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ONTOLOGY REPORT - ANNOTATIONS

Term:natural killer cell degranulation
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Accession:GO:0043320 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.
Synonyms:exact_synonym: NK cell degranulation;   NK cell granule exocytosis;   natural killer cell granule exocytosis


show annotations for term's descendants           Sort by:
natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CORO1A coronin 1A involved_in IMP (PMID:24760828) UniProt PMID:24760828 NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076 		JBrowse link
G FCGR3A Fc gamma receptor IIIa involved_in IDA (PMID:25786175), (PMID:28652325) UniProt PMID:25786175 PMID:28652325 NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968 		JBrowse link
G KLRF2 killer cell lectin like receptor F2 involved_in TAS (PMID:20194751) UniProt PMID:20194751 NCBI chr12:9,881,489...9,895,833
Ensembl chr12:9,881,489...9,895,833 		JBrowse link
G NKG7 natural killer cell granule protein 7 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:51,371,620...51,372,654
Ensembl chr19:51,371,606...51,372,701 		JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11266473) Ensembl
MGI		 PMID:11266473 GO_REF:0000107 NCBI chr15:55,202,966...55,289,813
Ensembl chr15:55,202,966...55,319,113 		JBrowse link
G STX11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chr 6:144,139,963...144,191,939
Ensembl chr 6:144,150,487...144,191,939 		JBrowse link
G UNC13D unc-13 homolog D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17420270) Ensembl
MGI		 PMID:17420270 GO_REF:0000107 NCBI chr17:75,827,225...75,844,404
Ensembl chr17:75,827,225...75,844,785 		JBrowse link
G VAMP2 vesicle associated membrane protein 2 NOT|involved_in IMP (PMID:18042464) UniProt PMID:18042464 NCBI chr17:8,159,147...8,162,948
Ensembl chr17:8,159,149...8,163,546 		JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in IMP (PMID:18042464) UniProt PMID:18042464 NCBI chr  X:155,881,345...155,943,769
NCBI chr  Y:57,067,865...57,130,289
Ensembl chr  Y:57,067,865...57,130,289
Ensembl chr  X:57,067,865...57,130,289 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HLA-F major histocompatibility complex, class I, F involved_in IDA (PMID:24018270) UniProt PMID:24018270 NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528 		JBrowse link
G LGALS9 galectin 9 involved_in ISO (MGI:5491117|PMID:23408620) UniProt PMID:23408620 MGI:5491117 NCBI chr17:27,631,188...27,649,560
Ensembl chr17:27,629,798...27,649,560 		JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IMP (PMID:23632890) UniProt PMID:23632890 NCBI chr16:71,729,000...71,808,834
Ensembl chr16:71,729,000...71,809,201 		JBrowse link
G CD160 CD160 molecule involved_in IDA (PMID:19109136) UniProt PMID:19109136 NCBI chr 1:145,719,499...145,739,288
Ensembl chr 1:145,719,471...145,739,288 		JBrowse link
G HLA-F major histocompatibility complex, class I, F involved_in IDA (PMID:27455421) UniProt PMID:27455421 NCBI chr 6:29,723,434...29,738,532
Ensembl chr 6:29,722,775...29,738,528 		JBrowse link
G KLRC2 killer cell lectin like receptor C2 involved_in IDA (PMID:21825173) UniProt PMID:21825173 NCBI chr12:10,430,599...10,436,010
Ensembl chr12:10,426,854...10,442,300 		JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IMP (PMID:23632890) UniProt PMID:23632890 NCBI chr13:113,297,239...113,323,672
Ensembl chr13:113,297,239...113,323,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    immune system process 3226
      immune effector process 824
        leukocyte degranulation 99
          natural killer cell degranulation 15
            negative regulation of natural killer cell degranulation 2
            positive regulation of natural killer cell degranulation 5
            regulation of natural killer cell degranulation + 6
Path 2
Term Annotations click to browse term
  biological_process 19669
    response to stimulus 10176
      response to external stimulus 2939
        response to external biotic stimulus 1966
          response to other organism 1963
            defense response to other organism 1393
              defense response to symbiont 1277
                innate immune response 1084
                  natural killer cell mediated immunity 92
                    natural killer cell mediated cytotoxicity 88
                      natural killer cell degranulation 15
                        negative regulation of natural killer cell degranulation 2
                        positive regulation of natural killer cell degranulation 5
                        regulation of natural killer cell degranulation + 6
paths to the root