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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of translation in response to stress
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Accession:GO:0043555 term browser browse the term
Definition:Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
Synonyms:exact_synonym: translational stress response

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eiF2alpha phosphorylation in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6467680|PMID:17707796)
(PMID:25329545)		 UniProt
RGD		 PMID:17707796 PMID:25329545 GO_REF:0000024 MGI:6467680 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (PMID:25329545) RGD PMID:25329545 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217 		JBrowse link
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 involved_in ISO
ISS		 (PMID:22064321)
(MGI:5617428|PMID:25329545)
GO_REF:0000024		 RGD
UniProt		 PMID:22064321 PMID:25329545 GO_REF:0000024 MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213), (PMID:16835242)
UniProtKB:O55033 (MGI:5613475|PMID:16835242), (MGI:5613478|PMID:14676213)		 RGD PMID:14676213 PMID:16835242 MGI:5613475 MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO (PMID:16835242)
UniProtKB:Q99M51 (MGI:5613475|PMID:16835242), (MGI:5613478|PMID:14676213)		 RGD PMID:14676213 PMID:16835242 MGI:5613475 MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A involved_in ISO (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B involved_in ISO (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297 		JBrowse link
negative regulation of translation in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:1333015|PMID:9930704) RGD PMID:9930704 MGI:1333015 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Sesn2 sestrin 2 involved_in ISO (PMID:24947615)
(MGI:5688277|PMID:24947615)		 RGD PMID:24947615 MGI:5688277 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117 		JBrowse link
negative regulation of translation in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pml PML nuclear body scaffold involved_in ISO (PMID:16915281) RGD PMID:16915281 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226 		JBrowse link
negative regulation of translation in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 IDA RGD PMID:9819435 RGD:70729 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Rbm4 RNA binding motif protein 4 involved_in ISO (PMID:17284590) RGD PMID:17284590 NCBI chr 1:220,038,403...220,049,756
Ensembl chr 1:220,039,734...220,048,966 		JBrowse link
negative regulation of translational initiation in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO (MGI:5700311|PMID:12176355) RGD PMID:12176355 MGI:5700311 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISS
ISO		 GO_REF:0000024
(MGI:5700311|PMID:12176355)		 UniProt
RGD		 PMID:12176355 GO_REF:0000024 MGI:5700311 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A involved_in ISO (PMID:21518769) RGD PMID:21518769 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
positive regulation of translation in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:29062139) RGD PMID:29062139 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995 		JBrowse link
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 involved_in ISO (PMID:29062139) RGD PMID:29062139 NCBI chr11:83,907,659...83,927,683
Ensembl chr11:83,908,109...83,926,524 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
UniProtKB:O55033 (MGI:5613478|PMID:14676213)		 RGD PMID:14676213 MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO UniProtKB:Q99M51 (MGI:5613478|PMID:14676213) RGD PMID:14676213 MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284 		JBrowse link
positive regulation of translation in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc35a4 solute carrier family 35, member A4 involved_in ISO (PMID:25621764) RGD PMID:25621764 NCBI chr18:29,505,239...29,509,304
Ensembl chr18:29,506,128...29,509,296 		JBrowse link
positive regulation of translation initiation in response to endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5617428|PMID:25329545)		 UniProt
RGD		 PMID:25329545 GO_REF:0000024 MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329 		JBrowse link
positive regulation of translational initiation in response to starvation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2149467|PMID:10655230), (MGI:3589053|PMID:16121183)		 UniProt
RGD		 PMID:10655230 PMID:16121183 GO_REF:0000024 MGI:2149467 MGI:3589053 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217 		JBrowse link
G Impact impact RWD domain protein involved_in ISS
ISO		 GO_REF:0000024
(MGI:5494763|PMID:23447528)		 UniProt
RGD		 PMID:23447528 GO_REF:0000024 MGI:5494763 NCBI chr18:4,325,872...4,346,734
Ensembl chr18:4,325,875...4,346,769 		JBrowse link
regulation of eIF2 alpha phosphorylation by dsRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Npm1 nucleophosmin 1 involved_in ISO
ISS		 (PMID:12882984)
GO_REF:0000024		 RGD
UniProt		 PMID:12882984 GO_REF:0000024 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950 		JBrowse link
regulation of eIF2 alpha phosphorylation by heme term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 acts_upstream_of_or_within ISO MGI:1353448|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146 		JBrowse link
G Fech ferrochelatase acts_upstream_of_or_within ISO MGI:1353448|MGI:1858114|MGI:95513 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192 		JBrowse link
G Hbb hemoglobin subunit beta acts_upstream_of_or_within ISO MGI:1857179 (MGI:3581470|PMID:15931390) RGD PMID:15931390 MGI:3581470 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725 		JBrowse link
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3582244|PMID:11106749)		 UniProt
RGD		 PMID:11106749 GO_REF:0000024 MGI:3582244 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A involved_in ISO (MGI:5605960|PMID:11381086) RGD PMID:11381086 MGI:5605960 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
regulation of translational initiation by eIF2 alpha dephosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A involved_in ISO (PMID:12556489) RGD PMID:12556489 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
regulation of translational initiation by eIF2 alpha phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr12:12,749,026...12,782,078
Ensembl chr12:12,748,785...12,782,146 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:1858648|PMID:10882126), (MGI:3582244|PMID:11106749), (MGI:3722921|PMID:14729979), (MGI:5613478|PMID:14676213) RGD PMID:10882126 PMID:11106749 PMID:14676213 PMID:14729979 MGI:1858648 MGI:3582244 MGI:3722921 MGI:5613478 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q9Z2B5 (MGI:2149467|PMID:10655230), (MGI:3582244|PMID:11106749), (MGI:3589053|PMID:16121183), (MGI:3722921|PMID:14729979), (MGI:5700278|PMID:26102367), (MGI:5700304|PMID:16601681), (MGI:5700311|PMID:12176355)
(PMID:26102367)		 UniProt
RGD		 PMID:10655230 PMID:11106749 PMID:12176355 PMID:14729979 PMID:16121183 PMID:16601681 PMID:26102367 GO_REF:0000024 MGI:2149467 MGI:3582244 MGI:3589053 MGI:3722921 MGI:5700278 MGI:5700304 MGI:5700311 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217 		JBrowse link
regulation of translational initiation in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 acts_upstream_of_or_within ISO (MGI:3589702|PMID:15937339) RGD PMID:15937339 MGI:3589702 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha acts_upstream_of_or_within ISO (MGI:3589702|PMID:15937339) RGD PMID:15937339 MGI:3589702 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    cellular process 18481
      cellular response to stimulus 8791
        cellular response to stress 1969
          regulation of translation in response to stress 22
            negative regulation of translation in response to stress + 7
            positive regulation of translation in response to stress + 8
            regulation of cytoplasmic translation in response to stress + 0
            regulation of translation in response to endoplasmic reticulum stress + 11
            regulation of translation in response to osmotic stress + 0
            regulation of translation in response to oxidative stress + 1
            regulation of translational initiation in response to stress + 16
Path 2
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      biosynthetic process 6181
        cellular biosynthetic process 6026
          cellular nitrogen compound biosynthetic process 5020
            amide biosynthetic process 1240
              peptide biosynthetic process 1120
                translation 1100
                  regulation of translation 404
                    regulation of translation in response to stress 22
                      negative regulation of translation in response to stress + 7
                      positive regulation of translation in response to stress + 8
                      regulation of cytoplasmic translation in response to stress + 0
                      regulation of translation in response to endoplasmic reticulum stress + 11
                      regulation of translation in response to osmotic stress + 0
                      regulation of translation in response to oxidative stress + 1
                      regulation of translational initiation in response to stress + 16
paths to the root