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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of molecular function
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Accession:GO:0044092 term browser browse the term
Definition:Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.


show annotations for term's descendants           Sort by:
cytoplasmic sequestering of NF-kappaB term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkbia NFKB inhibitor alpha IMP RGD PMID:9918814 PMID:16580131 PMID:9343439 PMID:10620707 RGD:2298880, RGD:2298917, RGD:2298908, RGD:2298882 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta IMP RGD PMID:9343439 PMID:16580131 RGD:2298908, RGD:2298917 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
cytoplasmic sequestering of transcription factor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Keap1 Kelch-like ECH-associated protein 1 IMP RGD PMID:11439354 RGD:727319 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 IMP RGD PMID:20705669 RGD:5509896 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap5 A-kinase anchoring protein 5 IDA RGD PMID:20410303 RGD:7242424 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578 		JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP RGD PMID:19574217 RGD:6902943 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738 		JBrowse link
G Akap9 A-kinase anchoring protein 9 IMP RGD PMID:18772391 RGD:2313147 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 IMP RGD PMID:15147298 RGD:2315493 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Npr3 natriuretic peptide receptor 3 IDA RGD PMID:8702617 RGD:1601497 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955 		JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor IDA RGD PMID:12193573 RGD:625678 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
negative regulation of AMPA receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grip1 glutamate receptor interacting protein 1 IMP RGD PMID:12597860 RGD:152995391 NCBI chr 7:54,934,856...55,592,274
Ensembl chr 7:54,934,250...55,592,273 		JBrowse link
negative regulation of anion channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk6 G protein-coupled receptor kinase 6 IMP Cl-/HCO3- exchange activity RGD PMID:17170521 RGD:5684927 NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644 		JBrowse link
negative regulation of ATP-dependent activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnn3 calponin 3 IDA microtubule-activated ncd 335 ATPase RGD PMID:12564930 RGD:727577 NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104 		JBrowse link
negative regulation of calcium ion transmembrane transporter activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:15728831 RGD:8554004 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
negative regulation of calcium-dependent ATPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IMP RGD PMID:10861851 RGD:9590176 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
negative regulation of catalytic activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl4 angiopoietin-like 4 TAS RGD PMID:15863837 RGD:1578348 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Cast calpastatin IDA RGD PMID:17429681 RGD:1626249 NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659 		JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R IMP arylalkylamine N-acetyltransferase activity RGD PMID:15798208 RGD:9854643 NCBI chr 5:148,542,999...148,574,888
Ensembl chr 5:148,543,044...148,574,867 		JBrowse link
G Renbp renin binding protein IDA RGD PMID:11726282 RGD:5132613 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516 		JBrowse link
negative regulation of cation channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IDA RGD PMID:20624795 RGD:6849299 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Fgf12 fibroblast growth factor 12 IDA RGD PMID:12401812 RGD:6484231 NCBI chr11:71,997,151...72,564,757
Ensembl chr11:71,997,099...72,562,607 		JBrowse link
negative regulation of CREB transcription factor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 IDA RGD PMID:15829559 RGD:1599733 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein IDA RGD PMID:12810716 RGD:632260 NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IDA RGD PMID:22975349 RGD:8554232 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Rgn regucalcin IDA RGD PMID:1656206 RGD:9590243 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 IDA RGD PMID:10721722 RGD:632478 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 IDA RGD PMID:10721722 RGD:632478 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IMP RGD PMID:22584582 RGD:10045364 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:23690069 RGD:13792722 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Htt huntingtin IMP RGD PMID:17124493 RGD:6902918 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IDA RGD PMID:15211592 RGD:1625666 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IMP caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Arrb2 arrestin, beta 2 IMP RGD PMID:19171933 RGD:5510006 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Ep300 E1A binding protein p300 IMP cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Gpi glucose-6-phosphate isomerase IMP RGD PMID:12615053 RGD:1600634 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 IMP RGD PMID:15102845 RGD:1304324 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hnf1a HNF1 homeobox A IMP RGD PMID:21874357 RGD:150540304 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B IDA reduced cleavage of Casp8 and Casp9 in brain following hypoxic/ischemic injury RGD PMID:16397188 RGD:1626654 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Il6 interleukin 6 IDA RGD PMID:19061939 RGD:2306937 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mdm2 MDM2 proto-oncogene IMP caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Por cytochrome p450 oxidoreductase IMP caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ptma prothymosin alpha IDA RGD PMID:12522243 RGD:734494 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333 		JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 IDA
IMP		 RGD PMID:8183366 PMID:8799886 RGD:61642, RGD:9743956 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534 		JBrowse link
G Mtnr1b melatonin receptor 1B IDA RGD PMID:14962062 RGD:9588668 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737 		JBrowse link
negative regulation of DNA binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac2 histone deacetylase 2 IMP RGD PMID:21383775 RGD:9590238 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 IMP Rela RGD PMID:17473852 RGD:5688754 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Id1 inhibitor of DNA binding 1 IMP RGD PMID:7623812 RGD:9686118 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Sirt1 sirtuin 1 IMP Rela RGD PMID:22044919 RGD:10047123 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
negative regulation of DNA-binding transcription factor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egln1 egl-9 family hypoxia-inducible factor 1 IDA RGD PMID:20308610 RGD:6483365 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha IDA STAT5b RGD PMID:16584384 RGD:1625011 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hr HR, lysine demethylase and nuclear receptor corepressor IDA RGD PMID:11641275 RGD:1599577 NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313 		JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 IMP RGD PMID:12697699 RGD:1624302 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011 		JBrowse link
G Rpl11 ribosomal protein L11 IDA RGD PMID:16280383 RGD:11035228 NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599 		JBrowse link
G Thra thyroid hormone receptor alpha IDA RGD PMID:2537467 RGD:1580107 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thra_v2 thyroid hormone receptor alpha, variant 2 IDA RGD PMID:2537467 RGD:1580107
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IDA RGD PMID:19240864 RGD:7411612 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Renbp renin binding protein IDA RGD PMID:11926999 RGD:727355 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516 		JBrowse link
G Serpine1 serpin family E member 1 IDA RGD PMID:10717410 RGD:8547889 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
negative regulation of GTP binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rap1gap Rap1 GTPase-activating protein IMP RGD PMID:19066305 RGD:9835342 NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253 		JBrowse link
negative regulation of GTP cyclohydrolase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gchfr GTP cyclohydrolase I feedback regulator IDA RGD PMID:8702680 RGD:728623 NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080 		JBrowse link
negative regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:15870074 RGD:2325307 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Arrb1 arrestin, beta 1 IDA RGD PMID:1517224 RGD:631708 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 IDA RGD PMID:1517224 RGD:631708 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 IDA RGD PMID:17662049 RGD:7240703 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Ptprn2 protein tyrosine phosphatase, receptor type N2 IDA RGD PMID:16413169 RGD:1625628 NCBI chr 6:137,439,572...138,191,575
Ensembl chr 6:137,439,540...138,191,575 		JBrowse link
G Rgn regucalcin IMP RGD PMID:11510494 RGD:9590205 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Tsc1 TSC complex subunit 1 IMP RGD PMID:15611338 RGD:1601406 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
negative regulation of guanyl-nucleotide exchange factor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha IDA RGD PMID:9582312 RGD:1581075 NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta IDA RGD PMID:9582312 RGD:1581075 NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha IDA RGD PMID:9582312 RGD:1581075 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin IDA RGD PMID:15336960 RGD:9686438 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
negative regulation of hexokinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gckr glucokinase regulator IDA RGD PMID:14627435 RGD:1598592 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
negative regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcz protein kinase C, zeta IDA inhibition of acid sphingomyelinase translocation to cell surface and activation RGD PMID:17346242 RGD:1642658 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snx27 sorting nexin 27 IDA RGD PMID:21422294 RGD:8554349 NCBI chr 2:182,135,904...182,218,906
Ensembl chr 2:182,135,905...182,218,906 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP RGD PMID:12064607 RGD:1299562 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884 		JBrowse link
negative regulation of kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csk C-terminal Src kinase IDA RGD PMID:10411542 RGD:5134371 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 IMP RGD PMID:19762078 RGD:150429972 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 IDA RGD PMID:9366267 RGD:5134981 NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 IDA due to an autoinhibitory domain RGD PMID:15081430 RGD:2298791 NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905 		JBrowse link
negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IDA RGD PMID:2280766 RGD:9590217 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
negative regulation of lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 IDA RGD PMID:10419291 RGD:1626385 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Por cytochrome p450 oxidoreductase IDA phospholipase D RGD PMID:18801337 RGD:4889814 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
negative regulation of lipoprotein lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angptl4 angiopoietin-like 4 TAS RGD PMID:14570927 RGD:1302799 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:17182785 RGD:2301767 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:12933696 RGD:1626126 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Kng2 kininogen 2 IDA in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IDA RGD PMID:9857190 RGD:10044039 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:14612383 RGD:1580517 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mprip myosin phosphatase Rho interacting protein IMP RGD PMID:17661354 RGD:9685557 NCBI chr10:44,453,949...44,573,843
Ensembl chr10:44,453,929...44,569,118 		JBrowse link
negative regulation of NAD(P)H oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 IMP RGD PMID:19752235 RGD:8549634 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
negative regulation of nitric-oxide synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 IMP RGD PMID:16537391 RGD:1582129 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378 		JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:18561998 RGD:2316219 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 IMP RGD PMID:18561998 RGD:2316219 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:18005341 RGD:10045554 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase IMP RGD PMID:20698836 RGD:13463453 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
negative regulation of P-type sodium:potassium-exchanging transporter activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxyd2 FXYD domain-containing ion transport regulator 2 IMP RGD PMID:15280368 RGD:1598989 NCBI chr 8:45,712,901...45,720,032
Ensembl chr 8:45,712,903...45,720,203 		JBrowse link
negative regulation of peptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyss cystatin S IDA Papain
Ficin		 RGD PMID:7575236 PMID:3263967 RGD:2306757, RGD:1299643 NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610 		JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpin1 lipin 1 IMP RGD PMID:21715287 RGD:38599010 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
negative regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 IDA RGD PMID:2969352 RGD:7421659 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
negative regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snap91 synaptosome associated protein 91 IDA RGD PMID:11779129 RGD:70605 NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367 		JBrowse link
negative regulation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snap91 synaptosome associated protein 91 IDA RGD PMID:9188501 RGD:13506241 NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367 		JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppia peptidylprolyl isomerase A IDA RGD PMID:19832699 RGD:7247324 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B IDA
IMP		 RGD PMID:12016225 PMID:10585469 RGD:625568, RGD:9999389 NCBI chr10:79,938,055...79,954,085
Ensembl chr10:79,938,066...79,954,083 		JBrowse link
G Rgn regucalcin IMP RGD PMID:10922512 RGD:9590172 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
negative regulation of potassium ion transmembrane transporter activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pten phosphatase and tensin homolog IMP RGD PMID:24103758 RGD:12802338 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
negative regulation of protein binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adnp activity-dependent neuroprotector homeobox IDA beta-amyloid aggregation RGD PMID:14706557 RGD:2312790 NCBI chr 3:156,886,921...156,921,500
Ensembl chr 3:156,891,381...156,917,312 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IMP RGD PMID:9553145 RGD:2303817 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Id1 inhibitor of DNA binding 1 IMP RGD PMID:23831032 RGD:9686139 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IMP RGD PMID:24636259 RGD:12789709 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Plk2 polo-like kinase 2 IMP RGD PMID:20802490 RGD:152995511 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha IMP RGD PMID:22198280 RGD:5687133 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 IDA RGD PMID:12270929 RGD:1299366 NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463 		JBrowse link
G Senp2 SUMO specific peptidase 2 IDA Axin1 to Dvl1 RGD PMID:10944533 RGD:1299408 NCBI chr11:78,981,429...79,018,274
Ensembl chr11:78,981,432...79,018,238 		JBrowse link
negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IDA in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Daxx death-domain associated protein IMP RGD PMID:17289031 RGD:9587773 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Drd1 dopamine receptor D1 IMP RGD PMID:12688394 RGD:1581394 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd5 dopamine receptor D5 IMP RGD PMID:12688394 RGD:1581394 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 IMP RGD PMID:21668448 RGD:10401931 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Il6 interleukin 6 IDA Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ilk integrin-linked kinase IMP GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Pcp4 Purkinje cell protein 4 IDA RGD PMID:10751438 RGD:1579763 NCBI chr11:35,759,711...35,861,725
Ensembl chr11:35,800,713...35,861,725 		JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha TAS RGD PMID:1491692 RGD:729428 NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282 		JBrowse link
G Rgn regucalcin IMP RGD PMID:11455566 RGD:9590207 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:11500506 RGD:13508599 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
negative regulation of receptor binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gper1 G protein-coupled estrogen receptor 1 IMP angiotensin receptor RGD PMID:24262995 RGD:39939015 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
negative regulation of selenocysteine insertion sequence binding term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif4a3 eukaryotic translation initiation factor 4A3 IDA RGD PMID:19716792 RGD:10045552 NCBI chr10:104,549,038...104,559,032
Ensembl chr10:104,549,038...104,559,057 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpina1 serpin family A member 1 IDA RGD PMID:19240864 RGD:7411612 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 IDA RGD PMID:12771515 RGD:724699 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
negative regulation of signaling receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a PPARG coactivator 1 alpha IMP extrasynaptic NMDAR RGD PMID:22593067 RGD:6484258 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Pten phosphatase and tensin homolog IMP GABA A receptors RGD PMID:24044036 RGD:12802358 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
negative regulation of sodium:proton antiporter activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd3 dopamine receptor D3 IMP RGD PMID:15265811 RGD:1625070 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma IMP RGD PMID:16556873 RGD:1580657 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
negative regulation of transporter activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IMP P-glycoprotein RGD PMID:19049803 RGD:2307019 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 IDA RGD PMID:17960496 RGD:7207144 NCBI chr12:41,385,234...41,448,930
Ensembl chr12:41,378,897...41,448,927 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IDA RGD PMID:15024042 RGD:13514097 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074 		JBrowse link
G Cbarp CACN subunit beta associated regulatory protein IMP RGD PMID:24751537 RGD:10047103 NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:9,566,364...9,575,204 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 IMP RGD PMID:26584289 RGD:155804278 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:15937148 RGD:9835002 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 IDA RGD PMID:14679187 PMID:21943416 PMID:21943417 RGD:7243967, RGD:7242916, RGD:12910700 NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 IDA RGD PMID:19219384 PMID:21943416 PMID:14679187 RGD:7243947, RGD:7242916, RGD:7243967 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043 		JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 IDA RGD PMID:14679187 RGD:7243967 NCBI chr 1:154,523,903...154,530,865
Ensembl chr 1:154,523,830...154,532,020 		JBrowse link
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