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ONTOLOGY REPORT - ANNOTATIONS


Term:organelle membrane contact site
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Accession:GO:0044232 term browser browse the term
Definition:A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.
Synonyms:exact_synonym: MCS
 narrow_synonym: inter-organelle junction;   interorganelle junction


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organelle membrane contact site term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esyt2 extended synaptotagmin 2 ISO (PMID:23791178) RGD PMID:23791178 NCBI chr 6:144,156,021...144,248,374
Ensembl chr 6:144,156,175...144,245,545
JBrowse link
G Esyt3 extended synaptotagmin 3 ISO (PMID:23791178) RGD PMID:23791178 NCBI chr 8:107,555,417...107,602,414
Ensembl chr 8:107,555,277...107,602,263
JBrowse link
G Gramd1a GRAM domain containing 1A ISS
ISO
GO_REF:0000024
(PMID:29469807)
UniProt
RGD
PMID:29469807 GO_REF:0000024 NCBI chr 1:89,563,982...89,590,406
Ensembl chr 1:89,563,976...89,590,490
JBrowse link
G Gramd2a GRAM domain containing 2A ISO
IBA
(PMID:29469807)
PMID:21873635
RGD PMID:29469807, PMID:21873635 RGD:13792537 NCBI chr 8:64,503,058...64,539,149
Ensembl chr 8:64,531,594...64,539,367
JBrowse link
G Mospd2 motile sperm domain containing 2 ISO (PMID:29858488) RGD PMID:29858488 NCBI chr  X:31,140,967...31,182,823
Ensembl chr  X:31,140,960...31,182,816
JBrowse link
G Osbpl1a oxysterol binding protein-like 1A ISO
IEA
(PMID:29858488)
GO_REF:0000107
RGD
Ensembl
PMID:29858488 GO_REF:0000107 NCBI chr18:4,097,011...4,294,136
Ensembl chr18:4,097,012...4,294,136
JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 ISO (PMID:29858488) RGD PMID:29858488 NCBI chr 3:110,943,843...110,964,449
Ensembl chr 3:110,943,826...110,964,452
JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 ISO (PMID:24105263), (PMID:28377464), (PMID:29858488) RGD PMID:24105263, PMID:28377464, PMID:29858488 NCBI chr10:86,313,430...86,335,868
Ensembl chr10:86,313,383...86,335,923
JBrowse link
G Stard3nl STARD3 N-terminal like ISO (PMID:24105263), (PMID:29858488) RGD PMID:24105263, PMID:29858488 NCBI chr17:47,662,553...47,696,453
Ensembl chr17:47,662,532...47,696,444
JBrowse link
endoplasmic reticulum-endosome membrane contact site term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mospd2 motile sperm domain containing 2 ISO (PMID:29858488) RGD PMID:29858488 NCBI chr  X:31,140,967...31,182,823
Ensembl chr  X:31,140,960...31,182,816
JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 ISO (PMID:24105263) RGD PMID:24105263 NCBI chr10:86,313,430...86,335,868
Ensembl chr10:86,313,383...86,335,923
JBrowse link
G Stard3nl STARD3 N-terminal like ISO (PMID:24105263) RGD PMID:24105263 NCBI chr17:47,662,553...47,696,453
Ensembl chr17:47,662,532...47,696,444
JBrowse link
G Tmcc1 transmembrane and coiled-coil domain family 1 ISO (PMID:30220460) RGD PMID:30220460 NCBI chr 4:147,920,987...148,048,852
Ensembl chr 4:147,921,724...148,048,726
JBrowse link
endoplasmic reticulum-plasma membrane contact site term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2cd2l C2CD2-like ISO (PMID:28209843) RGD PMID:28209843 NCBI chr 8:48,641,792...48,652,119
Ensembl chr 8:48,641,801...48,652,071
JBrowse link
G Esyt2 extended synaptotagmin 2 ISO (PMID:27044890), (PMID:30220461) RGD PMID:27044890, PMID:30220461 NCBI chr 6:144,156,021...144,248,374
Ensembl chr 6:144,156,175...144,245,545
JBrowse link
G Esyt3 extended synaptotagmin 3 ISO (PMID:30220461) RGD PMID:30220461 NCBI chr 8:107,555,417...107,602,414
Ensembl chr 8:107,555,277...107,602,263
JBrowse link
G Gramd1a GRAM domain containing 1A ISS
ISO
IEA
GO_REF:0000024
(MGI:6242147|PMID:30220461)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30220461 GO_REF:0000024, GO_REF:0000107, MGI:6242147 NCBI chr 1:89,563,982...89,590,406
Ensembl chr 1:89,563,976...89,590,490
JBrowse link
G Gramd1b GRAM domain containing 1B ISO (PMID:30220461)
(MGI:6242147|PMID:30220461)
RGD PMID:30220461 MGI:6242147 NCBI chr 8:44,160,634...44,399,110
Ensembl chr 8:44,165,367...44,327,551
JBrowse link
G Gramd1c GRAM domain containing 1C ISO (MGI:6242147|PMID:30220461) RGD PMID:30220461 MGI:6242147 NCBI chr11:61,609,370...61,659,355
NCBI chr11:62,580,983...62,634,961
Ensembl chr11:61,605,937...62,634,803
JBrowse link
G Osbpl5 oxysterol binding protein-like 5 ISO (PMID:26206935), (PMID:30220461) RGD PMID:26206935, PMID:30220461 NCBI chr 1:216,866,263...216,920,625
Ensembl chr 1:216,866,245...216,920,625
JBrowse link
G Sacm1l SAC1 like phosphatidylinositide phosphatase IDA
ISO
PMID:27044890
(PMID:27044890)
RGD PMID:27044890, PMID:27044890 RGD:25671387 NCBI chr 8:132,607,166...132,663,502
Ensembl chr 8:132,607,166...132,663,502
JBrowse link
G Saraf store-operated calcium entry-associated regulatory factor ISS
ISO
GO_REF:0000024
(PMID:22464749)
UniProt
RGD
PMID:22464749 GO_REF:0000024 NCBI chr16:61,735,189...61,753,438
Ensembl chr16:61,735,181...61,753,476
JBrowse link
G Stimate STIM activating enhancer ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr16:6,903,212...6,958,786
Ensembl chr16:6,903,212...6,958,783
JBrowse link
mitochondria-associated endoplasmic reticulum membrane term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 ISO (PMID:23455425) RGD PMID:23455425 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 ISO
ISS
(PMID:27995898)
GO_REF:0000024
RGD
UniProt
PMID:27995898 GO_REF:0000024 NCBI chr 2:210,438,884...210,474,350
Ensembl chr 2:210,438,893...210,473,761
JBrowse link
G Atg14 autophagy related 14 ISO
IBA
(MGI:5476569|PMID:23455425)
PMID:21873635
RGD PMID:23455425, PMID:21873635 MGI:5476569, RGD:13792537 NCBI chr15:24,343,418...24,374,776
Ensembl chr15:24,343,314...24,374,753
JBrowse link
G Atg5 autophagy related 5 IEA
ISO
GO_REF:0000107
(MGI:5476569|PMID:23455425)
Ensembl
RGD
PMID:23455425 GO_REF:0000107, MGI:5476569 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Bcap31 B-cell receptor-associated protein 31 ISO (PMID:31206022) RGD PMID:31206022 NCBI chr  X:157,094,365...157,126,397
Ensembl chr  X:157,095,937...157,126,393
JBrowse link
G Bcl2l10 BCL2 like 10 ISO
ISS
(PMID:27995898)
GO_REF:0000024
RGD
UniProt
PMID:27995898 GO_REF:0000024 NCBI chr 8:82,288,705...82,294,750
Ensembl chr 8:82,288,705...82,294,744
JBrowse link
G Canx calnexin ISO (PMID:23455425) RGD PMID:23455425 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Clcc1 chloride channel CLIC-like 1 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:31653868)
UniProt
Ensembl
RGD
PMID:31653868 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:211,450,426...211,479,885
Ensembl chr 2:211,450,484...211,479,884
JBrowse link
G Mboat7 membrane bound O-acyltransferase domain containing 7 ISO (PMID:23510452) RGD PMID:23510452 NCBI chr 1:64,100,159...64,114,437
Ensembl chr 1:64,101,018...64,113,792
JBrowse link
G Mboat7l1 membrane bound O-acyltransferase domain containing 7-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:64,031,859...64,046,137
Ensembl chr 1:64,031,859...64,046,135
JBrowse link
G Pdzd8 PDZ domain containing 8 ISO (PMID:29097544)
(MGI:6094720|PMID:29097544)
RGD PMID:29097544 MGI:6094720 NCBI chr 1:280,458,041...280,515,650
Ensembl chr 1:280,458,041...280,515,650
JBrowse link
G Rab32 RAB32, member RAS oncogene family ISO (PMID:25767741) RGD PMID:25767741 NCBI chr 1:4,638,663...4,653,220
Ensembl chr 1:4,637,491...4,653,210
JBrowse link
G Rab38 RAB38, member RAS oncogene family ISO (PMID:25767741) RGD PMID:25767741 NCBI chr 1:152,072,716...152,153,449
Ensembl chr 1:152,072,665...152,153,449
JBrowse link
G Serac1 serine active site containing 1 ISO (PMID:22683713) RGD PMID:22683713 NCBI chr 1:46,934,499...46,978,264
Ensembl chr 1:46,942,192...46,978,261
JBrowse link
G Stx17 syntaxin 17 ISO (PMID:23455425) RGD PMID:23455425 NCBI chr 5:63,866,346...63,926,276
Ensembl chr 5:63,870,432...63,922,730
JBrowse link
G Tmem41b transmembrane protein 41B ISO
ISS
(PMID:30352685)
(MGI:6280160|PMID:30352685)
GO_REF:0000024
RGD
UniProt
PMID:30352685 GO_REF:0000024, MGI:6280160 NCBI chr 1:174,605,833...174,620,192
Ensembl chr 1:174,605,834...174,620,064
JBrowse link
G Tmx2 thioredoxin-related transmembrane protein 2 ISO (PMID:31735293) RGD PMID:31735293 NCBI chr 3:72,073,429...72,081,079
Ensembl chr 3:72,073,431...72,081,079
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 ISO (PMID:23455425) RGD PMID:23455425 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 ISO (PMID:31206022) RGD PMID:31206022 NCBI chr 1:80,617,749...80,630,253
Ensembl chr 1:80,618,154...80,630,038
JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 ISO (PMID:23455425) RGD PMID:23455425 NCBI chr 6:107,031,411...107,080,590
Ensembl chr 6:107,031,412...107,080,524
JBrowse link
mitochondrial crista junction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Micos13 mitochondrial contact site and cristae organizing system subunit 13 ISO (PMID:25997101) RGD PMID:25997101 NCBI chr 9:10,446,567...10,449,566
Ensembl chr 9:10,446,699...10,449,566
JBrowse link
mitochondrial inner-outer membrane contact site term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckmt1 creatine kinase, mitochondrial 1 IDA RGD PMID:1998693 RGD:11565110 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
nucleus-vacuole junction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3r4 phosphoinositide-3-kinase, regulatory subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,300,248...114,350,686
Ensembl chr 8:114,300,257...114,350,681
JBrowse link

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.