Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of MAP kinase activity
go back to main search page
Accession:GO:0043407 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
Synonyms:exact_synonym: down regulation of MAPK activity;   downregulation of MAPK activity;   negative regulation of mitogen activated protein kinase activity
 narrow_synonym: inhibition of MAPK activity



show annotations for term's descendants           Sort by:
 
negative regulation of MAP kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO
GO_REF:0000024
(MGI:4943654|PMID:19460854)
UniProt
RGD
PMID:19460854 GO_REF:0000024 MGI:4943654 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agt angiotensinogen involved_in ISO (PMID:28283184) RGD PMID:28283184 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:9685360)
GO_REF:0000107
RGD
Ensembl
PMID:9685360 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of
involved_in
ISO
IEA
(PMID:18382765)
GO_REF:0000107
RGD
Ensembl
PMID:18382765 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:17244894)
UniProt
Ensembl
RGD
PMID:17244894 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO (PMID:17244894) RGD PMID:17244894 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO MGI:2180364 (MGI:3703676|PMID:12388746) RGD PMID:12388746 MGI:3703676 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cav3 caveolin 3 involved_in ISO (PMID:12847114) RGD PMID:12847114 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Cblc Cbl proto-oncogene C involved_in ISO (PMID:10362357) RGD PMID:10362357 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755
JBrowse link
G Cd300a Cd300a molecule involved_in ISO (PMID:16254138) RGD PMID:16254138 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
ISS
(PMID:21283629)
GO_REF:0000024
RGD
UniProt
PMID:21283629 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
ISS
(PMID:12813029), (PMID:20154697)
GO_REF:0000024
RGD
UniProt
PMID:12813029 PMID:20154697 GO_REF:0000024 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISO
ISS
(PMID:7593328)
GO_REF:0000024
RGD
UniProt
PMID:7593328 GO_REF:0000024 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp7 dual specificity phosphatase 7 involved_in ISO (PMID:9788880) RGD PMID:9788880 NCBI chr 8:107,009,369...107,016,404
Ensembl chr 8:107,008,528...107,016,404
JBrowse link
G Fem1a fem-1 homolog A acts_upstream_of_or_within ISO (MGI:3790904|PMID:18270204) RGD PMID:18270204 MGI:3790904 NCBI chr 9:1,091,695...1,093,901
Ensembl chr 9:1,090,527...1,100,628
JBrowse link
G Gba glucosylceramidase beta involved_in ISO (PMID:19279008) RGD PMID:19279008 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IMP RGD PMID:17182785 RGD:2301767 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO (PMID:11408560) RGD PMID:11408560 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase acts_upstream_of_or_within ISO MGI:97306 (MGI:3610917|PMID:12409258) RGD PMID:12409258 MGI:3610917 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hyal2 hyaluronidase 2 involved_in ISO
IEA
ISS
(PMID:12676986)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:12676986 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850
JBrowse link
G Il1b interleukin 1 beta involved_in ISO (MGI:3828398|PMID:16865359) RGD PMID:16865359 MGI:3828398 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in ISO (PMID:12556481) RGD PMID:12556481 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:12933696 RGD:1626126 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in IBA
ISO
PMID:21873635
(MGI:3843426|PMID:17379480)
(PMID:17379480)
RGD PMID:17379480 PMID:21873635 MGI:3843426, RGD:13792537 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Kng2 kininogen 2 IDA in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
JBrowse link
G Lax1 lymphocyte transmembrane adaptor 1 involved_in ISO (PMID:12359715) RGD PMID:12359715 NCBI chr13:45,134,825...45,145,381
Ensembl chr13:45,134,834...45,145,381
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:894972|PMID:9252121)
UniProt
RGD
PMID:9252121 GO_REF:0000024 MGI:894972 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 acts_upstream_of_or_within ISO (MGI:1933463|PMID:11139578)
(MGI:2135469|PMID:11381262)
RGD PMID:11139578 PMID:11381262 MGI:1933463 MGI:2135469 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mir218-2 microRNA 218-2 involved_in ISO (PMID:21385766) RGD PMID:21385766 NCBI chr10:20,068,451...20,068,560
Ensembl chr10:20,068,451...20,068,560
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:1857478|MGI:2176055|MGI:2176057|MGI:96159|MGI:96677|MGI:96974 (MGI:1351242|PMID:10620616), (MGI:1932841|PMID:11297510), (MGI:3610917|PMID:12409258)
GO_REF:0000107
HGNC-UCL
RGD
Ensembl
PMID:10620616 PMID:11297510 PMID:12409258 GO_REF:0000024 GO_REF:0000107 MGI:1351242 MGI:1932841 MGI:3610917 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Nup62 nucleoporin 62 involved_in ISO (MGI:3526674|PMID:11489947) RGD PMID:11489947 MGI:3526674 NCBI chr 1:95,298,995...95,314,902
Ensembl chr 1:95,295,526...95,315,174
JBrowse link
G Paqr3 progestin and adipoQ receptor family member 3 acts_upstream_of_or_within ISO MGI:3757569 (MGI:3722998|PMID:17724343)
(PMID:17724343)
RGD PMID:17724343 MGI:3722998 NCBI chr14:12,462,568...12,484,999
Ensembl chr14:12,462,563...12,479,994
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in IEA
ISO
GO_REF:0000107
(MGI:6444553|PMID:30496354)
Ensembl
RGD
PMID:30496354 GO_REF:0000107 MGI:6444553 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within ISO (PMID:18382765) RGD PMID:18382765 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkcd protein kinase C, delta involved_in ISO (PMID:19279008) RGD PMID:19279008 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (PMID:22045810) RGD PMID:22045810 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 IDA RGD PMID:9857190 RGD:10044039 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856074 (MGI:1095647|PMID:9254656), (MGI:82729|PMID:9064344)
Ensembl
RGD
PMID:9064344 PMID:9254656 GO_REF:0000107 MGI:1095647 MGI:82729 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO
IBA
(PMID:19494114)
(MGI:4942250|PMID:12833140)
PMID:21873635
RGD PMID:12833140 PMID:19494114 PMID:21873635 MGI:4942250, RGD:13792537 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Rgs14 regulator of G-protein signaling 14 involved_in ISS
ISO
GO_REF:0000024
(MGI:4834960|PMID:20837545)
UniProt
RGD
PMID:20837545 GO_REF:0000024 MGI:4834960 NCBI chr17:9,248,982...9,263,104
Ensembl chr17:9,249,019...9,263,104
JBrowse link
G Rgs2 regulator of G-protein signaling 2 involved_in ISO (MGI:3836877|PMID:19127022) RGD PMID:19127022 MGI:3836877 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in IEA
ISO
GO_REF:0000107
(MGI:3510267|PMID:15337790)
Ensembl
RGD
PMID:15337790 GO_REF:0000107 MGI:3510267 NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 involved_in ISO (PMID:19279008) RGD PMID:19279008 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:3801250|PMID:18362153) RGD PMID:18362153 MGI:3801250 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3614383|PMID:16339969)
RGD PMID:16339969 PMID:21873635 MGI:3614383, RGD:13792537 NCBI chr 2:120,557,276...120,561,918
Ensembl chr 2:120,556,706...120,566,189
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3614383|PMID:16339969)
RGD PMID:16339969 PMID:21873635 MGI:3614383, RGD:13792537 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Spry3 sprouty RTK signaling antagonist 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:16,663,188...16,673,124
Ensembl chr12:16,663,389...16,672,531
JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3614383|PMID:16339969)
RGD PMID:16339969 PMID:21873635 MGI:3614383, RGD:13792537 NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004
JBrowse link
G Stk38 serine/threonine kinase 38 involved_in ISO (PMID:17906693) RGD PMID:17906693 NCBI chr20:7,034,245...7,067,803
Ensembl chr20:7,034,242...7,068,198
JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:14612383 RGD:1580517 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 involved_in ISO (PMID:19477270) RGD PMID:19477270 NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated acts_upstream_of_or_within ISO (MGI:3799599|PMID:17681137)
(PMID:17681137)
RGD PMID:17681137 MGI:3799599 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISO
ISS
(PMID:24512202)
GO_REF:0000024
RGD
UniProt
PMID:24512202 GO_REF:0000024 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:10391943)
MGI:3052343 (MGI:3051749|PMID:15306813)
PMID:21873635
RGD PMID:10391943 PMID:15306813 PMID:21873635 MGI:3051749, RGD:13792537 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp16 dual specificity phosphatase 16 involved_in ISO (PMID:11489891) RGD PMID:11489891 NCBI chr 4:167,546,780...167,629,949
Ensembl chr 4:167,548,155...167,629,980
JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3721484|PMID:12646564), (MGI:5009198|PMID:10945608), (MGI:5009411|PMID:16023107)
(PMID:16636664)
BHF-UCL
RGD
PMID:10945608 PMID:12646564 PMID:16023107 PMID:16636664 GO_REF:0000024 MGI:3721484 MGI:5009198 MGI:5009411 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 involved_in ISO (MGI:1913166|PMID:11034606) RGD PMID:11034606 MGI:1913166 NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in IMP PMID:21076496 RGD
UniProt
PMID:12064607 PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Serpinb3 serpin family B member 3 involved_in ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:23,274,120...23,280,082
Ensembl chr13:23,274,484...23,313,682
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108078|MGI:1860298 (MGI:3839161|PMID:19300477)
Ensembl
RGD
PMID:19300477 GO_REF:0000107 MGI:3839161 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:1860298|MGI:892014 (MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:3839161 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 acts_upstream_of_or_within ISO MGI:108078|MGI:892014 (MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:3839161 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224
JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO (MGI:3574697|PMID:15483136) RGD PMID:15483136 MGI:3574697 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      signal transduction 7133
        intracellular signal transduction 2748
          MAPK cascade 859
            negative regulation of MAPK cascade 205
              negative regulation of MAP kinase activity 66
                negative regulation of JUN kinase activity 16
Path 2
Term Annotations click to browse term
  biological_process 20091
    biological regulation 13996
      regulation of biological process 13218
        regulation of metabolic process 7044
          regulation of cellular metabolic process 5719
            regulation of phosphorus metabolic process 1521
              regulation of phosphate metabolic process 1520
                regulation of phosphorylation 1353
                  regulation of protein phosphorylation 1201
                    regulation of protein kinase activity 693
                      regulation of protein serine/threonine kinase activity 400
                        regulation of MAP kinase activity 209
                          negative regulation of MAP kinase activity 66
                            negative regulation of JUN kinase activity 16
paths to the root