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ONTOLOGY REPORT - ANNOTATIONS

Term:cell dedifferentiation
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Accession:GO:0043697 term browser browse the term
Definition:The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment:Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.


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cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin dependent kinase 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Esrrb estrogen related receptor, beta involved_in IDA (MGI:5882870|PMID:23040477) UniProt PMID:23040477 MGI:5882870 NCBI chr12:86,407,891...86,568,402
Ensembl chr12:86,407,891...86,568,402 		JBrowse link
G Fezf1 Fez family zinc finger 1 involved_in IGI (MGI:5905549|PMID:20152183) UniProt PMID:20152183 MGI:5905549 NCBI chr 6:23,245,043...23,250,942
Ensembl chr 6:23,245,043...23,248,361 		JBrowse link
G Fezf2 Fez family zinc finger 2 involved_in IGI (MGI:5905549|PMID:20152183) UniProt PMID:20152183 MGI:5905549 NCBI chr14:10,121,561...10,130,771
Ensembl chr14:10,121,574...10,127,669 		JBrowse link
G Nanog Nanog homeobox involved_in IDA (MGI:5882870|PMID:23040477) UniProt PMID:23040477 MGI:5882870 NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 involved_in IMP (MGI:5440110|PMID:23019124) UniProt PMID:23019124 MGI:5440110 NCBI chr 2:165,834,557...165,915,162
Ensembl chr 2:165,834,556...165,915,162 		JBrowse link
hepatocyte dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpd heterogeneous nuclear ribonucleoprotein D ISO RGD PMID:20102719 RGD:10042969 NCBI chr 5:100,103,794...100,126,926
Ensembl chr 5:100,103,794...100,126,797 		JBrowse link
negative regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir182 microRNA 182 involved_in ISO (PMID:28259995) BHF-UCL PMID:28259995 NCBI chr 6:30,165,917...30,165,991
Ensembl chr 6:30,165,917...30,165,991 		JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir214 microRNA 214 involved_in ISO (PMID:27144530) BHF-UCL PMID:27144530 NCBI chr 1:162,050,937...162,051,046
Ensembl chr 1:162,050,937...162,051,046 		JBrowse link
G Mir221 microRNA 221 involved_in ISO (PMID:19088079) BHF-UCL PMID:19088079 NCBI chr  X:19,012,533...19,012,627
Ensembl chr  X:19,012,533...19,012,627 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 9:20,578,986...20,657,660
Ensembl chr 9:20,578,986...20,657,645 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    developmental process 7363
      dedifferentiation 12
        cell dedifferentiation 12
          cell dedifferentiation involved in phenotypic switching + 5
          hepatocyte dedifferentiation 1
          kidney cortex tubule cell dedifferentiation 0
paths to the root