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ONTOLOGY REPORT - ANNOTATIONS

Term:neutrophil degranulation
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Accession:GO:0043312 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
Synonyms:exact_synonym: neutrophil granule exocytosis
 related_synonym: heterophil degranulation

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neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase acts_upstream_of ISO (PMID:19703997) MGI PMID:19703997 NCBI chrNW_004955481:2,503,309...2,710,667
Ensembl chrNW_004955481:2,503,315...2,654,244 		JBrowse link
G Anxa3 annexin A3 involved_in ISO (PMID:9550422) UniProt PMID:9550422 NCBI chrNW_004955433:2,981,113...3,043,894
Ensembl chrNW_004955433:2,977,513...3,044,446 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of ISO (PMID:19703997) MGI PMID:19703997 NCBI chrNW_004955455:7,598,794...7,727,386
Ensembl chrNW_004955455:7,598,794...7,727,386 		JBrowse link
G Myo1f myosin IF acts_upstream_of_or_within ISO (PMID:17023661) MGI PMID:17023661 NCBI chrNW_004955563:880,545...916,630
Ensembl chrNW_004955563:880,545...916,630 		JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing NOT|involved_in ISO (MGI:6103777|PMID:28779020) UniProt PMID:28779020 MGI:6103777 NCBI chrNW_004955457:6,749,226...6,841,855
Ensembl chrNW_004955457:6,748,534...6,842,489 		JBrowse link
G Stx11 syntaxin 11 acts_upstream_of_or_within ISO (PMID:23042080) MGI PMID:23042080 NCBI chrNW_004955436:16,303,169...16,327,854
Ensembl chrNW_004955436:16,303,189...16,327,854 		JBrowse link
G Stxbp2 syntaxin binding protein 2 involved_in ISO (PMID:18588921) UniProt PMID:18588921 NCBI chrNW_004955563:1,617,621...1,624,441
Ensembl chrNW_004955563:1,617,621...1,624,441 		JBrowse link
G Stxbp3 syntaxin binding protein 3 involved_in ISO (PMID:18588921) UniProt PMID:18588921 NCBI chrNW_004955435:12,215,665...12,270,769
Ensembl chrNW_004955435:12,215,665...12,274,465 		JBrowse link
G Vamp2 vesicle associated membrane protein 2 NOT|involved_in ISO (PMID:16677249) UniProt PMID:16677249 NCBI chrNW_004955467:8,793,296...8,796,771
Ensembl chrNW_004955467:8,793,296...8,796,771 		JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO (PMID:16677249)
PMID:14993220		 UniProt PMID:14993220 PMID:16677249 RGD:8553828 NCBI chrNW_004955594:20,496...72,648
Ensembl chrNW_004955594:18,727...72,654 		JBrowse link
G Vamp8 vesicle associated membrane protein 8 NOT|involved_in ISO (PMID:16677249) UniProt PMID:16677249 NCBI chrNW_004955424:1,922,830...1,926,844
Ensembl chrNW_004955424:1,923,092...1,926,728 		JBrowse link
negative regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO (PMID:19703997) MGI PMID:19703997 NCBI chrNW_004955481:2,503,309...2,710,667
Ensembl chrNW_004955481:2,503,315...2,654,244 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO (PMID:19703997) MGI PMID:19703997 NCBI chrNW_004955455:7,598,794...7,727,386
Ensembl chrNW_004955455:7,598,794...7,727,386 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO (MGI:6381024|PMID:30911105) ARUK-UCL PMID:30911105 MGI:6381024 NCBI chrNW_004955422:873,735...886,560
Ensembl chrNW_004955422:873,735...886,560 		JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004955555:1,106,722...1,120,756 JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201 		JBrowse link
G Ptafr platelet activating factor receptor ISO RGD PMID:2829894 RGD:10041060 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929 		JBrowse link
regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pram1 PML-RARA regulated adaptor molecule 1 acts_upstream_of_or_within ISO (PMID:15572693) MGI PMID:15572693 NCBI chrNW_004955563:924,365...933,198
Ensembl chrNW_004955563:926,765...933,183 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in ISO (MGI:4414596|PMID:19797524) UniProt PMID:19797524 MGI:4414596 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12321
    immune system process 1969
      immune effector process 530
        leukocyte degranulation 78
          neutrophil degranulation 18
            negative regulation of neutrophil degranulation 3
            positive regulation of neutrophil degranulation 4
            regulation of neutrophil degranulation + 9
Path 2
Term Annotations click to browse term
  biological_process 12321
    localization 4252
      establishment of localization 3589
        transport 3317
          secretion 996
            secretion by cell 858
              exocytosis 312
                regulated exocytosis 233
                  leukocyte degranulation 78
                    neutrophil degranulation 18
                      negative regulation of neutrophil degranulation 3
                      positive regulation of neutrophil degranulation 4
                      regulation of neutrophil degranulation + 9
paths to the root