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ONTOLOGY REPORT - ANNOTATIONS

Term:malate-aspartate shuttle
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Accession:GO:0043490 term browser browse the term
Definition:The process of transferring reducing equivalents from NADH in the cytosol to the mitochondria via malate. Cytosolic aspartate aminotransferase converts aspartate to oxaloacetate, and cytosolic malate dehydrogenase uses NADH to convert oxaloacetate to malate in the cytosol; the malate-alpha-ketoglutarate carrier then transports the malate into the mitochondria where mitochondrial malate dehydrogenase uses NAD to convert malate back to oxaloacetate; the electrons on the reduced NADH are then available for use in the electron transport chain; mitochondrial aspartate aminotransferase converts oxaloacetate to aspartate, and the glutamate-aspartate carrier transports the aspartate back to the cytosol to complete the cycle.
Synonyms:xref: MetaCyc:MALATE-ASPARTATE-SHUTTLE-PWY;   Reactome:R-HSA-9856872 "Malate-aspartate shuttle";   Wikipedia:Malate-aspartate_shuttle


show annotations for term's descendants           Sort by:
malate-aspartate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1 involved_in ISO
IEA		 (PMID:37813964)
(PMID:37647199)
GO_REF:0000107		 RGD
Ensembl		 PMID:37647199 PMID:37813964 GO_REF:0000107 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 involved_in ISO (PMID:34450065)
(PMID:37647199)		 RGD PMID:34450065 PMID:37647199 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994 		JBrowse link
G Mdh1 malate dehydrogenase 1 involved_in ISO
IEA		 (PMID:32396938)
(PMID:37647199)
GO_REF:0000107		 RGD
Ensembl		 PMID:32396938 PMID:37647199 GO_REF:0000107 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh2 malate dehydrogenase 2 involved_in ISO (PMID:24134846)
(PMID:37647199)		 RGD PMID:24134846 PMID:37647199 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 IDA RGD PMID:15242733 RGD:1642939 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
G Slc25a11 solute carrier family 25 member 11 involved_in ISO
IEA		 (PMID:31217581)
(PMID:37647199)
GO_REF:0000107		 RGD
Ensembl		 PMID:31217581 PMID:37647199 GO_REF:0000107 NCBI chr10:55,357,590...55,360,441
Ensembl chr10:55,357,597...55,360,410 		JBrowse link
G Slc25a12 solute carrier family 25 member 12 involved_in
acts_upstream_of_or_within		 IMP
IEA
ISO
IBA		 GO_REF:0000117
MGI:3603462 (PMID:17213189)
MGI:1354721|MGI:3603462 (PMID:15987682), (PMID:17213189), (PMID:36967723)
UniProtKB:Q9UJS0 (PMID:11566871), (PMID:37647199)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:11566871 PMID:15987682 PMID:17213189 PMID:36967723 PMID:37647199 More... GO_REF:0000033 GO_REF:0000117, RGD:13628741 NCBI chr 3:56,097,166...56,191,841
Ensembl chr 3:56,097,269...56,192,100 		JBrowse link
G Slc25a13 solute carrier family 25 member 13 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000117
MGI:3530352 (PMID:17213189)
UniProtKB:O75746 (PMID:11566871), (PMID:37647199)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:11566871 PMID:17213189 PMID:37647199 GO_REF:0000033 GO_REF:0000117 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902 		JBrowse link
G Slc25a18 solute carrier family 25 member 18 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:154,000,808...154,021,373
Ensembl chr 4:154,000,990...154,021,372 		JBrowse link
G Slc25a22 solute carrier family 25 member 22 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:196,528,471...196,536,398
Ensembl chr 1:196,528,472...196,536,331 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20537
    cellular process 19526
      metabolic process 12168
        purine-containing compound metabolic process 618
          purine nucleotide metabolic process 480
            NAD metabolic process 66
              NADH metabolic process 44
                NADH oxidation 18
                  malate-aspartate shuttle 10
Path 2
Term Annotations click to browse term
  biological_process 20537
    cellular process 19526
      metabolic process 12168
        primary metabolic process 10755
          nucleobase-containing compound metabolic process 5945
            nucleobase-containing small molecule metabolic process 730
              nucleoside phosphate metabolic process 695
                nucleotide metabolic process 541
                  pyridine nucleotide metabolic process 237
                    nicotinamide nucleotide metabolic process 237
                      NAD metabolic process 66
                        NADH metabolic process 44
                          NADH oxidation 18
                            malate-aspartate shuttle 10
paths to the root