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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of digestive system process
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Accession:GO:0044058 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.


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regulation of digestive system process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:12690433 RGD:2304324 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Oxtr oxytocin receptor IMP RGD PMID:12690433 RGD:2304324 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
negative regulation of gastric acid secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr39 G protein-coupled receptor 39 ISO MGI:MGI:3723512 (MGI:MGI:3722947|PMID:17030183) RGD PMID:17030183 MGI:MGI:3722947 NCBI chr13:42,008,642...42,220,737
Ensembl chr13:42,008,842...42,009,738
JBrowse link
G Nmu neuromedin U IDA PMID:12584108 UniProt PMID:12584108 RGD:1642125 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:11764003 RGD:2304192 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Oxtr oxytocin receptor IMP RGD PMID:11764003 RGD:2304192 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:15961884, PMID:21873635 RGD:10043339, RGD:13792537 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Tff2 trefoil factor 2 ISO
IBA
MGI:MGI:2179101 (MGI:MGI:2158108|PMID:11805131)
PMID:21873635
RGD PMID:11805131, PMID:21873635 MGI:MGI:2158108, RGD:13792537 NCBI chr20:9,872,669...9,876,008
Ensembl chr20:9,872,680...9,876,008
JBrowse link
G Ucn urocortin IDA RGD PMID:21540451 RGD:5490560 NCBI chr 6:26,602,144...26,602,974
Ensembl chr 6:26,602,144...26,602,974
JBrowse link
negative regulation of gastric emptying term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nmu neuromedin U IDA PMID:12584108 UniProt PMID:12584108 RGD:1642125 NCBI chr14:34,353,683...34,381,968
Ensembl chr14:34,354,503...34,381,828
JBrowse link
G Ptger1 prostaglandin E receptor 1 IMP RGD PMID:10807413 RGD:10043357 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
negative regulation of gastrin-induced gastric acid secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15961884 RGD:10043339 NCBI chr 2:263,895,093...263,979,682
Ensembl chr 2:263,895,241...263,979,698
JBrowse link
G Sct secretin IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:11123201, PMID:21873635 RGD:9590235, RGD:13792537 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
negative regulation of intestinal absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 IMP RGD PMID:23333829 RGD:11099975 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Hamp hepcidin antimicrobial peptide ISO (PMID:12469120) RGD PMID:12469120 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Isx intestine-specific homeobox ISO MGI:MGI:3703167 (MGI:MGI:5638293|PMID:25701869) RGD PMID:25701869 MGI:MGI:5638293 NCBI chr19:14,198,899...14,219,269
Ensembl chr19:14,198,899...14,218,531
JBrowse link
negative regulation of intestinal cholesterol absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg5 ATP binding cassette subfamily G member 5 ISO (PMID:11099417) RGD PMID:11099417 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 ISO (PMID:11099417) RGD PMID:11099417 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
negative regulation of intestinal phytosterol absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg5 ATP binding cassette subfamily G member 5 ISO (PMID:11099417) RGD PMID:11099417 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 ISO (PMID:11099417) RGD PMID:11099417 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
negative regulation of pancreatic amylase secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Madd MAP-kinase activating death domain IMP RGD PMID:23702376 RGD:9588639 NCBI chr 3:79,960,301...80,003,023
Ensembl chr 3:79,960,301...80,003,032
JBrowse link
negative regulation of pancreatic juice secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 ISO
IEA
(MGI:MGI:3822255|PMID:18806227)
GO_REF:0000107
RGD
Ensembl
PMID:18806227 GO_REF:0000107, MGI:MGI:3822255 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Stk39 serine threonine kinase 39 ISO (MGI:MGI:5002793|PMID:21317537) RGD PMID:21317537 MGI:MGI:5002793 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO (MGI:MGI:5002793|PMID:21317537) RGD PMID:21317537 MGI:MGI:5002793 NCBI chr 4:152,452,211...152,578,469
Ensembl chr 4:152,452,848...152,578,446
JBrowse link
G Wnk3 WNK lysine deficient protein kinase 3 ISO (MGI:MGI:5002793|PMID:21317537) RGD PMID:21317537 MGI:MGI:5002793 NCBI chr  X:20,316,081...20,459,245
Ensembl chr  X:20,316,893...20,454,357
JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 ISO (MGI:MGI:5002793|PMID:21317537) RGD PMID:21317537 MGI:MGI:5002793 NCBI chr10:89,181,139...89,198,213
Ensembl chr10:89,181,165...89,198,213
JBrowse link
negative regulation of saliva secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurog1 neurogenin 1 ISO UniProtKB:Q6ZNK6|UniProtKB:Q8TF63 (PMID:23419067) RGD PMID:23419067 NCBI chr17:9,154,656...9,156,175
Ensembl chr17:9,154,656...9,156,175
JBrowse link
G Tifab TIFA inhibitor ISO UniProtKB:Q8TF63|UniProtKB:Q92886 (PMID:23419067) RGD PMID:23419067 NCBI chr17:9,234,948...9,239,266
Ensembl chr17:9,236,249...9,239,265
JBrowse link
positive regulation of digestive system process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone IDA gut paracellular permeability RGD PMID:17234701 RGD:5491013 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
positive regulation of gastric acid secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IMP RGD PMID:11313306 RGD:1581605 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:12007927 RGD:9835018 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 IMP RGD PMID:15781048 RGD:2317117 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
positive regulation of hindgut contraction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:19258489 RGD:2304084 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Pawr pro-apoptotic WT1 regulator IDA RGD PMID:14724155 RGD:9835340 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
positive regulation of intestinal cholesterol absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO (MGI:MGI:5302163|PMID:22045928) RGD PMID:22045928 MGI:MGI:5302163 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 ISS
ISO
GO_REF:0000024
(MGI:MGI:5574251|PMID:24650549)
UniProt
RGD
PMID:24650549 GO_REF:0000024, MGI:MGI:5574251 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:5780634|PMID:26833026)
UniProt
RGD
PMID:26833026 GO_REF:0000024, MGI:MGI:5780634 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
JBrowse link
positive regulation of intestinal epithelial structure maintenance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a5 solute carrier family 22 member 5 ISO
IEA
(PMID:18005709)
GO_REF:0000107
RGD
Ensembl
PMID:18005709 GO_REF:0000107 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
positive regulation of pancreatic amylase secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vamp8 vesicle-associated membrane protein 8 ISO MGI:MGI:3056083 (MGI:MGI:3801544|PMID:18535671) RGD PMID:18535671 MGI:MGI:3801544 NCBI chr 4:100,250,301...100,252,756
Ensembl chr 4:100,250,301...100,252,755
JBrowse link
positive regulation of pancreatic juice secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 ISO (MGI:MGI:3822255|PMID:18806227) RGD PMID:18806227 MGI:MGI:3822255 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Sct secretin IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:11123201, PMID:21873635 RGD:9590235, RGD:13792537 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 IDA RGD PMID:2755938 RGD:10044250 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
positive regulation of pancreatic trypsinogen secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp13 matrix metallopeptidase 13 IDA RGD PMID:12771515 RGD:724699 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
positive regulation of saliva secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18275933 RGD:5129135 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Aqp1 aquaporin 1 ISS
ISO
GO_REF:0000024
(PMID:15727941), (PMID:9096382)
UniProt
RGD
PMID:9096382, PMID:15727941 GO_REF:0000024 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:11448478 RGD:5147474 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tac4 tachykinin precursor 4 ISO (MGI:MGI:1926622|PMID:11062498) RGD PMID:11062498 MGI:MGI:1926622 NCBI chr10:83,081,168...83,089,487
Ensembl chr10:83,081,168...83,089,481
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:11448478 RGD:5147474 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
positive regulation of small intestinal transit term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghrl ghrelin and obestatin prepropeptide IDA RGD PMID:21874246 RGD:12910732 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:21874246, PMID:15890336 RGD:12910732, RGD:12907565 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
regulation of gastric acid secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hip1r huntingtin interacting protein 1 related ISO (MGI:MGI:3801545|PMID:18535670) RGD PMID:18535670 MGI:MGI:3801545 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:3611738|PMID:16314573), (MGI:MGI:5292649|PMID:19491250)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:16314573, PMID:19491250 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3611738, MGI:MGI:5292649 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
regulation of gastric motility term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghrl ghrelin and obestatin prepropeptide IDA RGD PMID:23525979 RGD:12907567 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:23525979 RGD:12907567 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Tymp thymidine phosphorylase ISO (PMID:9924029) RGD PMID:9924029 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
regulation of hindgut contraction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:16873401 RGD:1625276 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
regulation of intestinal absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A IMP RGD PMID:22049154 RGD:8657330 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Epb41 erythrocyte membrane protein band 4.1 ISO (MGI:MGI:5496297|PMID:23460639) RGD PMID:23460639 MGI:MGI:5496297 NCBI chr 5:150,081,727...150,243,186
Ensembl chr 5:150,084,611...150,167,077
JBrowse link
regulation of intestinal cholesterol absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 ISO
IBA
(MGI:MGI:1339009|PMID:10073953)
PMID:21873635
RGD PMID:10073953, PMID:21873635 MGI:MGI:1339009, RGD:13792537 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 ISO MGI:MGI:2157148 (MGI:MGI:84652|PMID:8962133) RGD PMID:8962133 MGI:MGI:84652 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 ISO
IBA
MGI:MGI:2157162 (MGI:MGI:1096980|PMID:9323588)
PMID:21873635
RGD PMID:9323588, PMID:21873635 MGI:MGI:1096980, RGD:13792537 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Apoa5 apolipoprotein A5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Lep leptin ISO (MGI:MGI:2386518|PMID:12114517) RGD PMID:12114517 MGI:MGI:2386518 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
regulation of intestinal epithelial structure maintenance term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 ISO
ISS
(MGI:MGI:5009210|PMID:9512516)
GO_REF:0000024
RGD
UniProt
PMID:9512516 GO_REF:0000024, MGI:MGI:5009210 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
regulation of intestinal lipid absorption term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgat1 diacylglycerol O-acyltransferase 1 IMP RGD PMID:18768481 RGD:10400848 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 ISS
ISO
GO_REF:0000024
(MGI:MGI:4947032|PMID:21177474)
UniProt
RGD
PMID:21177474 GO_REF:0000024, MGI:MGI:4947032 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
regulation of saliva secretion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 ISO (PMID:19102732) RGD PMID:19102732 NCBI chr 2:51,673,480...51,747,533
Ensembl chr 2:51,672,722...51,750,369
JBrowse link
G Oprk1 opioid receptor, kappa 1 ISO
ISS
(MGI:MGI:1197118|PMID:9463367)
GO_REF:0000024
RGD
UniProt
PMID:9463367 GO_REF:0000024, MGI:MGI:1197118 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    multicellular organismal process 9055
      system process 3445
        digestive system process 116
          regulation of digestive system process 55
            modulation by symbiont of host digestive system process 0
            negative regulation of digestive system process + 22
            positive regulation of digestive system process + 22
            regulation of gastric acid secretion + 12
            regulation of gastric motility + 5
            regulation of hindgut contraction + 3
            regulation of intestinal absorption + 16
            regulation of intestinal epithelial structure maintenance + 2
            regulation of pancreatic juice secretion + 11
            regulation of saliva secretion + 9
            regulation of small intestinal transit + 2
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of multicellular organismal process 3453
          regulation of system process 654
            regulation of digestive system process 55
              modulation by symbiont of host digestive system process 0
              negative regulation of digestive system process + 22
              positive regulation of digestive system process + 22
              regulation of gastric acid secretion + 12
              regulation of gastric motility + 5
              regulation of hindgut contraction + 3
              regulation of intestinal absorption + 16
              regulation of intestinal epithelial structure maintenance + 2
              regulation of pancreatic juice secretion + 11
              regulation of saliva secretion + 9
              regulation of small intestinal transit + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.