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ONTOLOGY REPORT - ANNOTATIONS


Term:cell dedifferentiation
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Accession:GO:0043697 term browser browse the term
Definition:The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment:Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.


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cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin dependent kinase 6 involved_in IEA InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936803:1,025,047...1,229,396
Ensembl chrNW_004936803:1,024,779...1,227,516
JBrowse link
G Esrrb estrogen related receptor beta involved_in ISO (MGI:5882870|PMID:23040477) UniProt PMID:23040477 MGI:5882870 NCBI chrNW_004936488:5,350,133...5,452,366
Ensembl chrNW_004936488:5,292,466...5,454,689
JBrowse link
G Fezf1 FEZ family zinc finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936605:3,027,138...3,030,442
Ensembl chrNW_004936605:3,027,122...3,030,449
JBrowse link
G Fezf2 FEZ family zinc finger 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936637:4,045,224...4,051,058
Ensembl chrNW_004936637:4,047,119...4,052,741
JBrowse link
G Nanog Nanog homeobox involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936892:181,834...187,691 JBrowse link
G Ncoa3 nuclear receptor coactivator 3 involved_in ISO (MGI:5440110|PMID:23019124) UniProt PMID:23019124 MGI:5440110 NCBI chrNW_004936514:5,900,135...5,967,862
Ensembl chrNW_004936514:5,901,601...5,967,865
JBrowse link
hepatocyte dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpd heterogeneous nuclear ribonucleoprotein D ISO RGD PMID:20102719 RGD:10042969 NCBI chrNW_004936738:2,096,370...2,115,135
Ensembl chrNW_004936738:2,096,370...2,113,604
JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfb platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573
JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in ISO PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chrNW_004936659:324,996...385,646
Ensembl chrNW_004936659:325,436...372,225
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15892
    developmental process 6292
      dedifferentiation 9
        cell dedifferentiation 9
          cell dedifferentiation involved in phenotypic switching + 2
          hepatocyte dedifferentiation 1
          kidney cortex tubule cell dedifferentiation 0
paths to the root