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ONTOLOGY REPORT - ANNOTATIONS


Term:mast cell degranulation
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Accession:GO:0043303 term browser browse the term
Definition:The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
Synonyms:exact_synonym: mast cell granule exocytosis


show annotations for term's descendants           Sort by:
 
mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene IEP RGD PMID:18243321 RGD:11576314 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Chga chromogranin A IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21214543)
Ensembl
UniProt
RGD
PMID:21214543 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Clnk cytokine-dependent hematopoietic cell linker ISO (MGI:2179131|PMID:10744659) RGD PMID:10744659 MGI:2179131 NCBI chr14:76,657,165...76,834,050
Ensembl chr14:76,657,311...76,833,161
JBrowse link
G Cplx2 complexin 2 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase ISO (PMID:20100931) RGD PMID:20100931 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Lat linker for activation of T cells IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:197,765,644...197,770,669
Ensembl chr 1:197,765,644...197,770,669
JBrowse link
G Lat2 linker for activation of T cells family, member 2 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr12:25,114,099...25,128,381
Ensembl chr12:25,119,355...25,125,749
JBrowse link
G Milr1 mast cell immunoglobulin-like receptor 1 ISS
ISO
IEA
GO_REF:0000024
(MGI:4461821|PMID:20526344)
GO_REF:0000002
UniProt
RGD
InterPro
PMID:20526344 GO_REF:0000002, GO_REF:0000024, MGI:4461821 NCBI chr10:94,944,243...94,961,795
Ensembl chr10:94,944,436...94,961,791
JBrowse link
G Mrgprx2 MAS related GPR family member X2 ISO (PMID:22069323) RGD PMID:22069323 NCBI chr 1:103,743,746...103,760,945
Ensembl chr 1:103,741,503...103,760,913
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 ISS
ISO
GO_REF:0000024
(MGI:5586645|PMID:24586680)
UniProt
RGD
PMID:24586680 GO_REF:0000024, MGI:5586645 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Pla2g3 phospholipase A2, group III ISO MGI:4461174 (MGI:5492190|PMID:23624557) RGD PMID:23624557 MGI:5492190 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Ptgdrl prostaglandin D2 receptor-like IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:18,089,077...18,095,979
Ensembl chr15:18,088,897...18,096,039
JBrowse link
G Ptgds prostaglandin D2 synthase IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 ISO MGI:2386261 (MGI:3758152|PMID:17190838) RGD PMID:17190838 MGI:3758152 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Tac4 tachykinin precursor 4 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:83,081,168...83,089,487
Ensembl chr10:83,081,168...83,089,481
JBrowse link
histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07053516.1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr 3:112,346,627...112,361,216 JBrowse link
G Adora3 adenosine A3 receptor ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Btk Bruton tyrosine kinase IMP RGD PMID:12220673 RGD:1600535 NCBI chr  X:105,360,922...105,390,580
Ensembl chr  X:105,360,922...105,390,580
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IMP RGD PMID:16177098 RGD:1578516 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Snap23 synaptosome associated protein 23 ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 3:112,333,972...112,362,960 JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta IMP RGD PMID:12499633 RGD:1625716 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (PMID:16339535)
(MGI:3721168|PMID:12874256)
RGD PMID:12874256, PMID:16339535 MGI:3721168 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Cd84 CD84 molecule ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865
JBrowse link
G Foxf1 forkhead box F1 ISO MGI:2179135 (MGI:4367570|PMID:18421012) RGD PMID:18421012 MGI:4367570 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086
JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 IEA
ISO
GO_REF:0000107
MGI:2653910 (MGI:3589858|PMID:15944273)
Ensembl
RGD
PMID:15944273 GO_REF:0000107, MGI:3589858 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061
JBrowse link
G Lgals9 galectin 9 ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 ISO MGI:3051384 (MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:3050742 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959
JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Pla2g3 phospholipase A2, group III ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)
RGD PMID:23624557 MGI:5492190 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Snx4 sorting nexin 4 ISO (PMID:18253931) RGD PMID:18253931 NCBI chr11:70,693,381...70,753,620
Ensembl chr11:70,693,366...70,753,632
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 ISO (PMID:18253931) RGD PMID:18253931 NCBI chr12:18,996,566...19,033,714
Ensembl chr12:18,996,591...19,030,381
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 IEA
ISO
GO_REF:0000107
(PMID:18253931)
Ensembl
RGD
PMID:18253931 GO_REF:0000107 NCBI chr 4:100,250,301...100,252,756
Ensembl chr 4:100,250,301...100,252,755
JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor IEA
ISO
GO_REF:0000107
(MGI:3776334|PMID:11454903)
Ensembl
RGD
PMID:11454903 GO_REF:0000107, MGI:3776334 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Adora3 adenosine A3 receptor ISO MGI:2155986 (MGI:2664591|PMID:12817016) RGD PMID:12817016 MGI:2664591 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:18209484 RGD:5130941 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig ISO MGI:2384004 (MGI:3029067|PMID:14764707) RGD PMID:14764707 MGI:3029067 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISS
ISO
GO_REF:0000024
(MGI:5294498|PMID:21746961)
UniProt
RGD
PMID:21746961 GO_REF:0000024, MGI:5294498 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Gab2 GRB2-associated binding protein 2 ISS
ISO
GO_REF:0000024
(MGI:2137187|PMID:11449275)
UniProt
RGD
PMID:11449275 GO_REF:0000024, MGI:2137187 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Gata1 GATA binding protein 1 IMP RGD PMID:22390417 RGD:9587812 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066
JBrowse link
G Gata2 GATA binding protein 2 IMP RGD PMID:22390417 RGD:9587812 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
JBrowse link
G Il13 interleukin 13 ISO MGI:1931804|MGI:96556 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 IBA
ISO
PMID:21873635
MGI:1857195|MGI:96541 (MGI:3589858|PMID:15944273)
RGD PMID:15944273, PMID:21873635 MGI:3589858, RGD:13792537 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor ISO MGI:1861951 (MGI:3589858|PMID:15944273) RGD PMID:15944273 MGI:3589858 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IMP RGD PMID:16177098 RGD:1578516 NCBI chr 1:227,957,363...227,965,312
Ensembl chr 1:227,957,302...227,965,386
JBrowse link
G Nppc natriuretic peptide C IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:16861349 RGD:2299903 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Sphk2 sphingosine kinase 2 ISO (MGI:3703830|PMID:17346996) RGD PMID:17346996 MGI:3703830 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP RGD PMID:23487749 RGD:12904029 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:23487749 RGD:12904029 NCBI chr12:2,180,101...2,191,863
Ensembl chr12:2,180,150...2,191,175
JBrowse link
G Syk spleen associated tyrosine kinase IMP
ISO
IBA
IEA
MGI:2384078 (MGI:85068|PMID:9000133)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:9000133, PMID:16861349, PMID:21873635 GO_REF:0000107, MGI:85068, RGD:2299903, RGD:13792537 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snx6 sorting nexin 6 NOT ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 6:75,626,927...75,670,172
Ensembl chr 6:75,626,927...75,670,135
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 NOT ISO (PMID:18253931) RGD PMID:18253931 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link
G Vamp3 vesicle-associated membrane protein 3 NOT ISO (PMID:18253931) RGD PMID:18253931 NCBI chr 5:168,126,157...168,136,628
Ensembl chr 5:168,126,157...168,136,666
JBrowse link
regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Blk BLK proto-oncogene, Src family tyrosine kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Fer FER tyrosine kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:111,557,804...111,868,583
Ensembl chr 9:111,597,037...111,862,670
JBrowse link
G Fes FES proto-oncogene, tyrosine kinase ISO
IBA
(PMID:19001085)
PMID:21873635
RGD PMID:19001085, PMID:21873635 RGD:13792537 NCBI chr 1:142,174,648...142,183,884
Ensembl chr 1:142,174,648...142,183,884
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISS
ISO
IBA
GO_REF:0000024
(MGI:3703139|PMID:16272347)
PMID:21873635
UniProt
RGD
PMID:16272347, PMID:21873635 GO_REF:0000024, MGI:3703139, RGD:13792537 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO (MGI:5298334|PMID:21063107) RGD PMID:21063107 MGI:5298334 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Rac2 Rac family small GTPase 2 ISO (MGI:3655336|PMID:10843388) RGD PMID:10843388 MGI:3655336 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G RGD1311164 similar to DNA segment, Chr 6, Wayne State University 163, expressed IDA
IBA
PMID:25122211
PMID:21873635
UniProt
GO_Central
PMID:25122211, PMID:21873635 RGD:10047193, RGD:13792537 NCBI chr 4:159,483,089...159,518,387
Ensembl chr 4:159,483,131...159,515,447
JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:12482918 RGD:2312429 NCBI chr12:2,180,101...2,191,863
Ensembl chr12:2,180,150...2,191,175
JBrowse link
G Unc13d unc-13 homolog D IEA
ISO
GO_REF:0000107
(PMID:15548590)
Ensembl
RGD
PMID:15548590 GO_REF:0000107 NCBI chr10:104,613,907...104,628,664
Ensembl chr10:104,613,928...104,628,676
JBrowse link
serotonin secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (MGI:3721168|PMID:12874256) RGD PMID:12874256 MGI:3721168 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        establishment of organelle localization 415
          mast cell degranulation 60
            histamine secretion by mast cell + 14
            negative regulation of mast cell degranulation 7
            positive regulation of mast cell degranulation + 24
            regulation of mast cell degranulation + 39
            serotonin secretion by mast cell 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          export from cell 1006
            secretion by cell 955
              exocytosis 426
                regulated exocytosis 292
                  leukocyte degranulation 89
                    mast cell degranulation 60
                      histamine secretion by mast cell + 14
                      negative regulation of mast cell degranulation 7
                      positive regulation of mast cell degranulation + 24
                      regulation of mast cell degranulation + 39
                      serotonin secretion by mast cell 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.