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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043372 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: positive regulation of CD4-positive T lymphocyte differentiation;   positive regulation of CD4-positive T-cell differentiation;   positive regulation of CD4-positive, alpha beta T lymphocyte differentiation;   up regulation of CD4-positive, alpha beta T cell differentiation;   upregulation of CD4-positive, alpha beta T cell differentiation
 narrow_synonym: activation of CD4-positive, alpha beta T cell differentiation;   stimulation of CD4-positive, alpha beta T cell differentiation
 related_synonym: positive regulation of CD4-positive, alpha beta T cell development


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positive regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd83 CD83 molecule acts_upstream_of_or_within ISO MGI:3055293 (PMID:15322158) RGD PMID:15322158 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:17028180) RGD PMID:17028180 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO		 GO_REF:0000024
(MGI:3818191|PMID:19015308)		 UniProt
RGD		 PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G Sash3 SAM and SH3 domain containing 3 acts_upstream_of_or_within ISO MGI:3716944 (PMID:16227612) RGD PMID:16227612 NCBI chr  X:127,326,815...127,341,521
Ensembl chr  X:127,326,859...127,341,519 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:6140589|PMID:24880459)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24880459 GO_REF:0000024 GO_REF:0000107 MGI:6140589 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4819294|PMID:20639485) RGD PMID:20639485 MGI:4819294 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:6140589|PMID:24880459) RGD PMID:24880459 MGI:6140589 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034|MGI:2654936|MGI:3696705 (PMID:12612578), (PMID:16275384), (PMID:16301745), (PMID:18573908) RGD PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455 (PMID:16227984) RGD PMID:16227984 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Klhl25 kelch-like family member 25 involved_in ISO
ISS		 (PMID:34491895)
(MGI:6765767|PMID:34491895)
GO_REF:0000024		 RGD
UniProt		 PMID:34491895 GO_REF:0000024 MGI:6765767 NCBI chr 1:129,724,894...129,750,142
Ensembl chr 1:129,722,026...129,750,227 		JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
positive regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:17008549)
GO_REF:0000107
GO_REF:0000118		 UniProt
RGD
Ensembl
TreeGrafter		 PMID:17008549 GO_REF:0000024 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (MGI:3576832|PMID:15845453) RGD PMID:15845453 MGI:3576832 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (PMID:16424184) RGD PMID:16424184 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070 (PMID:11894097) RGD PMID:11894097 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
positive regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Malt1 MALT1 paracaspase involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Mir326 microRNA 326 acts_upstream_of_or_within ISO (PMID:19838199) RGD PMID:19838199 NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) RGD PMID:25282160 MGI:6142401 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:28262505)
(MGI:6106706|PMID:28262505)		 UniProt
RGD		 PMID:28262505 GO_REF:0000024 MGI:6106706 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) RGD PMID:28262505 MGI:6106706 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) RGD PMID:28262505 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO
IBA		 (MGI:3851279|PMID:19501566)
GO_REF:0000033		 RGD
GO_Central		 PMID:19501566 GO_REF:0000033 MGI:3851279 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3608083|PMID:12829194)		 Ensembl
RGD		 PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (PMID:16424184) RGD PMID:16424184 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) RGD PMID:12594267 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO		 GO_REF:0000024
(MGI:3584076|PMID:15987782)		 UniProt
RGD		 PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:4943387 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
positive regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO MGI:3721903 (PMID:24645804) RGD PMID:24645804 NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    immune system process 2982
      leukocyte activation 1048
        lymphocyte activation 847
          T cell activation 595
            alpha-beta T cell activation 199
              CD4-positive, alpha-beta T cell activation 133
                CD4-positive, alpha-beta T cell differentiation 102
                  positive regulation of CD4-positive, alpha-beta T cell differentiation 34
                    positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
                    positive regulation of T-helper cell differentiation + 21
Path 2
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      cellular developmental process 4747
        cell differentiation 4746
          cell development 3304
            hemopoiesis 1062
              leukocyte differentiation 674
                mononuclear cell differentiation 543
                  lymphocyte differentiation 447
                    T cell differentiation 323
                      alpha-beta T cell differentiation 140
                        CD4-positive, alpha-beta T cell differentiation 102
                          regulation of CD4-positive, alpha-beta T cell differentiation 59
                            positive regulation of CD4-positive, alpha-beta T cell differentiation 34
                              positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 8
                              positive regulation of T-helper cell differentiation + 21
paths to the root