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ONTOLOGY REPORT - ANNOTATIONS


Term:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
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Accession:GO:0043162 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
Synonyms:exact_synonym: ubiquitin-dependent protein breakdown via the multivesicular body pathway;   ubiquitin-dependent protein catabolic process via the MVB pathway;   ubiquitin-dependent protein catabolism via the MVB pathway;   ubiquitin-dependent protein degradation via the multivesicular body pathway


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ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hdac6 histone deacetylase 6 JBrowse link X 15,295,372 15,316,673 RGD:1624291
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:1624291
RGD:1600115
G Plaa phospholipase A2, activating protein JBrowse link 5 113,548,913 113,578,928 RGD:1624291
RGD:1600115
G Ptpn23 protein tyrosine phosphatase, non-receptor type 23 JBrowse link 8 118,628,777 118,651,238 RGD:1600115
RGD:1624291
G Rnf115 ring finger protein 115 JBrowse link 2 198,852,392 198,920,000 RGD:1624291
G Rnf126 ring finger protein 126 JBrowse link 7 12,820,796 12,828,325 RGD:1624291
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1600115
RGD:1624291
G Ubap1 ubiquitin-associated protein 1 JBrowse link 5 57,738,309 57,778,724 RGD:1624291
RGD:13792537
RGD:1600115
G Ubap1l ubiquitin associated protein 1-like JBrowse link 8 70,876,516 70,895,723 RGD:13792537
G Vps28 VPS28 subunit of ESCRT-I JBrowse link 7 117,684,339 117,688,187 RGD:1624291
RGD:1600115
G Vps37a VPS37A subunit of ESCRT-I JBrowse link 16 54,860,811 54,899,410 RGD:1624291
RGD:13792537
G Vps37b VPS37B subunit of ESCRT-I JBrowse link 12 37,984,790 38,023,369 RGD:13792537
G Vps37c VPS37C subunit of ESCRT-I JBrowse link 1 226,742,267 226,774,109 RGD:13792537
G Vps37d VPS37D subunit of ESCRT-I JBrowse link 12 24,651,342 24,656,793 RGD:13792537
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:1624291
G Vps4b vacuolar protein sorting 4 homolog B JBrowse link 13 26,825,261 26,850,460 RGD:1624291
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Snf8 SNF8 subunit of ESCRT-II JBrowse link 10 83,856,331 83,868,621 RGD:13792537
G Vps25 vacuolar protein sorting 25 homolog JBrowse link 10 89,174,684 89,180,165 RGD:13792537
G Vps28 VPS28 subunit of ESCRT-I JBrowse link 7 117,684,339 117,688,187 RGD:1600115
RGD:13792537
G Vps36 vacuolar protein sorting 36 homolog JBrowse link 16 74,719,642 74,743,921 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      catabolic process 2437
        cellular catabolic process 2080
          cellular macromolecule catabolic process 1081
            modification-dependent macromolecule catabolic process 636
              modification-dependent protein catabolic process 625
                ubiquitin-dependent protein catabolic process 614
                  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 19
                    protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 4
Path 2
Term Annotations click to browse term
  biological_process 19336
    metabolic process 11555
      catabolic process 2437
        organic substance catabolic process 2001
          macromolecule catabolic process 1290
            cellular macromolecule catabolic process 1081
              cellular protein catabolic process 789
                proteolysis involved in cellular protein catabolic process 737
                  modification-dependent protein catabolic process 625
                    ubiquitin-dependent protein catabolic process 614
                      ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 19
                        protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.