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ONTOLOGY REPORT - ANNOTATIONS


Term:insulin receptor substrate binding
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Accession:GO:0043560 term browser browse the term
Definition:Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.
Synonyms:exact_synonym: IRS [protein] binding;   IRS binding;   insulin receptor substrate [protein] binding



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insulin receptor substrate binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grb2 growth factor receptor bound protein 2 enables IPI
ISO
UniProtKB:P35568 (PMID:8388384) RGD PMID:8388384 PMID:12891559 PMID:12891559 RGD:1299201, RGD:1299201 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Igf1r insulin-like growth factor 1 receptor enables IPI
ISS
IEA
ISO
IBA
GO_REF:0000024
GO_REF:0000107
UniProtKB:P35568 (PMID:7541045)
PMID:21873635
UniProt
Ensembl
RGD
PMID:7541045 PMID:15272025 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:1581313, RGD:13792537 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Insr insulin receptor enables IMP
ISO
IEA
IBA
UniProtKB:P35568 (PMID:7493946), (PMID:7537849), (PMID:7559478)
GO_REF:0000002
GO_REF:0000107
PMID:21873635
RGD
InterPro
Ensembl
PMID:7493946 PMID:7537849 PMID:7559478 PMID:12850498 PMID:21873635 GO_REF:0000002 GO_REF:0000107, RGD:1580595, RGD:13792537 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Insrr insulin receptor-related receptor enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800
JBrowse link
G Jak2 Janus kinase 2 IPI RGD PMID:15701573 RGD:1641881 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha enables ISO MGI:109334|PR:P35569 (MGI:3626116|PMID:12486171) RGD PMID:12486171 MGI:3626116 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta enables IEA
ISO
GO_REF:0000107
MGI:109334|PR:P35569 (MGI:3625596|PMID:16625210)
Ensembl
RGD
PMID:16625210 GO_REF:0000107 MGI:3625596 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 enables IPI
ISO
IEA
ISS
UniProtKB:P35568 (MGI:3689804|PMID:16043515)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16043515 PMID:12891559 PMID:12891559 GO_REF:0000024 GO_REF:0000107 MGI:3689804, RGD:1299201, RGD:1299201 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Prkcd protein kinase C, delta enables IEA
ISO
GO_REF:0000107
UniProtKB:P35570 (MGI:3836105|PMID:18285345)
Ensembl
RGD
PMID:18285345 GO_REF:0000107 MGI:3836105 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 IPI RGD PMID:12891559 RGD:1299201 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Wdr6 WD repeat domain 6 IPI RGD PMID:17720279 RGD:2301084 NCBI chr 8:109,268,079...109,274,504
Ensembl chr 8:109,268,079...109,274,499
JBrowse link

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  molecular_function 20203
    binding 17217
      protein binding 14511
        insulin receptor substrate binding 11
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