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Term:interleukin-12 complex
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Accession:GO:0043514 term browser browse the term
Definition:A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.
Comment:Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain.
Synonyms:exact_synonym: IL-12 complex
 narrow_synonym: IL12A;   IL12B;   p35;   p40

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interleukin-12 complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12a interleukin 12A part_of ISO
MGI:96540 (MGI:3050756|PMID:15220916), (MGI:63529|PMID:7690439)
(PMID:11023671), (PMID:11114383), (PMID:2204066)
PMID:2204066 PMID:7690439 PMID:11023671 PMID:11114383 PMID:15220916 GO_REF:0000107 MGI:3050756 MGI:63529 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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G Il12b interleukin 12B part_of IDA
(PMID:11114383), (PMID:1674604)
MGI:96539 (MGI:3050756|PMID:15220916), (MGI:63529|PMID:7690439)
RGD PMID:1674604 PMID:7690439 PMID:11114383 PMID:15220916, PMID:16716808, PMID:21873635 MGI:3050756 MGI:63529, RGD:1600058, RGD:13792537 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20142
    protein-containing complex 6031
      interleukin-12 complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20142
    cellular anatomical entity 19842
      extracellular region 2497
        extracellular space 1863
          interleukin-12 complex 2
paths to the root