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ONTOLOGY REPORT - ANNOTATIONS


Term:interleukin-12 complex
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Accession:GO:0043514 term browser browse the term
Definition:A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
Comment:Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
Synonyms:exact_synonym: IL-12 complex
 narrow_synonym: IL12A;   IL12B;   p35;   p40



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interleukin-12 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12a interleukin 12A part_of
located_in
ISO (PMID:11023671)
(PMID:10899108)
MGI:96540 (MGI:3050756|PMID:15220916), (MGI:63529|PMID:7690439)
(PMID:11023671), (PMID:11114383), (PMID:2204066)
RGD PMID:2204066 PMID:7690439 PMID:10899108 PMID:11023671 PMID:11114383 More... MGI:3050756 MGI:63529 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B part_of
located_in
IDA
ISO
IBA
(PMID:11114383), (PMID:1674604)
PMID:21873635
MGI:96539 (MGI:3050756|PMID:15220916), (MGI:63529|PMID:7690439)
(PMID:10899108)
RGD PMID:1674604 PMID:7690439 PMID:10899108 PMID:11114383 PMID:15220916 More... MGI:3050756 MGI:63529, RGD:1600058, RGD:13792537 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19189
    protein-containing complex 5927
      interleukin-12 complex 2
Path 2
Term Annotations click to browse term
  cellular_component 19189
    cellular anatomical entity 18930
      extracellular region 2360
        extracellular space 1730
          interleukin-12 complex 2
paths to the root