P-type divalent copper transporter activity - Ontology Report

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Term:	P-type divalent copper transporter activity	go back to main search page
Accession:	GO:0043682	browse the term
Definition:	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out).
Synonyms:	exact_synonym:	copper-transporting ATPase activity
	broad_synonym:	copper transmembrane transporter activity, phosphorylative mechanism
	related_synonym:	Cu(2+)-exporting ATPase activity; Cu2+-exporting ATPase activity; copper-exporting ATPase activity; copper-translocating P-type ATPase activity
	alt_id:	GO:0004008
	xref:	EC:7.2.2.9; MetaCyc:TRANS-RXN-178; RHEA:10376; Reactome:R-HSA-6803545 "ATP7A transports cytosolic Cu2+ to phagosomal lumen"; Reactome:R-HSA-936802 "ATP7A transports cytosolic Cu2+ to extracellular region"; reactome:R-HSA-3697838 "ATP7A transfers Cu from ATOX1 to SOD3"; reactome:R-HSA-936895 "ATP7B transports cytosolic Cu2+ to Golgi lumen"

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Atp7a

ATPase copper transporting alpha

enables

GO_REF:0000033
(PMID:15634671)

GO_REF:0000033

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

ATPase copper transporting beta

enables

(PMID:9837819)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
MGI:1856220 (PMID:11237756), (PMID:15634671)

GO_REF:0000024 GO_REF:0000033 GO_REF:0000107

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

Term paths to the root

Path 1
Term	Annotations
molecular_function	20634
ATP-dependent activity	629
ATPase-coupled transmembrane transporter activity	118
ATPase-coupled monoatomic cation transmembrane transporter activity	65
P-type divalent copper transporter activity	2
Path 2
Term	Annotations
molecular_function	20634
transporter activity	1253
transmembrane transporter activity	1153
monoatomic ion transmembrane transporter activity	762
monoatomic cation transmembrane transporter activity	642
metal ion transmembrane transporter activity	456
transition metal ion transmembrane transporter activity	43
copper ion transmembrane transporter activity	8
P-type divalent copper transporter activity	2

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