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ONTOLOGY REPORT - ANNOTATIONS

Term:organelle membrane contact site
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Accession:GO:0044232 term browser browse the term
Definition:A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
Synonyms:exact_synonym: MCS
 narrow_synonym: inter-organelle junction;   interorganelle junction


show annotations for term's descendants           Sort by:
organelle membrane contact site term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG2A autophagy related 2A is_active_in IDA (PMID:30952800) UniProt PMID:30952800 NCBI chr11:64,894,546...64,917,209
Ensembl chr11:64,894,546...64,917,209 		JBrowse link
G CLSTN3 calsyntenin 3 is_active_in ISS UniProt GO_REF:0000024 NCBI chr12:7,129,093...7,158,945
Ensembl chr12:7,129,698...7,158,945 		JBrowse link
G ESYT2 extended synaptotagmin 2 located_in IDA (PMID:23791178) UniProt PMID:23791178 NCBI chr 7:158,730,997...158,829,509
Ensembl chr 7:158,730,995...158,830,253 		JBrowse link
G ESYT3 extended synaptotagmin 3 located_in IDA (PMID:23791178) UniProt PMID:23791178 NCBI chr 3:138,434,616...138,481,686
Ensembl chr 3:138,434,586...138,481,686 		JBrowse link
G GRAMD1A GRAM domain containing 1A located_in IDA
IEA		 (PMID:29469807) UniProt PMID:29469807 GO_REF:0000117 NCBI chr19:34,994,727...35,026,469
Ensembl chr19:34,994,784...35,026,471 		JBrowse link
G GRAMD1B GRAM domain containing 1B located_in IEA UniProt GO_REF:0000117 NCBI chr11:123,358,422...123,627,767
Ensembl chr11:123,358,428...123,627,774 		JBrowse link
G GRAMD1C GRAM domain containing 1C located_in IEA UniProt GO_REF:0000117 NCBI chr 3:113,828,192...113,947,174
Ensembl chr 3:113,828,182...113,947,174 		JBrowse link
G GRAMD2A GRAM domain containing 2A located_in
is_active_in		 IDA
IBA		 (PMID:29469807) UniProt
GO_Central		 PMID:29469807 GO_REF:0000033 NCBI chr15:72,159,806...72,197,787
Ensembl chr15:72,159,806...72,197,787 		JBrowse link
G MOSPD2 motile sperm domain containing 2 located_in IDA (PMID:29858488), (PMID:35389430) UniProt PMID:29858488 PMID:35389430 NCBI chr  X:14,873,421...14,922,327
Ensembl chr  X:14,873,421...14,922,327 		JBrowse link
G OSBPL1A oxysterol binding protein like 1A located_in IDA (PMID:29858488) UniProt PMID:29858488 NCBI chr18:24,162,045...24,397,824
Ensembl chr18:24,162,045...24,397,880 		JBrowse link
G RMDN3 regulator of microtubule dynamics 3 located_in IDA (PMID:29858488) UniProt PMID:29858488 NCBI chr15:40,735,887...40,755,254
Ensembl chr15:40,735,884...40,755,851 		JBrowse link
G STARD3 StAR related lipid transfer domain containing 3 located_in IDA (PMID:24105263), (PMID:28377464), (PMID:29858488) UniProt PMID:24105263 PMID:28377464 PMID:29858488 NCBI chr17:39,637,144...39,664,201
Ensembl chr17:39,637,090...39,664,201 		JBrowse link
G STARD3NL STARD3 N-terminal like located_in IDA (PMID:24105263), (PMID:29858488) UniProt PMID:24105263 PMID:29858488 NCBI chr 7:38,178,245...38,230,669
Ensembl chr 7:38,178,245...38,230,670 		JBrowse link
endoplasmic reticulum-endosome membrane contact site term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MOSPD2 motile sperm domain containing 2 located_in
is_active_in		 IDA
IBA		 (PMID:29858488) UniProt
GO_Central		 PMID:29858488 GO_REF:0000033 NCBI chr  X:14,873,421...14,922,327
Ensembl chr  X:14,873,421...14,922,327 		JBrowse link
G STARD3 StAR related lipid transfer domain containing 3 located_in
is_active_in		 IDA
IBA		 (PMID:24105263) UniProt
GO_Central		 PMID:24105263 GO_REF:0000033 NCBI chr17:39,637,144...39,664,201
Ensembl chr17:39,637,090...39,664,201 		JBrowse link
G STARD3NL STARD3 N-terminal like located_in
is_active_in		 IDA
IBA		 (PMID:24105263) UniProt
GO_Central		 PMID:24105263 GO_REF:0000033 NCBI chr 7:38,178,245...38,230,669
Ensembl chr 7:38,178,245...38,230,670 		JBrowse link
G TMCC1 transmembrane and coiled-coil domain family 1 located_in IDA (PMID:30220460) UniProt PMID:30220460 NCBI chr 3:129,647,792...129,893,711
Ensembl chr 3:129,647,792...129,893,711 		JBrowse link
endoplasmic reticulum-plasma membrane contact site term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLTP1 bridge-like lipid transfer protein family member 1 located_in ISS UniProt GO_REF:0000024 NCBI chr 4:122,152,331...122,362,752
Ensembl chr 4:122,152,331...122,364,167 		JBrowse link
G BLTP2 bridge-like lipid transfer protein family member 2 located_in ISS UniProt GO_REF:0000024 NCBI chr17:28,614,440...28,645,159
Ensembl chr17:28,614,446...28,645,454 		JBrowse link
G C2CD2L C2CD2 like located_in IDA (PMID:28209843) UniProt PMID:28209843 NCBI chr11:119,102,249...119,118,544
Ensembl chr11:119,102,198...119,118,544 		JBrowse link
G ESYT2 extended synaptotagmin 2 located_in IDA (PMID:27044890), (PMID:30220461) UniProt PMID:27044890 PMID:30220461 NCBI chr 7:158,730,997...158,829,509
Ensembl chr 7:158,730,995...158,830,253 		JBrowse link
G ESYT3 extended synaptotagmin 3 located_in IDA (PMID:30220461) UniProt PMID:30220461 NCBI chr 3:138,434,616...138,481,686
Ensembl chr 3:138,434,586...138,481,686 		JBrowse link
G GRAMD1A GRAM domain containing 1A located_in
is_active_in		 IEA
IBA
ISS		 Ensembl
TreeGrafter
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr19:34,994,727...35,026,469
Ensembl chr19:34,994,784...35,026,471 		JBrowse link
G GRAMD1B GRAM domain containing 1B located_in
is_active_in		 IDA
IBA
IEA		 (PMID:30220461) UniProt
GO_Central
TreeGrafter
Ensembl		 PMID:30220461 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:123,358,422...123,627,767
Ensembl chr11:123,358,428...123,627,774 		JBrowse link
G GRAMD1C GRAM domain containing 1C located_in
is_active_in		 IEA
IBA
ISS		 Ensembl
TreeGrafter
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:113,828,192...113,947,174
Ensembl chr 3:113,828,182...113,947,174 		JBrowse link
G OSBPL5 oxysterol binding protein like 5 located_in IDA (PMID:26206935), (PMID:30220461) UniProt PMID:26206935 PMID:30220461 NCBI chr11:3,087,107...3,165,310
Ensembl chr11:3,087,107...3,166,739 		JBrowse link
G SACM1L SAC1 like phosphatidylinositide phosphatase located_in IDA (PMID:27044890) UniProt PMID:27044890 NCBI chr 3:45,689,396...45,745,409
Ensembl chr 3:45,689,056...45,745,412 		JBrowse link
G SARAF store-operated calcium entry associated regulatory factor located_in IDA (PMID:22464749) UniProt PMID:22464749 NCBI chr 8:30,063,003...30,083,208
Ensembl chr 8:30,063,003...30,083,208 		JBrowse link
G STIMATE STIM activating enhancer located_in IDA (PMID:26644574) UniProt PMID:26644574 NCBI chr 3:52,836,733...52,897,548
Ensembl chr 3:52,836,219...52,897,548 		JBrowse link
mitochondria-associated endoplasmic reticulum membrane contact site term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACSL4 acyl-CoA synthetase long chain family member 4 located_in IDA (PMID:23455425) MGI PMID:23455425 NCBI chr  X:109,641,335...109,733,257
Ensembl chr  X:109,624,244...109,733,403 		JBrowse link
G AHCYL1 adenosylhomocysteinase like 1 located_in IDA (PMID:27995898) UniProt PMID:27995898 NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742 		JBrowse link
G ATG14 autophagy related 14 located_in IEA Ensembl GO_REF:0000107 NCBI chr14:55,366,391...55,411,830
Ensembl chr14:55,366,391...55,411,830 		JBrowse link
G ATG5 autophagy related 5 located_in
is_active_in		 IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G BCAP31 B cell receptor associated protein 31 located_in IDA (PMID:31206022) UniProt PMID:31206022 NCBI chr  X:153,700,492...153,724,387
Ensembl chr  X:153,700,492...153,724,565 		JBrowse link
G BCL2L10 BCL2 like 10 located_in IDA (PMID:27995898) UniProt PMID:27995898 NCBI chr15:52,109,263...52,112,775
Ensembl chr15:52,109,263...52,112,775 		JBrowse link
G CANX calnexin located_in IDA (PMID:23455425) MGI PMID:23455425 NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641 		JBrowse link
G CLCC1 chloride channel CLIC like 1 located_in IDA (PMID:31653868) UniProt PMID:31653868 NCBI chr 1:108,929,505...108,963,484
Ensembl chr 1:108,881,885...108,963,527 		JBrowse link
G FATE1 fetal and adult testis expressed 1 located_in
is_active_in		 IDA
IBA		 (PMID:12865919) UniProt
GO_Central		 PMID:12865919 GO_REF:0000033 NCBI chr  X:151,716,035...151,723,194
Ensembl chr  X:151,716,035...151,723,194 		JBrowse link
G MBOAT7 membrane bound O-acyltransferase domain containing 7 located_in
is_active_in		 IDA
IEA
IBA		 (PMID:23510452) UniProt
TreeGrafter
GO_Central		 PMID:23510452 GO_REF:0000033 GO_REF:0000118 NCBI chr19:54,173,415...54,189,580
Ensembl chr19:54,173,412...54,189,882 		JBrowse link
G PDZD8 PDZ domain containing 8 located_in
is_active_in		 IDA
IBA
IEA		 (PMID:29097544) UniProt
GO_Central
InterPro
Ensembl		 PMID:29097544 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr10:117,277,274...117,375,440
Ensembl chr10:117,277,274...117,375,440 		JBrowse link
G RAB32 RAB32, member RAS oncogene family located_in IDA (PMID:25767741) ParkinsonsUK-UCL PMID:25767741 NCBI chr 6:146,543,833...146,554,953
Ensembl chr 6:146,543,833...146,554,953 		JBrowse link
G RAB38 RAB38, member RAS oncogene family located_in IDA (PMID:25767741) ParkinsonsUK-UCL PMID:25767741 NCBI chr11:87,803,715...88,175,443
Ensembl chr11:88,113,251...88,175,443 		JBrowse link
G SERAC1 serine active site containing 1 located_in IDA (PMID:22683713) UniProt PMID:22683713 NCBI chr 6:158,109,519...158,168,262
Ensembl chr 6:158,109,519...158,168,280 		JBrowse link
G STX17 syntaxin 17 located_in IDA (PMID:23455425) MGI PMID:23455425 NCBI chr 9:99,906,654...99,974,534
Ensembl chr 9:99,906,654...99,974,534 		JBrowse link
G TMEM41B transmembrane protein 41B located_in IDA
IEA		 (PMID:30352685) UniProt
Ensembl		 PMID:30352685 GO_REF:0000107 NCBI chr11:9,280,654...9,314,593
Ensembl chr11:9,280,654...9,314,636 		JBrowse link
G TMX1 thioredoxin related transmembrane protein 1 is_active_in IDA (PMID:22045338), (PMID:27502484) UniProt PMID:22045338 PMID:27502484 NCBI chr14:51,240,247...51,257,655
Ensembl chr14:51,240,162...51,257,655 		JBrowse link
G TMX2 thioredoxin related transmembrane protein 2 located_in
is_active_in		 IDA (PMID:31735293)
(PMID:22045338)		 UniProt PMID:22045338 PMID:31735293 NCBI chr11:57,712,593...57,740,973
Ensembl chr11:57,712,593...57,740,973 		JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 located_in IDA (PMID:23455425) MGI PMID:23455425 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837 		JBrowse link
G TOMM40 translocase of outer mitochondrial membrane 40 located_in IDA (PMID:31206022) UniProt PMID:31206022 NCBI chr19:44,891,254...44,903,689
Ensembl chr19:44,890,569...44,903,689 		JBrowse link
G VPS13A vacuolar protein sorting 13 homolog A located_in IDA (PMID:30093493) UniProt PMID:30093493 NCBI chr 9:77,177,534...77,421,537
Ensembl chr 9:77,177,445...77,421,537 		JBrowse link
G ZFYVE1 zinc finger FYVE-type containing 1 located_in IDA (PMID:23455425) MGI PMID:23455425 NCBI chr14:72,969,445...73,027,106
Ensembl chr14:72,969,451...73,027,131 		JBrowse link
mitochondrial crista junction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOO apolipoprotein O located_in NAS (PMID:25997101) ComplexPortal PMID:25997101 NCBI chr  X:23,833,353...23,907,938
Ensembl chr  X:23,833,353...23,907,938 		JBrowse link
G APOOL apolipoprotein O like located_in NAS (PMID:25997101) ComplexPortal PMID:25997101 NCBI chr  X:85,003,877...85,093,315
Ensembl chr  X:85,003,877...85,093,315 		JBrowse link
G CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 located_in NAS (PMID:25997101) ComplexPortal PMID:25997101 NCBI chr 7:132,784,870...133,082,090
Ensembl chr 7:132,784,870...133,082,090 		JBrowse link
G CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 located_in NAS (PMID:25997101) ComplexPortal PMID:25997101 NCBI chr 3:126,704,240...126,960,420
Ensembl chr 3:126,704,240...126,960,420 		JBrowse link
G IMMT inner membrane mitochondrial protein located_in NAS (PMID:25997101) ComplexPortal PMID:25997101 NCBI chr 2:86,143,936...86,195,462
Ensembl chr 2:86,143,932...86,195,472 		JBrowse link
G MICOS10 mitochondrial contact site and cristae organizing system subunit 10 located_in NAS (PMID:25997101) ComplexPortal PMID:25997101 NCBI chr 1:19,596,979...19,629,820
Ensembl chr 1:19,484,403...19,629,821 		JBrowse link
G MICOS13 mitochondrial contact site and cristae organizing system subunit 13 located_in
is_active_in		 IDA
IBA
NAS		 (PMID:25997101) UniProt
GO_Central
ComplexPortal		 PMID:25997101 GO_REF:0000033 NCBI chr19:5,678,422...5,680,516
Ensembl chr19:5,678,421...5,680,516 		JBrowse link
G MICU1 mitochondrial calcium uptake 1 located_in IDA (PMID:31427612) UniProt PMID:31427612 NCBI chr10:72,367,340...72,626,079
Ensembl chr10:72,367,340...72,626,131 		JBrowse link
mitochondrial inner-outer membrane contact site term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CKMT1B creatine kinase, mitochondrial 1B ISO RGD PMID:1998693 RGD:11565110 NCBI chr15:43,592,857...43,599,406
Ensembl chr15:43,593,054...43,604,901
Ensembl chr15:43,593,054...43,604,901 		JBrowse link
nucleus-vacuole junction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 located_in
is_active_in		 IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:130,678,934...130,746,829
Ensembl chr 3:130,678,934...130,746,829 		JBrowse link
vacuole-isolation membrane contact site term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG16L1 autophagy related 16 like 1 located_in IDA (PMID:28890335) UniProt PMID:28890335 NCBI chr 2:233,251,673...233,295,669
Ensembl chr 2:233,210,051...233,295,674 		JBrowse link
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