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Term:malate-aspartate shuttle
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Accession:GO:0043490 term browser browse the term
Definition:The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
Synonyms:xref: Wikipedia:Malate-aspartate_shuttle

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malate-aspartate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a3 solute carrier family 1 member 3 IDA RGD PMID:15242733 RGD:1642939 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
G Slc25a12 solute carrier family 25 member 12 involved_in
MGI:3603462 (MGI:3708219|PMID:17213189)
RGD PMID:11566871 PMID:17213189 PMID:19764902 PMID:21873635 MGI:3708219, RGD:13628741, RGD:13792537 NCBI chr 3:56,098,080...56,192,188
Ensembl chr 3:56,097,269...56,192,100
JBrowse link
G Slc25a13 solute carrier family 25 member 13 involved_in
ISO (PMID:11566871)
MGI:3530352 (MGI:3708219|PMID:17213189)
RGD PMID:11566871 PMID:17213189 MGI:3708219 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
JBrowse link
G Slc25a18 solute carrier family 25 member 18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:154,000,808...154,021,373
Ensembl chr 4:154,000,990...154,021,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    cellular process 17330
      transmembrane transport 1710
        mitochondrial transmembrane transport 66
          malate-aspartate shuttle 4
Path 2
Term Annotations click to browse term
  biological_process 19738
    metabolic process 12010
      cellular metabolic process 7444
        generation of precursor metabolites and energy 548
          energy derivation by oxidation of organic compounds 366
            cellular respiration 270
              respiratory electron transport chain 133
                malate-aspartate shuttle 4
paths to the root