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ONTOLOGY REPORT - ANNOTATIONS

Term:cell dedifferentiation
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Accession:GO:0043697 term browser browse the term
Definition:The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
Comment:Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer.

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cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin dependent kinase 6 involved_in ISO (PMID:12861051) BHF-UCL PMID:12861051 NCBI chrNW_004955432:9,521,794...9,727,772
Ensembl chrNW_004955432:9,521,794...9,726,417 		JBrowse link
G Esrrb estrogen related receptor beta involved_in ISO (PMID:23040477) UniProt PMID:23040477 NCBI chrNW_004955438:365,375...534,086
Ensembl chrNW_004955438:365,137...534,666 		JBrowse link
G Fezf1 FEZ family zinc finger 1 involved_in ISO (PMID:20152183) UniProt PMID:20152183 NCBI chrNW_004955479:3,945,358...3,953,924
Ensembl chrNW_004955479:3,945,292...3,951,847 		JBrowse link
G Fezf2 FEZ family zinc finger 2 involved_in ISO (PMID:20152183) UniProt PMID:20152183 NCBI chrNW_004955517:3,439,999...3,443,477
Ensembl chrNW_004955517:3,439,999...3,443,846 		JBrowse link
G Nanog Nanog homeobox involved_in ISO (PMID:23040477) UniProt PMID:23040477 NCBI chrNW_004955413:6,561,323...6,565,770
Ensembl chrNW_004955413:6,562,275...6,565,463 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 involved_in ISO (PMID:23019124) UniProt PMID:23019124 NCBI chrNW_004955445:10,020,916...10,085,318
Ensembl chrNW_004955445:10,024,308...10,052,472 		JBrowse link
hepatocyte dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpd heterogeneous nuclear ribonucleoprotein D ISO RGD PMID:20102719 RGD:10042969 NCBI chrNW_004955433:6,452,931...6,470,209
Ensembl chrNW_004955433:6,454,454...6,469,904 		JBrowse link
positive regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfb platelet derived growth factor subunit B involved_in ISO (PMID:19088079) BHF-UCL PMID:19088079 NCBI chrNW_004955413:25,150,702...25,166,987
Ensembl chrNW_004955413:25,148,062...25,166,987 		JBrowse link
regulation of vascular associated smooth muscle cell dedifferentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olfm2 olfactomedin 2 involved_in ISO PMID:28062493 UniProt PMID:28062493 RGD:13441204 NCBI chrNW_004955495:1,264,831...1,328,877
Ensembl chrNW_004955495:1,264,831...1,328,877 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12722
    developmental process 6017
      dedifferentiation 9
        cell dedifferentiation 9
          cell dedifferentiation involved in phenotypic switching + 2
          hepatocyte dedifferentiation 1
          kidney cortex tubule cell dedifferentiation 0
paths to the root