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ONTOLOGY REPORT - ANNOTATIONS


Term:6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
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Accession:GO:0043540 term browser browse the term
Definition:A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.
Comment:Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future.
Synonyms:narrow_synonym: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex;   6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex


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6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 part_of IDA
ISS
ISO
IBA
GO_REF:0000024
(PMID:12379646)
PMID:21873635
UniProt
RGD
PMID:12379646 PMID:7619077 PMID:21873635 GO_REF:0000024, RGD:2302679, RGD:13792537 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
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Path 1
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  cellular_component 20010
    cellular anatomical entity 19714
      cytosol 4227
        6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20010
    cellular anatomical entity 19714
      intracellular anatomical structure 14388
        cytoplasm 11359
          cytosol 4227
            6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex 1
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