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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor substrate binding
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Accession:GO:0043560 term browser browse the term
Definition:Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
Synonyms:exact_synonym: IRS [protein] binding;   IRS binding;   insulin receptor substrate [protein] binding


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insulin receptor substrate binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1299201
RGD:1624291
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:1581313
RGD:1600115
RGD:13792537
RGD:1624291
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:1580595
RGD:13792537
RGD:1624291
RGD:1600115
G Insrr insulin receptor-related receptor JBrowse link 2 187,161,817 187,181,400 RGD:13792537
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1641881
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:1624291
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:1624291
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:1299201
RGD:1600115
RGD:1624291
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:1299201
G Wdr6 WD repeat domain 6 JBrowse link 8 117,358,345 117,364,761 RGD:2301084

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Term Annotations click to browse term
  molecular_function 20377
    binding 16798
      protein binding 14233
        insulin receptor substrate binding 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.