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ONTOLOGY REPORT - ANNOTATIONS


Term:nuclear replisome
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Accession:GO:0043601 term browser browse the term
Definition:A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.



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alpha DNA polymerase:primase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pola1 DNA polymerase alpha 1, catalytic subunit located_in
part_of
IDA
ISO
IBA
IEA
ISS
IC
(MGI:3687659|PMID:10523676)
(PMID:26975377)
(PMID:2175912), (PMID:22465957), (PMID:26975377), (PMID:8026492)
(MGI:1203906|PMID:9584195), (MGI:6478526|PMID:8026492)
PMID:21873635
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:2175912 PMID:8026492 PMID:9584195 PMID:10523676 PMID:22465957 More... GO_REF:0000024 GO_REF:0000107 MGI:1203906 MGI:3687659 MGI:6478526, RGD:1580605, RGD:13792537, RGD:2307013 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit located_in
part_of
TAS
ISO
ISS
IEA
IBA
IC
(MGI:3687659|PMID:10523676)
(PMID:26975377)
GO_REF:0000024
(PMID:22465957), (PMID:26975377), (PMID:8026492)
(MGI:1203906|PMID:9584195), (MGI:6478526|PMID:8026492)
GO_REF:0000107
PMID:21873635
RGD
UniProt
Ensembl
PMID:8026492 PMID:9584195 PMID:10523676 PMID:22465957 PMID:26975377 More... GO_REF:0000024 GO_REF:0000107 MGI:1203906 MGI:3687659 MGI:6478526, RGD:633584, RGD:13792537, RGD:2307013 NCBI chr 1:203,227,183...203,251,350
Ensembl chr 1:203,203,388...203,251,348
JBrowse link
G Prim1 DNA primase subunit 1 part_of
located_in
IBA
ISO
PMID:21873635
(MGI:3687659|PMID:10523676)
(PMID:26975377)
(PMID:26975377), (PMID:8026492)
(MGI:6478526|PMID:8026492)
RGD PMID:8026492 PMID:10523676 PMID:26975377 PMID:21873635 MGI:3687659 MGI:6478526, RGD:13792537 NCBI chr 7:446,342...462,526
Ensembl chr 7:431,805...462,526
JBrowse link
G Prim2 DNA primase subunit 2 part_of
located_in
IBA
ISO
ISS
PMID:21873635
(MGI:3687659|PMID:10523676)
(PMID:26975377)
GO_REF:0000024
(PMID:26975377), (PMID:8026492)
(MGI:6478526|PMID:8026492)
RGD
UniProt
PMID:8026492 PMID:10523676 PMID:26975377 PMID:21873635 GO_REF:0000024 MGI:3687659 MGI:6478526, RGD:13792537 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030
JBrowse link
delta DNA polymerase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pola1 DNA polymerase alpha 1, catalytic subunit part_of IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit part_of
located_in
IC
IEA
ISO
IBA
IDA
GO_REF:0000117
(PMID:12403614)
(MGI:6383350|PMID:11595739)
PMID:21873635
(PMID:11595739), (PMID:22465957)
UniProt
RGD
PMID:11595739 PMID:12403614 PMID:22465957 PMID:7503737 PMID:21873635 More... GO_REF:0000117 MGI:6383350, RGD:2307013, RGD:13792537, RGD:729526 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
JBrowse link
G Pold2 DNA polymerase delta 2, accessory subunit located_in
part_of
IC
ISO
IBA
IDA
(PMID:12403614)
(MGI:6383350|PMID:11595739)
PMID:21873635
(PMID:11595739), (PMID:22465957)
RGD PMID:11595739 PMID:12403614 PMID:22465957 PMID:7503737 PMID:21873635 More... MGI:6383350, RGD:2307013, RGD:13792537, RGD:729526 NCBI chr14:80,748,971...80,755,188
Ensembl chr14:80,748,974...80,755,160
JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit part_of
located_in
IC
ISO
IBA
(PMID:11595739), (PMID:22465957)
PMID:21873635
(MGI:6383350|PMID:11595739)
(PMID:12403614)
RGD PMID:11595739 PMID:12403614 PMID:22465957 PMID:7503737 PMID:21873635 MGI:6383350, RGD:2307013, RGD:13792537 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
JBrowse link
G Pold4 DNA polymerase delta 4, accessory subunit located_in
part_of
IC
ISO
IBA
(PMID:12403614)
PMID:21873635
RGD PMID:12403614 PMID:7503737 PMID:21873635 RGD:2307013, RGD:13792537 NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit part_of IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
JBrowse link
DNA replication factor A complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcas2 BCAS2, pre-mRNA processing factor colocalizes_with
part_of
ISO
IEA
(PMID:24332808)
GO_REF:0000107
RGD
Ensembl
PMID:24332808 GO_REF:0000107 NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
JBrowse link
G Cdc5l cell division cycle 5-like colocalizes_with ISO
ISS
(PMID:24332808)
GO_REF:0000024
RGD
UniProt
PMID:24332808 GO_REF:0000024 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease colocalizes_with ISO (PMID:7700386) RGD PMID:7700386 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Helb DNA helicase B colocalizes_with
part_of
ISO
IEA
(PMID:26774285)
GO_REF:0000107
RGD
Ensembl
PMID:26774285 GO_REF:0000107 NCBI chr 7:55,588,510...55,615,979
Ensembl chr 7:55,588,798...55,615,585
JBrowse link
G LOC100362927 replication protein A3-like part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:45,908,653...45,909,063
Ensembl chr12:45,908,683...45,909,048
JBrowse link
G Plrg1 pleiotropic regulator 1 colocalizes_with ISO
ISS
(PMID:24332808)
GO_REF:0000024
RGD
UniProt
PMID:24332808 GO_REF:0000024 NCBI chr 2:168,408,139...168,424,470
Ensembl chr 2:168,408,124...168,424,522
JBrowse link
G Prpf19 pre-mRNA processing factor 19 colocalizes_with ISO
ISS
(PMID:24332808)
GO_REF:0000024
RGD
UniProt
PMID:24332808 GO_REF:0000024 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662
JBrowse link
G Rpa1 replication protein A1 located_in
part_of
IDA
ISO
IBA
(PMID:11927569), (PMID:7760808)
UniProtKB:P15927 (PMID:11927569), (PMID:16135809), (PMID:27723717), (PMID:27723720)
PMID:21873635
RGD PMID:7760808 PMID:11927569 PMID:16135809 PMID:27723717 PMID:27723720 More... RGD:2307012, RGD:13792537, RGD:2307013 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G Rpa2 replication protein A2 located_in
part_of
IDA
ISO
IBA
(PMID:11927569)
UniProtKB:P27694 (PMID:11927569), (PMID:16135809), (PMID:2406247), (PMID:27723717), (PMID:27723720)
PMID:21873635
RGD PMID:2406247 PMID:11927569 PMID:16135809 PMID:27723717 PMID:27723720 More... RGD:2307012, RGD:13792537, RGD:2307013 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rpa3 replication protein A3 located_in
part_of
IDA
ISO
IBA
(PMID:11927569), (PMID:7760808)
PMID:21873635
RGD PMID:7760808 PMID:11927569 PMID:7503737 PMID:21873635 RGD:2307013, RGD:13792537 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
JBrowse link
G Smarcal1 Swi/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 colocalizes_with ISS
ISO
GO_REF:0000024
(PMID:19793862), (PMID:19793863)
UniProt
RGD
PMID:19793862 PMID:19793863 GO_REF:0000024 NCBI chr 9:74,239,718...74,286,156
Ensembl chr 9:74,240,241...74,286,146
JBrowse link
G Tonsl tonsoku-like, DNA repair protein colocalizes_with ISO
ISS
(PMID:21055983)
GO_REF:0000024
RGD
UniProt
PMID:21055983 GO_REF:0000024 NCBI chr 7:108,345,704...108,360,792
Ensembl chr 7:108,346,047...108,360,750
JBrowse link
G Xpa XPA, DNA damage recognition and repair factor colocalizes_with ISO (PMID:7700386) RGD PMID:7700386 NCBI chr 5:60,431,673...60,476,438
Ensembl chr 5:60,431,673...60,475,726
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6133
      nuclear protein-containing complex 1290
        nuclear replisome 22
          DNA replication factor A complex 13
          alpha DNA polymerase:primase complex 4
          delta DNA polymerase complex 6
          nuclear DNA replication factor C complex + 0
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19686
      organelle 13035
        membrane-bounded organelle 11682
          intracellular membrane-bounded organelle 11208
            nucleus 7044
              nuclear lumen 3932
                nuclear chromosome 243
                  nuclear replication fork 36
                    nuclear replisome 22
                      DNA replication factor A complex 13
                      alpha DNA polymerase:primase complex 4
                      delta DNA polymerase complex 6
                      nuclear DNA replication factor C complex + 0
paths to the root