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ONTOLOGY REPORT - ANNOTATIONS


Term:mast cell degranulation
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Accession:GO:0043303 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
Synonyms:exact_synonym: mast cell granule exocytosis



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mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor acts_upstream_of
involved_in
ISO
IEA
(MGI:3776334|PMID:11454903)
GO_REF:0000107
RGD
Ensembl
PMID:11454903 GO_REF:0000107 MGI:3776334 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
JBrowse link
G Cbl Cbl proto-oncogene IEP RGD PMID:18243321 RGD:11576314 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Cd300a Cd300a molecule acts_upstream_of ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Chga chromogranin A involved_in ISS
ISO
GO_REF:0000024
(PMID:21214543)
UniProt
RGD
PMID:21214543 GO_REF:0000024 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Clnk cytokine-dependent hematopoietic cell linker involved_in ISO (MGI:2179131|PMID:10744659) RGD PMID:10744659 MGI:2179131 NCBI chr14:71,923,894...72,101,180
Ensembl chr14:71,873,105...72,101,208
JBrowse link
G Cplx2 complexin 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:10,219,577...10,292,835
Ensembl chr17:10,222,347...10,293,855
JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Gpr15lg G protein-coupled receptor 15 ligand involved_in ISO
ISS
(PMID:35704588)
GO_REF:0000024
RGD
UniProt
PMID:35704588 GO_REF:0000024 NCBI chr16:12,868,270...12,875,876
Ensembl chr16:12,868,270...12,875,876
JBrowse link
G Grp gastrin releasing peptide involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:6872268|PMID:21933692)
(PMID:21933692)
UniProt
RGD
PMID:21933692 GO_REF:0000024 MGI:6872268 NCBI chr18:59,388,679...59,402,061
Ensembl chr18:59,388,274...59,402,061
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase involved_in ISO (PMID:20100931) RGD PMID:20100931 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lat linker for activation of T cells involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
JBrowse link
G Lat2 linker for activation of T cells family, member 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr12:22,104,163...22,118,294
Ensembl chr12:22,104,219...22,118,288
JBrowse link
G Milr1 mast cell immunoglobulin-like receptor 1 involved_in IEA
ISO
ISS
GO_REF:0000002
(MGI:4461821|PMID:20526344)
GO_REF:0000024
InterPro
RGD
UniProt
PMID:20526344 GO_REF:0000002 GO_REF:0000024 MGI:4461821 NCBI chr10:91,684,288...91,705,284
Ensembl chr10:91,687,831...91,705,282
JBrowse link
G Mrgprx2 MAS related GPR family member X2 involved_in ISO (PMID:22069323) RGD PMID:22069323 NCBI chr 1:98,116,192...98,135,534 JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:5586645|PMID:24586680)
UniProt
RGD
PMID:24586680 GO_REF:0000024 MGI:5586645 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Pla2g3 phospholipase A2, group III acts_upstream_of_or_within ISO MGI:4461174 (MGI:5492190|PMID:23624557) RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Ptgdrl1 prostaglandin D2 receptor-like 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:18,074,153...18,081,335
Ensembl chr15:18,072,361...18,081,437
JBrowse link
G Ptgds prostaglandin D2 synthase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Rab44 RAB44, member RAS oncogene family acts_upstream_of_or_within ISO MGI:6695900 (MGI:6693988|PMID:32238914) RGD PMID:32238914 MGI:6693988 NCBI chr20:7,164,576...7,198,473
Ensembl chr20:7,164,720...7,198,468
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 acts_upstream_of_or_within ISO MGI:2386261 (MGI:3758152|PMID:17190838) RGD PMID:17190838 MGI:3758152 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of
involved_in
ISO
IEA
MGI:2384078 (MGI:85068|PMID:9000133)
GO_REF:0000107
RGD
Ensembl
PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
G Tac4 tachykinin precursor 4 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:80,207,824...80,216,156
Ensembl chr10:80,207,610...80,216,156
JBrowse link
histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07053516.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:12220673 RGD:1600535 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IMP RGD PMID:16177098 RGD:1578516 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Rab44 RAB44, member RAS oncogene family acts_upstream_of_or_within ISO MGI:6695900 (MGI:6693988|PMID:32238914) RGD PMID:32238914 MGI:6693988 NCBI chr20:7,164,576...7,198,473
Ensembl chr20:7,164,720...7,198,468
JBrowse link
G Snap23 synaptosome associated protein 23 involved_in ISO
IEA
(PMID:18253931)
GO_REF:0000107
RGD
Ensembl
PMID:18253931 GO_REF:0000107 NCBI chr 3:107,514,088...107,546,177
Ensembl chr 3:107,514,131...107,544,320
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta IMP RGD PMID:12499633 RGD:1625716 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in
acts_upstream_of_or_within
ISO (PMID:16339535)
(MGI:3721168|PMID:12874256)
RGD PMID:12874256 PMID:16339535 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Cd84 CD84 molecule involved_in ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076
JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO MGI:2179135 (MGI:4367570|PMID:18421012) RGD PMID:18421012 MGI:4367570 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738
JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:2653910 (MGI:3589858|PMID:15944273)
GO_REF:0000107
RGD
Ensembl
PMID:15944273 GO_REF:0000107 MGI:3589858 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)
RGD PMID:23624557 MGI:5492190 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr12:16,728,477...16,764,261
Ensembl chr12:16,728,524...16,764,097
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 involved_in IEA
ISO
GO_REF:0000107
(PMID:18253931)
Ensembl
RGD
PMID:18253931 GO_REF:0000107 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3776334|PMID:11454903)
Ensembl
RGD
PMID:11454903 GO_REF:0000107 MGI:3776334 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:18209484 RGD:5130941 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of_or_within ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO
GO_REF:0000024
(MGI:5294498|PMID:21746961)
UniProt
RGD
PMID:21746961 GO_REF:0000024 MGI:5294498 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Gab2 GRB2-associated binding protein 2 involved_in ISO
ISS
(MGI:2137187|PMID:11449275)
GO_REF:0000024
RGD
UniProt
PMID:11449275 GO_REF:0000024 MGI:2137187 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gata1 GATA binding protein 1 IMP RGD PMID:22390417 RGD:9587812 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gata2 GATA binding protein 2 IMP RGD PMID:22390417 RGD:9587812 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO MGI:1931804|MGI:96556 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1857195|MGI:96541 (MGI:3589858|PMID:15944273)
RGD PMID:15944273 PMID:21873635 MGI:3589858, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:1861951 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IMP RGD PMID:16177098 RGD:1578516 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310
JBrowse link
G Nppc natriuretic peptide C involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:16861349 RGD:2299903 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) RGD PMID:17346996 MGI:3703830 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP RGD PMID:23487749 RGD:12904029 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:23487749 RGD:12904029 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
MGI:2384078 (MGI:85068|PMID:9000133)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:9000133 PMID:16861349 PMID:21873635 GO_REF:0000107 MGI:85068, RGD:2299903, RGD:13792537 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snx6 sorting nexin 6 NOT|involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT|involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr10:53,793,581...53,797,815
Ensembl chr10:53,793,923...53,797,809
JBrowse link
G Vamp3 vesicle-associated membrane protein 3 NOT|involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 5:161,498,109...161,508,704
Ensembl chr 5:161,498,109...161,508,751
JBrowse link
regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Fer FER tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451
JBrowse link
G Fes FES proto-oncogene, tyrosine kinase involved_in ISO
IBA
(PMID:19001085)
PMID:21873635
RGD PMID:19001085 PMID:21873635 RGD:13792537 NCBI chr 1:134,337,698...134,346,934
Ensembl chr 1:134,337,698...134,346,934
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(MGI:3703139|PMID:16272347)
UniProt
RGD
PMID:16272347 PMID:21873635 GO_REF:0000024 MGI:3703139, RGD:13792537 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 involved_in ISO (MGI:5298334|PMID:21063107) RGD PMID:21063107 MGI:5298334 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Rac2 Rac family small GTPase 2 involved_in ISO (MGI:3655336|PMID:10843388) RGD PMID:10843388 MGI:3655336 NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
JBrowse link
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed involved_in IBA
IDA
PMID:21873635
PMID:25122211
GO_Central
UniProt
PMID:21873635 PMID:25122211 RGD:13792537, RGD:10047193 NCBI chr 4:159,772,693...159,809,322
Ensembl chr 4:159,772,786...159,806,382
JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:12482918 RGD:2312429 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458
JBrowse link
G Unc13d unc-13 homolog D involved_in ISO
IEA
(PMID:15548590)
GO_REF:0000107
RGD
Ensembl
PMID:15548590 GO_REF:0000107 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687
JBrowse link
serotonin secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule acts_upstream_of_or_within ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    localization 5647
      establishment of localization 4974
        establishment of organelle localization 446
          mast cell degranulation 63
            histamine secretion by mast cell + 15
            negative regulation of mast cell degranulation 7
            positive regulation of mast cell degranulation + 24
            regulation of mast cell degranulation + 39
            serotonin secretion by mast cell 1
Path 2
Term Annotations click to browse term
  biological_process 20094
    localization 5647
      establishment of localization 4974
        transport 4811
          export from cell 1066
            secretion by cell 993
              exocytosis 430
                regulated exocytosis 305
                  leukocyte degranulation 95
                    mast cell degranulation 63
                      histamine secretion by mast cell + 15
                      negative regulation of mast cell degranulation 7
                      positive regulation of mast cell degranulation + 24
                      regulation of mast cell degranulation + 39
                      serotonin secretion by mast cell 1
paths to the root