000024 MGI:4353981 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (MGI:5308004|PMID:19894142) RGD PMID:19894142 MGI:5308004 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Pten phosphatase and tensin homolog IMP RGD PMID:24103758 RGD:12802338 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17344214)		 UniProt
RGD		 PMID:17344214 GO_REF:0000024 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
leptin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 acts_upstream_of_or_within ISO MGI:3521669 (PMID:19150989) RGD PMID:19150989 NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3045473 (PMID:19150989) RGD PMID:19150989 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Lep leptin involved_in IDA
ISO		 (MGI:5700303|PMID:16825198)
PMID:11677594		 RGD PMID:16825198 PMID:9070213 PMID:11677594 PMID:9618284 MGI:5700303, RGD:2290293, RGD:10448951, RGD:2290294 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor involved_in IDA
IEA
ISO		 GO_REF:0000107
(MGI:2652302|PMID:12594516)
(PMID:27037668)		 Ensembl
RGD		 PMID:12594516 PMID:27037668 PMID:9070213 PMID:9618284 GO_REF:0000107 MGI:2652302, RGD:2290293, RGD:2290294 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lepr_v1 leptin receptor, variant 1 IDA RGD PMID:9070213 PMID:9618284 RGD:2290293, RGD:2290294
G Lepr_v2 leptin receptor, variant 2 IDA RGD PMID:9070213 PMID:9618284 RGD:2290293, RGD:2290294
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3526444 (PMID:19150989) RGD PMID:19150989 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
G Mt3 metallothionein 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5299282|PMID:21726645)		 UniProt
RGD		 PMID:21726645 GO_REF:0000024 MGI:5299282 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:4821191|PMID:20620997)
GO_REF:0000107		 RGD
Ensembl		 PMID:20620997 GO_REF:0000107 MGI:4821191 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:2652302|PMID:12594516), (MGI:5700303|PMID:16825198)
(PMID:17344214)		 UniProt
GO_Central
Ensembl
RGD		 PMID:12594516 PMID:16825198 PMID:17344214 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:2652302 MGI:5700303 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase involved_in ISS
ISO		 GO_REF:0000024
(MGI:5634638|PMID:23554574)		 UniProt
RGD		 PMID:23554574 GO_REF:0000024 MGI:5634638 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393 		JBrowse link
negative regulation of appetite by leptin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbs2 Bardet-Biedl syndrome 2 involved_in ISO (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 involved_in ISO (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr 8:59,731,912...59,765,408
Ensembl chr 8:59,731,912...59,765,607 		JBrowse link
G Lep leptin involved_in IDA
IBA		 PMID:11677594
GO_REF:0000033		 GO_Central PMID:11677594 GO_REF:0000033, RGD:10448951 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mkks MKKS centrosomal shuttling protein involved_in ISO (MGI:3836843|PMID:19150989) RGD PMID:19150989 MGI:3836843 NCBI chr 3:124,201,877...124,221,142
Ensembl chr 3:124,201,877...124,220,162 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      response to endogenous stimulus 2221
        response to hormone 1323
          response to leptin 31
            cellular response to leptin stimulus + 22
Path 2
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      response to chemical 6021
        response to organic substance 3701
          response to hormone 1323
            response to leptin 31
              cellular response to leptin stimulus + 22
paths to the root