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ONTOLOGY REPORT - ANNOTATIONS

Term:PCNA complex
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Accession:GO:0043626 term browser browse the term
Definition:A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.
Synonyms:exact_synonym: PCNA homotrimer;   proliferating cell nuclear antigen complex
 broad_synonym: sliding clamp


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PCNA complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcna proliferating cell nuclear antigen part_of
located_in		 ISO
ISS
IBA		 (PMID:24939902)
GO_REF:0000024
(PMID:15681588)
GO_REF:0000114
GO_REF:0000033		 RGD
UniProt
ComplexPortal
GO_Central		 PMID:15681588 PMID:24939902 GO_REF:0000024 GO_REF:0000033 GO_REF:0000114 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21254
    protein-containing complex 6911
      nuclear protein-containing complex 1373
        PCNA complex 1
Path 2
Term Annotations click to browse term
  cellular_component 21254
    cellular anatomical entity 21098
      intracellular anatomical structure 15550
        intracellular organelle 13782
          intracellular membrane-bounded organelle 12228
            nucleus 7659
              nuclear protein-containing complex 1373
                PCNA complex 1
paths to the root