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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of gene expression via chromosomal CpG island methylation
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Accession:GO:0044027 term browser browse the term
Definition:An epigenetic gene regulation mechanism that negatively regulates gene expression by methylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide associated with the transcription start site of genes.
Synonyms:exact_synonym: DNA hypermethylation of CpG island;   epigenetic regulation of gene expression via CpG island hypermethylation;   hypermethylation of CpG island;   negative regulation of gene expression via CpG island hypermethylation;   negative regulation of gene expression via chromosomal CpG dinucleotide methylation;   negative regulation of gene expression via chromosomal DNA cytosine methylation
 broad_synonym: maintenance of DNA methylation
 related_synonym: DNA hypermethylation of CG island;   negative regulation of gene expression via CpG island methylation;   negative regulation of gene expression via chromosomal CG dinucleotide methylation

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negative regulation of gene expression via chromosomal CpG island methylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1 DNA repair associated acts_upstream_of_positive_effect ISO (PMID:20820192)
(MGI:5009779|PMID:20820192)		 BHF-UCL PMID:20820192 MGI:5009779 NCBI chrNW_004955451:16,819,463...16,870,780
Ensembl chrNW_004955451:16,819,023...16,855,528 		JBrowse link
G Ctcf CCCTC-binding factor acts_upstream_of_or_within ISO (PMID:14716017) MGI PMID:14716017 NCBI chrNW_004955484:9,041,226...9,092,924
Ensembl chrNW_004955484:9,042,524...9,064,927 		JBrowse link
G Dnmt1 DNA methyltransferase 1 involved_in ISO (MGI:3852629|PMID:17576694)
(PMID:24623306)
(PMID:18754681), (PMID:21745816)		 RGD
UniProt		 PMID:12473678 PMID:17576694 PMID:18754681 PMID:21745816 PMID:24623306 MGI:3852629 RGD:1359078 NCBI chrNW_004955495:1,465,529...1,505,379
Ensembl chrNW_004955495:1,465,480...1,505,462 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha involved_in ISO (MGI:5009774|PMID:21047779)
(PMID:12138111), (PMID:19786833), (PMID:23042785)		 BHF-UCL
UniProt		 PMID:12138111 PMID:19786833 PMID:21047779 PMID:23042785 MGI:5009774 NCBI chrNW_004955469:7,264,431...7,367,059
Ensembl chrNW_004955469:7,269,952...7,367,059 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 acts_upstream_of_or_within ISO (PMID:17212651) MGI PMID:17212651 NCBI chrNW_004955437:396,736...411,144
Ensembl chrNW_004955437:396,742...411,144 		JBrowse link
G Hells helicase, lymphoid specific involved_in ISO (MGI:3620346|PMID:15105378) UniProt PMID:15105378 MGI:3620346 NCBI chrNW_004955507:995,389...1,034,852
Ensembl chrNW_004955507:990,429...1,034,852 		JBrowse link
G Mecp2 methyl-CpG binding protein 2 involved_in ISO (PMID:23960241) BHF-UCL PMID:23960241 NCBI chrNW_004955580:674,014...737,586
Ensembl chrNW_004955580:679,109...735,288 		JBrowse link
G Mphosph8 M-phase phosphoprotein 8 involved_in ISO (PMID:20871592) UniProt PMID:20871592 NCBI chrNW_004955497:518,462...546,748 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor acts_upstream_of_positive_effect ISO (PMID:19786833) BHF-UCL PMID:19786833 NCBI chrNW_004955461:2,714,022...2,718,872
Ensembl chrNW_004955461:2,714,022...2,718,982 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 ISO RGD PMID:22041901 RGD:9491827 NCBI chrNW_004955409:37,369,507...37,378,034
Ensembl chrNW_004955409:37,369,234...37,378,093 		JBrowse link
G Uhrf1 ubiquitin like with PHD and ring finger domains 1 involved_in ISO (PMID:17673620)
(MGI:3768689|PMID:17994007), (MGI:5442505|PMID:17673620)		 UniProt PMID:17673620 PMID:17994007 MGI:3768689 MGI:5442505 NCBI chrNW_004955495:4,153,898...4,154,611 JBrowse link
G Usp7 ubiquitin specific peptidase 7 involved_in ISO (PMID:21745816) UniProt PMID:21745816 NCBI chrNW_004955442:9,316,022...9,355,751
Ensembl chrNW_004955442:9,315,225...9,356,393 		JBrowse link
G Wt1 WT1 transcription factor acts_upstream_of_positive_effect ISO (PMID:23042785) ARUK-UCL PMID:23042785 NCBI chrNW_004955476:10,464,688...10,504,473
Ensembl chrNW_004955476:10,464,616...10,504,473 		JBrowse link
G Zfp57 ZFP57 zinc finger protein involved_in ISO (MGI:6284037|PMID:30602440) UniProt PMID:30602440 MGI:6284037 NCBI chrNW_004955583:151,338...154,827 JBrowse link
G Znf445 zinc finger protein 445 involved_in ISO (PMID:30602440)
(MGI:6284037|PMID:30602440)		 UniProt PMID:30602440 MGI:6284037 NCBI chrNW_004955420:26,972,008...26,995,063
Ensembl chrNW_004955420:26,986,101...26,991,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    metabolic process 7467
      negative regulation of metabolic process 2396
        negative regulation of macromolecule metabolic process 2178
          negative regulation of macromolecule biosynthetic process 1837
            negative regulation of gene expression 965
              negative regulation of gene expression, epigenetic 120
                negative regulation of gene expression via chromosomal CpG island methylation 15
Path 2
Term Annotations click to browse term
  biological_process 12346
    biological regulation 8880
      regulation of biological process 8618
        regulation of metabolic process 4808
          regulation of biosynthetic process 3812
            regulation of cellular biosynthetic process 3728
              regulation of macromolecule biosynthetic process 3635
                regulation of gene expression 3524
                  negative regulation of gene expression 965
                    negative regulation of gene expression, epigenetic 120
                      negative regulation of gene expression via chromosomal CpG island methylation 15
paths to the root