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ONTOLOGY REPORT - ANNOTATIONS


Term:malate-aspartate shuttle
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Accession:GO:0043490 term browser browse the term
Definition:The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.
Synonyms:xref: Wikipedia:Malate-aspartate_shuttle


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malate-aspartate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc1a3 solute carrier family 1 member 3 IDA RGD PMID:15242733 RGD:1642939 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
G Slc25a12 solute carrier family 25 member 12 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
MGI:3603462 (MGI:3708219|PMID:17213189)
(PMID:11566871)
PMID:21873635
RGD PMID:11566871 PMID:17213189 PMID:19764902 PMID:21873635 MGI:3708219, RGD:13628741, RGD:13792537 NCBI chr 3:56,098,080...56,192,188
Ensembl chr 3:56,097,269...56,192,100
JBrowse link
G Slc25a13 solute carrier family 25 member 13 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3530352 (MGI:3708219|PMID:17213189)
(PMID:11566871)
RGD PMID:11566871 PMID:17213189 PMID:21873635 MGI:3708219, RGD:13792537 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
JBrowse link
G Slc25a18 solute carrier family 25 member 18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:154,000,808...154,021,373
Ensembl chr 4:154,000,990...154,021,372
JBrowse link
G Slc25a22 solute carrier family 25 member 22 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:196,528,471...196,536,398
Ensembl chr 1:196,528,472...196,536,331
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19494
    cellular process 18342
      transmembrane transport 1582
        mitochondrial transmembrane transport 101
          malate-aspartate shuttle 5
Path 2
Term Annotations click to browse term
  biological_process 19494
    cellular process 18342
      cellular metabolic process 10718
        generation of precursor metabolites and energy 502
          energy derivation by oxidation of organic compounds 330
            cellular respiration 240
              respiratory electron transport chain 112
                malate-aspartate shuttle 5
paths to the root