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ONTOLOGY REPORT - ANNOTATIONS

Term:positive T cell selection
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Accession:GO:0043368 term browser browse the term
Definition:The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms:exact_synonym: positive T lymphocyte selection


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positive T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b B cell leukemia/lymphoma 11B acts_upstream_of_or_within IMP (PMID:17998389) MGI PMID:17998389 NCBI chr12:107,876,662...107,970,404
Ensembl chr12:107,876,662...107,969,861 		JBrowse link
G Braf Braf transforming gene acts_upstream_of_or_within IMP (PMID:23334952) MGI PMID:23334952 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Themis thymocyte selection associated involved_in IMP (MGI:4352756|PMID:19597499), (MGI:4352757|PMID:19597498), (MGI:4352758|PMID:19597497), (MGI:4361774|PMID:19805304) UniProt PMID:19597497 PMID:19597498 PMID:19597499 PMID:19805304 MGI:4352756 MGI:4352757 MGI:4352758 MGI:4361774 NCBI chr10:28,544,356...28,759,816
Ensembl chr10:28,544,356...28,759,814 		JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf Braf transforming gene acts_upstream_of_or_within IMP (PMID:18228248) MGI PMID:18228248 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within IMP (PMID:16501569) MGI PMID:16501569 NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573 		JBrowse link
G Shh sonic hedgehog involved_in IMP
ISO		 (MGI:3834308|PMID:17227833) BHF-UCL
MGI		 PMID:17227833 GO_REF:0000119 MGI:3834308 MGI:4834177 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsl cathepsin L involved_in IMP (MGI:2655909|PMID:9545226) UniProt PMID:9545226 MGI:2655909 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in IMP (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in TAS (MGI:3795336|PMID:18368049) UniProt PMID:18368049 MGI:3795336 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in TAS (MGI:3795336|PMID:18368049) UniProt PMID:18368049 MGI:3795336 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in IMP (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557 		JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 acts_upstream_of_or_within IMP (PMID:8170972) MGI PMID:8170972 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in IMP (MGI:2159528|PMID:11850626), (MGI:3045816|PMID:15078895) UniProt PMID:11850626 PMID:15078895 MGI:2159528 MGI:3045816 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IMP (MGI:5320871|PMID:22080863) UniProt PMID:22080863 MGI:5320871 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in IMP
ISO		 (MGI:5825383|PMID:28065600) UniProt
MGI		 PMID:28065600 GO_REF:0000119 MGI:4834177 MGI:5825383 NCBI chr 6:83,011,186...83,029,547
Ensembl chr 6:83,011,154...83,029,543 		JBrowse link
G Tbx21 T-box 21 involved_in IMP (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 involved_in IMP (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 1:161,322,221...161,333,903
Ensembl chr 1:161,322,224...161,332,859 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in IDA
ISO		 (MGI:6106706|PMID:28262505) UniProt
MGI		 PMID:28262505 GO_REF:0000119 MGI:4834177 MGI:6106706 NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608 		JBrowse link
G Brd4 bromodomain containing 4 involved_in IMP (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chr17:32,415,246...32,503,717
Ensembl chr17:32,415,248...32,503,696 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 involved_in IDA
IBA		 (MGI:3851279|PMID:19501566) BHF-UCL
GO_Central		 PMID:19501566 GO_REF:0000033 MGI:3851279 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen acts_upstream_of_or_within IMP (PMID:9133426) MGI PMID:9133426 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd3d CD3 antigen, delta polypeptide involved_in IMP
IBA		 (MGI:87267|PMID:9135151) UniProt
GO_Central		 PMID:9135151 GO_REF:0000033 MGI:87267 NCBI chr 9:44,893,067...44,898,350
Ensembl chr 9:44,893,084...44,898,637 		JBrowse link
G Cd3e CD3 antigen, epsilon polypeptide involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:44,910,033...44,920,961
Ensembl chr 9:44,910,038...44,920,925 		JBrowse link
G Cd3g CD3 antigen, gamma polypeptide involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:44,880,870...44,891,729
Ensembl chr 9:44,880,870...44,891,729 		JBrowse link
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) acts_upstream_of_or_within IMP (PMID:7679955), (PMID:8598040)
(PMID:9432982)		 MGI PMID:7679955 PMID:8598040 PMID:9432982 NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724 		JBrowse link
G Dock2 dedicator of cyto-kinesis 2 acts_upstream_of_or_within IMP (PMID:12871644) MGI PMID:12871644 NCBI chr11:34,176,815...34,674,732
Ensembl chr11:34,176,815...34,674,719 		JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa acts_upstream_of_or_within IMP (PMID:8598040)
(PMID:8598041), (PMID:9432982)
(PMID:8638109)		 MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075 		JBrowse link
G Itpkb inositol 1,4,5-trisphosphate 3-kinase B acts_upstream_of_or_within IMP (PMID:15064401) MGI PMID:15064401 NCBI chr 1:180,156,655...180,252,367
Ensembl chr 1:180,158,050...180,252,367 		JBrowse link
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 involved_in IMP (MGI:3820023|PMID:17579027) UniProt PMID:17579027 MGI:3820023 NCBI chr 8:106,785,450...106,857,169
Ensembl chr 8:106,785,472...106,857,169 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within IMP (PMID:8666928) MGI PMID:8666928 NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446 		JBrowse link
G Shh sonic hedgehog involved_in IMP (MGI:3834308|PMID:17227833) BHF-UCL PMID:17227833 MGI:3834308 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254 		JBrowse link
G Skint1 selection and upkeep of intraepithelial T cells 1 acts_upstream_of_or_within IDA
IMP		 (PMID:21300860)
(PMID:18408721)		 MGI PMID:18408721 PMID:21300860 NCBI chr 4:111,863,466...111,886,735
Ensembl chr 4:111,863,466...111,886,735 		JBrowse link
G Srf serum response factor acts_upstream_of_or_within IMP (PMID:21098124) MGI PMID:21098124 NCBI chr17:46,857,764...46,869,194
Ensembl chr17:46,859,255...46,867,101 		JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within IMP (PMID:21487392) MGI PMID:21487392 NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase acts_upstream_of_or_within ISO
IMP		 (PMID:7630421) MGI PMID:7630421 GO_REF:0000008 NCBI chr 1:36,800,912...36,821,899
Ensembl chr 1:36,800,879...36,821,899 		JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in IMP (MGI:5554515|PMID:24184560) UniProt PMID:24184560 MGI:5554515 NCBI chr11:78,248,403...78,277,597
Ensembl chr11:78,248,403...78,277,384 		JBrowse link
G Tox thymocyte selection-associated high mobility group box involved_in IMP (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chr 4:6,686,353...6,991,557
Ensembl chr 4:6,686,353...6,991,557 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within IGI (PMID:20706986) MGI PMID:20706986 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in IMP (PMID:26410627) MGI PMID:26410627 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Spn sialophorin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:126,731,404...126,743,785
Ensembl chr 7:126,731,404...126,736,995 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within IGI (PMID:20706986) MGI PMID:20706986 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G Tbx21 T-box 21 involved_in IDA (MGI:1354779|PMID:10761931) UniProt PMID:10761931 MGI:1354779 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper transcription factor, ATF-like involved_in IMP (MGI:3851267|PMID:19578362), (MGI:5448096|PMID:22983707) UniProt PMID:19578362 PMID:22983707 MGI:3851267 MGI:5448096 NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861 		JBrowse link
G Il6 interleukin 6 involved_in IDA
IMP		 (MGI:6142555|PMID:27893700)
(MGI:3692468|PMID:16990136)		 UniProt PMID:16990136 PMID:27893700 MGI:3692468 MGI:6142555 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha involved_in IDA (MGI:6142555|PMID:27893700) UniProt PMID:27893700 MGI:6142555 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in IMP (MGI:5448096|PMID:22983707) UniProt PMID:22983707 MGI:5448096 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Ly9 lymphocyte antigen 9 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:171,416,172...171,434,917
Ensembl chr 1:171,416,192...171,434,978 		JBrowse link
G Otud5 OTU domain containing 5 acts_upstream_of_or_within IMP (PMID:25470037) MGI PMID:25470037 NCBI chr  X:7,705,852...7,742,861
Ensembl chr  X:7,707,603...7,742,865 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:171,745,002...171,776,525
Ensembl chr 1:171,745,082...171,780,737 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in IMP (MGI:5825383|PMID:28065600) UniProt PMID:28065600 MGI:5825383 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in TAS (MGI:3795336|PMID:18368049) UniProt PMID:18368049 MGI:3795336 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    immune system process 3142
      T cell selection 61
        positive T cell selection 45
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 27
          positive extrathymic T cell selection 0
          positive thymic T cell selection + 18
Path 2
Term Annotations click to browse term
  biological_process 28573
    developmental process 7369
      cellular developmental process 5063
        cell differentiation 5062
          cell development 3447
            hemopoiesis 1161
              leukocyte differentiation 751
                mononuclear cell differentiation 607
                  lymphocyte differentiation 503
                    T cell differentiation 357
                      T cell selection 61
                        positive T cell selection 45
                          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 27
                          positive extrathymic T cell selection 0
                          positive thymic T cell selection + 18
paths to the root