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ONTOLOGY REPORT - ANNOTATIONS

Term:cytoplasmic SCF ubiquitin ligase complex
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Accession:GO:0043223 term browser browse the term
Definition:A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms:exact_synonym: cytoplasmic SCF complex;   cytoplasmic Skp1/Cul1/F-box protein complex;   cytoplasmic cullin complex


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  cellular_component 18700
    cellular anatomical entity 18479
      cytoplasm 10635
        cytoplasmic ubiquitin ligase complex 14
          cytoplasmic SCF ubiquitin ligase complex 0
Path 2
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  cellular_component 18700
    protein-containing complex 6005
      catalytic complex 1712
        transferase complex 838
          ubiquitin ligase complex 319
            cullin-RING ubiquitin ligase complex 186
              SCF ubiquitin ligase complex 68
                cytoplasmic SCF ubiquitin ligase complex 0
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