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ONTOLOGY REPORT - ANNOTATIONS

Term:malate-aspartate shuttle
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Accession:GO:0043490 term browser browse the term
Definition:The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
Synonyms:xref: Wikipedia:Malate-aspartate_shuttle


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malate-aspartate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC1A3 solute carrier family 1 member 3 ISO RGD PMID:15242733 RGD:1642939 NCBI chr 4:71,936,128...72,014,119
Ensembl chr 4:71,936,126...72,014,173 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:17213189) RGD
Ensembl
UniProt
TreeGrafter
MGI		 PMID:17213189 PMID:19764902 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:13628741 NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016 		JBrowse link
G SLC25A13 solute carrier family 25 member 13 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17213189) UniProt
TreeGrafter
MGI		 PMID:17213189 GO_REF:0000117 GO_REF:0000118 NCBI chr14:21,295,651...21,481,767
Ensembl chr14:21,296,512...21,482,236 		JBrowse link
G SLC25A18 solute carrier family 25 member 18 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr27:45,196,172...45,221,751
Ensembl chr27:45,196,670...45,221,297 		JBrowse link
G SLC25A22 solute carrier family 25 member 22 involved_in IEA TreeGrafter GO_REF:0000118
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      transmembrane transport 1608
        mitochondrial transmembrane transport 105
          malate-aspartate shuttle 5
Path 2
Term Annotations click to browse term
  biological_process 17917
    cellular process 16926
      cellular metabolic process 9218
        generation of precursor metabolites and energy 488
          energy derivation by oxidation of organic compounds 342
            cellular respiration 245
              respiratory electron transport chain 117
                malate-aspartate shuttle 5
paths to the root