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ONTOLOGY REPORT - ANNOTATIONS

Term:cytotoxic T cell degranulation
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Accession:GO:0043316 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.
Synonyms:exact_synonym: cytotoxic T cell granule exocytosis;   cytotoxic T lymphocyte degranulation;   cytotoxic T lymphocyte granule exocytosis


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cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB27A RAB27A, member RAS oncogene family involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11266473) Ensembl
MGI		 PMID:11266473 GO_REF:0000107 NCBI chr15:34,174,491...34,263,045
Ensembl chr15:52,498,202...52,529,984 		JBrowse link
G STX11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080), (PMID:23190531) MGI PMID:23042080 PMID:23190531 NCBI chr 6:141,924,656...141,974,579
Ensembl chr 6:146,688,670...146,689,533 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (PMID:18424730) UniProt PMID:18424730 NCBI chr19:39,395,550...39,417,063
Ensembl chr19:47,989,430...48,008,739 		JBrowse link
G NCKAP1L NCK associated protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:34,200,102...34,249,873
Ensembl chr12:34,932,470...34,977,881 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    immune system process 2406
      immune effector process 644
        leukocyte degranulation 86
          cytotoxic T cell degranulation 4
            negative regulation of cytotoxic T cell degranulation 2
            positive regulation of cytotoxic T cell degranulation 0
            regulation of cytotoxic T cell degranulation + 2
Path 2
Term Annotations click to browse term
  biological_process 16440
    localization 5279
      establishment of localization 4578
        transport 4266
          export from cell 1022
            secretion by cell 953
              exocytosis 370
                regulated exocytosis 255
                  leukocyte degranulation 86
                    cytotoxic T cell degranulation 4
                      negative regulation of cytotoxic T cell degranulation 2
                      positive regulation of cytotoxic T cell degranulation 0
                      regulation of cytotoxic T cell degranulation + 2
paths to the root