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ONTOLOGY REPORT - ANNOTATIONS


Term:cell dedifferentiation
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Accession:GO:0043697 term browser browse the term
Definition:The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment:Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.



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cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK6 cyclin dependent kinase 6 involved_in IEA InterPro
Ensembl
GO_REF:0000002 GO_REF:0000107 NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129
JBrowse link
G ESRRB estrogen related receptor beta involved_in ISO (MGI:5882870|PMID:23040477) UniProt PMID:23040477 MGI:5882870 NCBI chr 7:99,511,135...99,699,478
Ensembl chr 7:99,514,168...99,699,011
JBrowse link
G FEZF1 FEZ family zinc finger 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:24,881,850...24,884,790
Ensembl chr18:24,879,031...24,884,917
JBrowse link
G FEZF2 FEZ family zinc finger 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:43,953,914...43,958,419
Ensembl chr13:43,953,910...43,957,473
JBrowse link
G NANOG Nanog homeobox involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082
JBrowse link
G NCOA3 nuclear receptor coactivator 3 involved_in ISO (MGI:5440110|PMID:23019124) UniProt PMID:23019124 MGI:5440110 NCBI chr17:49,528,275...49,660,471
Ensembl chr17:49,528,179...49,663,200
JBrowse link
hepatocyte dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNRNPD heterogeneous nuclear ribonucleoprotein D ISO RGD PMID:20102719 RGD:10042969 NCBI chr 8:135,844,492...135,862,633
Ensembl chr 8:135,844,487...135,862,626
JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MIR214 microRNA mir-214 involved_in ISO (PMID:27144530) BHF-UCL PMID:27144530 NCBI chr 9:114,527,992...114,528,101
Ensembl chr 9:114,527,990...114,528,101
JBrowse link
G MIR221 microRNA mir-221 involved_in ISO (PMID:19088079) BHF-UCL PMID:19088079 NCBI chr  X:40,571,068...40,571,137
Ensembl chr  X:40,571,068...40,571,137
JBrowse link
G PDGFB platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:8,986,462...9,007,435 JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OLFM2 olfactomedin 2 involved_in ISO PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chr 2:68,734,078...68,807,207
Ensembl chr 2:68,734,081...68,807,191
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17808
    developmental process 6691
      dedifferentiation 11
        cell dedifferentiation 11
          cell dedifferentiation involved in phenotypic switching + 4
          hepatocyte dedifferentiation 1
          kidney cortex tubule cell dedifferentiation 0
paths to the root