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ONTOLOGY REPORT - ANNOTATIONS


Term:proteasome-mediated ubiquitin-dependent protein catabolic process
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Accession:GO:0043161 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Synonyms:exact_synonym: proteasomal pathway;   proteasomal ubiquitin-dependent protein breakdown;   proteasomal ubiquitin-dependent protein catabolic process;   proteasomal ubiquitin-dependent protein catabolism;   proteasomal ubiquitin-dependent protein degradation
 related_synonym: proteasomal processing;   proteasome pathway
 xref: MIPS_funcat:14.13.01.01


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proteasome-mediated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 JBrowse link 16 15,163,705 15,193,053 RGD:13508589
G AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 JBrowse link 8 47,798,946 47,819,364 RGD:13508589
G ARMC8 armadillo repeat containing 8 JBrowse link 23 34,401,684 34,511,962 RGD:13508589
G ARNTL aryl hydrocarbon receptor nuclear translocator like JBrowse link 21 36,254,235 36,323,915 RGD:13508589
G ATXN3 ataxin 3 JBrowse link 8 1,318,440 1,354,814 RGD:13508589
G BFAR bifunctional apoptosis regulator JBrowse link 6 28,593,931 28,624,867 RGD:13508589
G BIRC2 baculoviral IAP repeat containing 2 JBrowse link 5 29,294,080 29,314,837 RGD:13508589
G CDC34 cell division cycle 34 JBrowse link 20 57,960,506 57,967,388 RGD:13508589
G CRBN cereblon JBrowse link 20 14,240,723 14,275,617 RGD:13508589
G CTNNB1 catenin beta 1 JBrowse link 23 10,559,722 10,572,933 RGD:13508589
G CUL1 cullin 1 JBrowse link 16 1,995,637 2,086,853 RGD:13508589
G CUL2 cullin 2 JBrowse link 2 1,830,046 1,994,418 RGD:13508589
G CUL4A cullin 4A JBrowse link 22 60,624,215 60,667,844 RGD:13508589
G CUL4B cullin 4B JBrowse link X 92,489,981 92,538,199 RGD:13508589
G CUL5 cullin 5 JBrowse link 5 24,393,692 24,477,595 RGD:13508589
G DCAF11 DDB1 and CUL4 associated factor 11 JBrowse link 8 4,115,756 4,124,329 RGD:13508589
G DDB1 damage specific DNA binding protein 1 JBrowse link 18 55,064,720 55,097,623 RGD:13508589
G DDIT3 DNA damage inducible transcript 3 JBrowse link 10 1,606,693 1,612,410 RGD:13508589
G EPM2A EPM2A glucan phosphatase, laforin JBrowse link 1 36,835,775 36,977,653 RGD:13508589
G ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit JBrowse link 2 47,502,777 47,559,012 RGD:13508589
G FBXL19 F-box and leucine rich repeat protein 19 JBrowse link 6 17,254,595 17,274,103 RGD:13508589
G FBXO45 F-box protein 45 JBrowse link 33 29,627,762 29,642,175 RGD:13508589
G FBXW11 F-box and WD repeat domain containing 11 JBrowse link 4 40,238,695 40,363,445 RGD:13508589
G GID4 GID complex subunit 4 homolog JBrowse link 5 41,455,823 41,477,478 RGD:13508589
G GSK3A glycogen synthase kinase 3 alpha JBrowse link 1 112,129,116 112,138,714 RGD:13508589
G HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 JBrowse link 12 62,231,642 62,337,242 RGD:13508589
G HECTD3 HECT domain E3 ubiquitin protein ligase 3 JBrowse link 15 15,319,264 15,328,034 RGD:13508589
G HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 18 6,644,102 7,084,159 RGD:13508589
G HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 37 5,850,518 6,213,353 RGD:13508589
G ITCH itchy E3 ubiquitin protein ligase JBrowse link 24 23,476,619 23,630,574 RGD:13508589
G KCTD10 potassium channel tetramerization domain containing 10 JBrowse link 26 17,592,157 17,625,384 RGD:13508589
G KCTD13 potassium channel tetramerization domain containing 13 JBrowse link 6 17,945,541 17,959,421 RGD:13508589
G KCTD2 potassium channel tetramerization domain containing 2 JBrowse link 9 5,417,352 5,432,819 RGD:13508589
G KCTD5 potassium channel tetramerization domain containing 5 JBrowse link 6 38,403,024 38,426,158 RGD:13508589
G KLHL20 kelch like family member 20 JBrowse link 7 25,430,490 25,484,245 RGD:13508589
G KLHL42 kelch like family member 42 JBrowse link 27 19,945,465 19,962,742 RGD:13508589
G LOC102152879 proteasome subunit alpha type-1-like JBrowse link 30 24,114,023 24,116,951 RGD:13508589
G LOC479005 E3 ubiquitin-protein ligase HERC2 JBrowse link 3 31,723,113 31,966,061 RGD:13508589
G LTN1 listerin E3 ubiquitin protein ligase 1 JBrowse link 31 23,942,493 24,008,787 RGD:13508589
G MAEA macrophage erythroblast attacher JBrowse link 3 62,679,084 62,718,154 RGD:13508589
G MND1 meiotic nuclear divisions 1 JBrowse link 15 51,151,794 51,214,736 RGD:13508589
G MTA1 metastasis associated 1 JBrowse link 8 72,752,894 72,772,236 RGD:13508589
G NEDD4 NEDD4 E3 ubiquitin protein ligase JBrowse link 30 21,123,333 21,229,907 RGD:13508589
G NEDD4L NEDD4 like E3 ubiquitin protein ligase JBrowse link 1 17,629,163 17,858,471 RGD:13508589
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 36 20,989,205 21,087,044 RGD:13508589
G NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 JBrowse link 35 16,920,687 16,921,829 RGD:13508589
G NHLRC3 NHL repeat containing 3 JBrowse link 25 1,976,946 2,036,161 RGD:13508589
G NSFL1C NSFL1 cofactor JBrowse link 24 19,575,543 19,599,002 RGD:13508589
G PELI1 pellino E3 ubiquitin protein ligase 1 JBrowse link 10 63,727,905 63,863,599 RGD:13508589
G PLAA phospholipase A2 activating protein JBrowse link 11 45,121,423 45,159,093 RGD:13508589
G PPP2CB protein phosphatase 2 catalytic subunit beta JBrowse link 16 33,532,703 33,567,011 RGD:13508589
G PRICKLE2 prickle planar cell polarity protein 2 JBrowse link 20 26,810,167 27,131,864 RGD:13508589
G PSMA3 proteasome 20S subunit alpha 3 JBrowse link 8 33,616,735 33,642,434 RGD:13508589
G PSMA5 proteasome 20S subunit alpha 5 JBrowse link 6 42,425,590 42,450,074 RGD:13508589
G PSMA6 proteasome 20S subunit alpha 6 JBrowse link 8 14,010,899 14,038,141 RGD:13508589
G PSMA7 proteasome 20S subunit alpha 7 JBrowse link 24 46,182,344 46,186,241 RGD:13508589
G PSMA8 proteasome 20S subunit alpha 8 JBrowse link 7 62,432,477 62,472,984 RGD:13508589
G PSMB1 proteasome 20S subunit beta 1 JBrowse link 12 72,440,224 72,456,304 RGD:13508589
G PSMB10 proteasome 20S subunit beta 10 JBrowse link 5 81,560,750 81,563,571 RGD:13508589
G PSMB2 proteasome 20S subunit beta 2 JBrowse link 15 6,511,281 6,544,859 RGD:13508589
G PSMB3 proteasome 20S subunit beta 3 JBrowse link 9 23,474,476 23,484,408 RGD:13508589
G PSMB4 proteasome 20S subunit beta 4 JBrowse link 17 60,461,208 60,463,604 RGD:13508589
G PSMB5 proteasome 20S subunit beta 5 JBrowse link 8 3,344,157 3,349,921 RGD:13508589
G PSMB6 proteasome 20S subunit beta 6 JBrowse link 5 31,776,286 31,778,789 RGD:13508589
G PSMB7 proteasome 20S subunit beta 7 JBrowse link 9 58,529,646 58,593,016 RGD:13508589
G PSMB8 proteasome 20S subunit beta 8 JBrowse link 12 2,419,456 2,422,832 RGD:13508589
G PSMB9 proteasome 20S subunit beta 9 JBrowse link 12 2,432,287 2,438,920 RGD:13508589
G PSMC5 proteasome 26S subunit, ATPase 5 JBrowse link 9 11,783,422 11,787,624 RGD:13508589
G PSMD1 proteasome 26S subunit, non-ATPase 1 JBrowse link 25 43,003,127 43,096,281 RGD:13508589
G PSMD12 proteasome 26S subunit, non-ATPase 12 JBrowse link 9 13,136,883 13,170,544 RGD:13508589
G PSMD14 proteasome 26S subunit, non-ATPase 14 JBrowse link 36 6,883,612 6,985,291 RGD:13508589
G PSMD2 proteasome 26S subunit, non-ATPase 2 JBrowse link 34 17,180,119 17,189,298 RGD:13508589
G PSMD4 proteasome 26S subunit, non-ATPase 4 JBrowse link 17 60,306,134 60,313,610 RGD:13508589
G PSMD7 proteasome 26S subunit, non-ATPase 7 JBrowse link 5 79,785,620 79,793,793 RGD:13508589
G PSMD8 proteasome 26S subunit, non-ATPase 8 JBrowse link 1 114,619,478 114,626,082 RGD:13508589
G RAD23A RAD23 homolog A, nucleotide excision repair protein JBrowse link 20 49,244,330 49,250,058 RGD:13508589
G RAD23B RAD23 homolog B, nucleotide excision repair protein JBrowse link 11 62,732,989 62,778,957 RGD:13508589
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 24 20,423,378 20,440,985 RGD:13508589
G RMND5A required for meiotic nuclear division 5 homolog A JBrowse link 17 38,408,946 38,472,342 RGD:13508589
G RMND5B required for meiotic nuclear division 5 homolog B JBrowse link 11 3,393,852 3,409,484 RGD:13508589
G RNF122 ring finger protein 122 JBrowse link 16 31,132,478 31,145,642 RGD:13508589
G RNF186 ring finger protein 186 JBrowse link 2 78,915,131 78,916,909 RGD:13508589
G RNF216 ring finger protein 216 JBrowse link 6 12,185,870 12,347,461 RGD:13508589
G RNF34 ring finger protein 34 JBrowse link 26 7,746,460 7,767,967 RGD:13508589
G RNF4 ring finger protein 4 JBrowse link 3 61,721,752 61,759,797 RGD:13508589
G SIAH1 siah E3 ubiquitin protein ligase 1 JBrowse link 2 66,630,795 66,709,497 RGD:13508589
G SMURF1 SMAD specific E3 ubiquitin protein ligase 1 JBrowse link 6 10,385,781 10,498,071 RGD:13508589
G SPOP speckle type BTB/POZ protein JBrowse link 9 25,685,723 25,752,953 RGD:13508589
G SPOPL speckle type BTB/POZ protein like JBrowse link 19 41,167,511 41,240,741 RGD:13508589
G SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 JBrowse link 5 62,640,420 62,669,606 RGD:13508589
G SPSB2 splA/ryanodine receptor domain and SOCS box containing 2 JBrowse link 27 38,134,855 38,154,520 RGD:13508589
G SPSB3 splA/ryanodine receptor domain and SOCS box containing 3 JBrowse link 6 39,122,148 39,127,444 RGD:13508589
G SPSB4 splA/ryanodine receptor domain and SOCS box containing 4 JBrowse link 23 36,998,124 37,082,576 RGD:13508589
G TBL1XR1 TBL1X receptor 1 JBrowse link 34 40,573,631 40,690,975 RGD:13508589
G TBX21 T-box transcription factor 21 JBrowse link 9 24,077,752 24,086,560 RGD:13508589
G TNFAIP1 TNF alpha induced protein 1 JBrowse link 9 42,588,009 42,597,961 RGD:13508589
G TOPORS TOP1 binding arginine/serine rich protein JBrowse link 11 49,809,156 49,821,224 RGD:13508589
G TRIM3 tripartite motif containing 3 JBrowse link 21 29,766,086 29,782,573 RGD:13508589
G TRIM71 tripartite motif containing 71 JBrowse link 23 3,888,287 3,959,910 RGD:13508589
G TRIM9 tripartite motif containing 9 JBrowse link 8 27,334,045 27,441,238 RGD:13508589
G UBE2A ubiquitin conjugating enzyme E2 A JBrowse link X 91,608,936 91,617,993 RGD:13508589
G UBE2B ubiquitin conjugating enzyme E2 B JBrowse link 11 22,523,671 22,541,473 RGD:13508589
G UBE2G1 ubiquitin conjugating enzyme E2 G1 JBrowse link 5 30,332,277 30,430,225 RGD:13508589
G UBE2H ubiquitin conjugating enzyme E2 H JBrowse link 14 6,912,742 7,022,029 RGD:13508589
G UBE2K ubiquitin conjugating enzyme E2 K JBrowse link 3 72,713,035 72,780,199 RGD:13508589
G UBE2U ubiquitin conjugating enzyme E2 U JBrowse link 5 45,947,637 45,998,353 RGD:13508589
G UBE2W ubiquitin conjugating enzyme E2 W JBrowse link 29 22,307,192 22,409,667 RGD:13508589
G UBE3D ubiquitin protein ligase E3D JBrowse link 12 43,264,956 43,475,583 RGD:13508589
G UBE4B ubiquitination factor E4B JBrowse link 5 63,214,846 63,339,218 RGD:13508589
G UBXN11 UBX domain protein 11 JBrowse link 2 73,714,722 73,736,716 RGD:13508589
G UBXN2A UBX domain protein 2A JBrowse link 17 18,446,856 18,491,797 RGD:13508589
G UBXN2B UBX domain protein 2B JBrowse link 29 9,229,070 9,258,269 RGD:13508589
G USP44 ubiquitin specific peptidase 44 JBrowse link 15 35,401,486 35,454,351 RGD:13508589
G WWP1 WW domain containing E3 ubiquitin protein ligase 1 JBrowse link 29 32,523,719 32,620,507 RGD:13508589
G WWP2 WW domain containing E3 ubiquitin protein ligase 2 JBrowse link 5 79,806,424 79,926,846 RGD:13508589
G ZFAND2B zinc finger AN1-type containing 2B JBrowse link 37 25,757,454 25,760,366 RGD:13508589
anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANAPC1 anaphase promoting complex subunit 1 JBrowse link 17 36,210,026 36,313,785 RGD:13508589
G ANAPC10 anaphase promoting complex subunit 10 JBrowse link 15 43,528,978 43,781,843 RGD:13508589
G ANAPC4 anaphase promoting complex subunit 4 JBrowse link 3 84,878,686 84,914,876 RGD:13508589
G ANAPC5 anaphase promoting complex subunit 5 JBrowse link 26 7,796,736 7,840,726 RGD:13508589
G ANAPC7 anaphase promoting complex subunit 7 JBrowse link 26 8,223,627 8,247,976 RGD:13508589
G CDC16 cell division cycle 16 JBrowse link 22 61,283,263 61,312,283 RGD:13508589
G CDC20 cell division cycle 20 JBrowse link 15 16,803,204 16,806,935 RGD:13508589
G CDC23 cell division cycle 23 JBrowse link 11 25,834,752 25,851,588 RGD:13508589
G CDC26 cell division cycle 26 JBrowse link 11 67,632,887 67,641,291 RGD:13508589
G CDC27 cell division cycle 27 JBrowse link 9 9,281,152 9,351,629 RGD:13508589
G CUL3 cullin 3 JBrowse link 25 37,730,903 37,819,851 RGD:13508589
G ECRG4 ECRG4 augurin precursor JBrowse link 10 37,423,183 37,432,961 RGD:13508589
G FBXO31 F-box protein 31 JBrowse link 5 65,703,591 65,734,956 RGD:13508589
G UBE2C ubiquitin conjugating enzyme E2 C JBrowse link 24 33,128,300 33,133,637 RGD:13508589
G UBE2S ubiquitin conjugating enzyme E2 S JBrowse link 1 102,283,171 102,287,460 RGD:13508589
mannose trimming involved in glycoprotein ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 JBrowse link 20 12,444,013 12,473,188 RGD:13508589
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 JBrowse link 24 24,137,228 24,165,995 RGD:13508589
G EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 JBrowse link 7 17,918,902 17,991,270 RGD:13508589
mitochondria-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 37 25,777,665 25,783,892 RGD:13508589
negative regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 20 56,432,688 56,451,438 RGD:13508589
G USP14 ubiquitin specific peptidase 14 JBrowse link 7 67,035,774 67,080,082 RGD:13508589
negative regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAG5 BAG cochaperone 5 JBrowse link 8 71,318,730 71,324,743 RGD:13508589
G BAG6 BAG cochaperone 6 JBrowse link 12 1,126,730 1,141,978 RGD:13508589
G CAMLG calcium modulating ligand JBrowse link 11 22,818,699 22,829,737 RGD:13508589
G CCAR2 cell cycle and apoptosis regulator 2 JBrowse link 25 34,660,026 34,674,129 RGD:13508589
G CLEC16A C-type lectin domain containing 16A JBrowse link 6 31,560,940 31,757,100 RGD:13508589
G DDRGK1 DDRGK domain containing 1 JBrowse link 24 18,085,865 18,098,868 RGD:13508589
G FHIT fragile histidine triad diadenosine triphosphatase JBrowse link 20 29,735,380 31,113,859 RGD:13508589
G GIPC1 GIPC PDZ domain containing family member 1 JBrowse link 20 48,144,076 48,155,069 RGD:13508589
G HSP90AB1 heat shock protein 90 alpha family class B member 1 JBrowse link 12 12,658,415 12,664,945 RGD:13508589
G KLHL40 kelch like family member 40 JBrowse link 23 11,812,268 11,820,426 RGD:13508589
G MTM1 myotubularin 1 JBrowse link X 118,820,644 118,917,166 RGD:13508589
G N4BP1 NEDD4 binding protein 1 JBrowse link 2 66,544,665 66,565,858 RGD:13508589
G NOP53 NOP53 ribosome biogenesis factor JBrowse link 1 108,307,039 108,315,732 RGD:13508589
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 55,821,227 55,857,597 RGD:13508589
G PBK PDZ binding kinase JBrowse link 25 29,751,805 29,781,806 RGD:13508589
G RYBP RING1 and YY1 binding protein JBrowse link 20 19,650,936 19,732,987 RGD:13508589
G SENP1 SUMO specific peptidase 1 JBrowse link 27 6,664,750 6,719,257 RGD:13508589
G SHH sonic hedgehog signaling molecule JBrowse link 16 18,650,553 18,663,571 RGD:13508589
G SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 JBrowse link 20 41,165,593 41,337,237 RGD:13508589
G TLK2 tousled like kinase 2 JBrowse link 9 10,686,424 10,804,885 RGD:13508589
G UBXN1 UBX domain protein 1 JBrowse link 18 53,977,937 53,982,108 RGD:13508589
G USP7 ubiquitin specific peptidase 7 JBrowse link 6 33,277,328 33,315,601 RGD:13508589
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G STYX serine/threonine/tyrosine interacting protein JBrowse link 8 28,949,732 28,990,455 RGD:13508589
nuclear protein quality control by the ubiquitin-proteasome system term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 37 25,777,665 25,783,892 RGD:13508589
G CUL3 cullin 3 JBrowse link 25 37,730,903 37,819,851 RGD:13508589
G KLHL15 kelch like family member 15 JBrowse link X 19,617,629 19,651,076 RGD:13508589
positive regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BCAP31 B cell receptor associated protein 31 JBrowse link X 121,515,417 121,550,373 RGD:13508589
G CAV1 caveolin 1 JBrowse link 14 55,458,934 55,494,563 RGD:13508589
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 2 59,388,492 59,400,028 RGD:13508589
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 20 56,432,688 56,451,438 RGD:13508589
G UBQLN1 ubiquilin 1 JBrowse link 1 75,767,345 75,812,278 RGD:13508589
positive regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKT1 AKT serine/threonine kinase 1 JBrowse link 8 72,317,399 72,335,686 RGD:13508589
G ANKIB1 ankyrin repeat and IBR domain containing 1 JBrowse link 14 17,835,582 18,007,077 RGD:13508589
G ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 JBrowse link 30 35,927,277 36,040,168 RGD:13508589
G ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 JBrowse link 20 40,178,560 40,230,870 RGD:13508589
G BBS4 Bardet-Biedl syndrome 4 JBrowse link 30 36,058,932 36,109,206 RGD:13508589
G BBS7 Bardet-Biedl syndrome 7 JBrowse link 19 18,280,487 18,319,128 RGD:13508589
G CHFR checkpoint with forkhead and ring finger domains JBrowse link 26 251,369 324,699 RGD:13508589
G CLU clusterin JBrowse link 25 29,982,811 29,999,565 RGD:13508589
G CSNK1D casein kinase 1 delta JBrowse link 9 83,395 110,309 RGD:13508589
G CSNK1E casein kinase 1 epsilon JBrowse link 10 26,386,646 26,412,429 RGD:13508589
G DDA1 DET1 and DDB1 associated 1 JBrowse link 20 45,440,046 45,448,564 RGD:13508589
G DDRGK1 DDRGK domain containing 1 JBrowse link 24 18,085,865 18,098,868 RGD:13508589
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 37 25,826,496 25,834,011 RGD:13508589
G DVL1 dishevelled segment polarity protein 1 JBrowse link 5 56,507,803 56,519,382 RGD:13508589
G GBA glucosylceramidase beta JBrowse link 7 42,317,704 42,322,285 RGD:13508589
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 12 20,999,815 21,047,779 RGD:13508589
G GSK3B glycogen synthase kinase 3 beta JBrowse link 33 23,458,369 23,659,878 RGD:13508589
G HSP70 heat shock protein 70 JBrowse link 12 1,285,282 1,287,670 RGD:13508589
G HSPBP1 HSPA (Hsp70) binding protein 1 JBrowse link 1 102,389,438 102,402,578 RGD:13508589
G LRRK2 leucine rich repeat kinase 2 JBrowse link 27 13,282,824 13,420,917 RGD:13508589
G NKD2 NKD inhibitor of WNT signaling pathway 2 JBrowse link 34 11,447,895 11,468,067 RGD:13508589
G NOP53 NOP53 ribosome biogenesis factor JBrowse link 1 108,307,039 108,315,732 RGD:13508589
G PLK1 polo like kinase 1 JBrowse link 6 22,165,338 22,176,847 RGD:13508589
G PRICKLE1 prickle planar cell polarity protein 1 JBrowse link 27 11,327,086 11,437,799 RGD:13508589
G PRKN parkin RBR E3 ubiquitin protein ligase JBrowse link 1 49,886,887 51,201,930 RGD:13508589
G PSEN1 presenilin 1 JBrowse link 8 46,495,551 46,569,532 RGD:13508589
G PSMD10 proteasome 26S subunit, non-ATPase 10 JBrowse link X 81,625,288 81,632,175 RGD:13508589
G RACK1 receptor for activated C kinase 1 JBrowse link 11 426,734 431,087 RGD:13508589
G RCHY1 ring finger and CHY zinc finger domain containing 1 JBrowse link 32 67,136 94,053 RGD:13508589
G RNF14 ring finger protein 14 JBrowse link 2 36,908,617 36,934,896 RGD:13508589
G RNF144A ring finger protein 144A JBrowse link 17 4,522,095 4,637,741 RGD:13508589
G RNF144B ring finger protein 144B JBrowse link 35 17,056,189 17,226,254 RGD:13508589
G RNF180 ring finger protein 180 JBrowse link 2 50,166,987 50,353,694 RGD:13508589
G RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase JBrowse link 13 2,142,126 2,170,530 RGD:13508589
G RNF19B ring finger protein 19B JBrowse link 2 68,413,020 68,435,216 RGD:13508589
G RNF217 ring finger protein 217 JBrowse link 1 63,902,985 64,094,491 RGD:13508589
G SH3RF2 SH3 domain containing ring finger 2 JBrowse link 2 40,380,313 40,514,211 RGD:13508589
G SMAD7 SMAD family member 7 JBrowse link 7 79,706,485 79,734,673 RGD:13508589
G SOCS4 suppressor of cytokine signaling 4 JBrowse link 8 30,892,663 30,898,896 RGD:13508589
G SOCS5 suppressor of cytokine signaling 5 JBrowse link 10 48,916,446 48,977,183 RGD:13508589
G STUB1 STIP1 homology and U-box containing protein 1 JBrowse link 6 39,893,492 39,895,385 RGD:13508589
G SUMO1 small ubiquitin like modifier 1 JBrowse link 37 11,199,937 11,229,743 RGD:13508589
G TRIB1 tribbles pseudokinase 1 JBrowse link 13 23,337,788 23,346,304 RGD:13508589
G TRIB2 tribbles pseudokinase 2 JBrowse link 17 9,225,598 9,251,826 RGD:13508589
G USP5 ubiquitin specific peptidase 5 JBrowse link 27 38,158,850 38,172,689 RGD:13508589
G VCP valosin containing protein JBrowse link 11 51,636,986 51,651,749 RGD:13508589
G ZER1 zyg-11 related cell cycle regulator JBrowse link 9 54,842,607 54,873,336 RGD:13508589
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G PLK3 polo like kinase 3 JBrowse link 15 15,519,042 15,523,960 RGD:13508589
positive regulation of transcription factor catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 11 1,443,528 1,480,501 RGD:13508589
G SIRT6 sirtuin 6 JBrowse link 20 55,412,989 55,424,944 RGD:13508589
regulation of ER-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 2 59,388,492 59,400,028 RGD:13508589
regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G COMMD1 copper metabolism domain containing 1 JBrowse link 10 61,886,281 62,059,610 RGD:13508589
G FOXF2 forkhead box F2 JBrowse link 35 1,841,165 1,846,649 RGD:13508589
G GLMN glomulin, FKBP associated protein JBrowse link 6 56,631,186 56,678,397 RGD:13508589
G GNA12 G protein subunit alpha 12 JBrowse link 6 14,375,144 14,476,018 RGD:13508589
G RAD23B RAD23 homolog B, nucleotide excision repair protein JBrowse link 11 62,732,989 62,778,957 RGD:13508589
G UBE2K ubiquitin conjugating enzyme E2 K JBrowse link 3 72,713,035 72,780,199 RGD:13508589
G UBQLN4 ubiquilin 4 JBrowse link 7 41,764,209 41,778,457 RGD:13508589
G UFL1 UFM1 specific ligase 1 JBrowse link 12 54,988,200 55,023,414 RGD:13508589
G WNT10B Wnt family member 10B JBrowse link 27 5,599,905 5,605,506 RGD:13508589
ribosome-associated ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LTN1 listerin E3 ubiquitin protein ligase 1 JBrowse link 31 23,942,493 24,008,787 RGD:13508589
G NEMF nuclear export mediator factor JBrowse link 8 26,364,664 26,411,475 RGD:13508589
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 28 13,988,408 14,173,223 RGD:13508589
G CCNF cyclin F JBrowse link 6 38,572,883 38,592,465 RGD:13508589
G CUL1 cullin 1 JBrowse link 16 1,995,637 2,086,853 RGD:13508589
G CUL2 cullin 2 JBrowse link 2 1,830,046 1,994,418 RGD:13508589
G CUL4A cullin 4A JBrowse link 22 60,624,215 60,667,844 RGD:13508589
G CUL4B cullin 4B JBrowse link X 92,489,981 92,538,199 RGD:13508589
G CUL5 cullin 5 JBrowse link 5 24,393,692 24,477,595 RGD:13508589
G DMAC2 distal membrane arm assembly complex 2 JBrowse link 1 112,567,786 112,573,471 RGD:13508589
G FBXL12 F-box and leucine rich repeat protein 12 JBrowse link 20 51,183,064 51,187,605 RGD:13508589
G FBXL13 F-box and leucine rich repeat protein 13 JBrowse link 18 17,020,564 17,225,103 RGD:13508589
G FBXL14 F-box and leucine rich repeat protein 14 JBrowse link 27 43,617,087 43,625,269 RGD:13508589
G FBXL15 F-box and leucine rich repeat protein 15 JBrowse link 28 14,927,740 14,929,867 RGD:13508589
G FBXL16 F-box and leucine rich repeat protein 16 JBrowse link 6 39,879,314 39,884,995 RGD:13508589
G FBXL18 F-box and leucine rich repeat protein 18 JBrowse link 6 12,434,983 12,479,702 RGD:13508589
G FBXL2 F-box and leucine rich repeat protein 2 JBrowse link 23 3,498,253 3,606,016 RGD:13508589
G FBXL20 F-box and leucine rich repeat protein 20 JBrowse link 9 23,021,103 23,122,768 RGD:13508589
G FBXL22 F-box and leucine rich repeat protein 22 JBrowse link 30 28,187,452 28,191,019 RGD:13508589
G FBXL3 F-box and leucine rich repeat protein 3 JBrowse link 22 30,579,598 30,598,879 RGD:13508589
G FBXL4 F-box and leucine rich repeat protein 4 JBrowse link 12 57,139,183 57,211,157 RGD:13508589
G FBXL5 F-box and leucine rich repeat protein 5 JBrowse link 3 64,683,770 64,727,161 RGD:13508589
G FBXL6 F-box and leucine rich repeat protein 6 JBrowse link 13 37,780,991 37,783,976 RGD:13508589
G FBXL7 F-box and leucine rich repeat protein 7 JBrowse link 4 87,348,187 87,637,517 RGD:13508589
G FBXL8 F-box and leucine rich repeat protein 8 JBrowse link 5 82,201,732 82,206,058 RGD:13508589
G FBXO17 F-box protein 17 JBrowse link 1 114,161,226 114,188,354 RGD:13508589
G FBXO2 F-box protein 2 JBrowse link 2 84,563,256 84,568,507 RGD:13508589
G FBXO27 F-box protein 27 JBrowse link 1 114,120,617 114,145,295 RGD:13508589
G FBXO31 F-box protein 31 JBrowse link 5 65,703,591 65,734,956 RGD:13508589
G FBXO33 F-box protein 33 JBrowse link 8 17,495,795 17,528,389 RGD:13508589
G FBXO38 F-box protein 38 JBrowse link 4 60,360,543 60,416,727 RGD:13508589
G FBXO39 F-box protein 39 JBrowse link 5 30,619,510 30,624,377 RGD:13508589
G FBXO4 F-box protein 4 JBrowse link 4 67,620,947 67,664,862 RGD:13508589
G FBXO48 F-box protein 48 JBrowse link 10 67,449,168 67,453,540 RGD:13508589
G FBXO6 F-box protein 6 JBrowse link 2 84,549,519 84,554,176 RGD:13508589
G FBXO9 F-box protein 9 JBrowse link 12 20,514,590 20,562,507 RGD:13508589
G FBXW11 F-box and WD repeat domain containing 11 JBrowse link 4 40,238,695 40,363,445 RGD:13508589
G FBXW4 F-box and WD repeat domain containing 4 JBrowse link 28 14,219,724 14,336,846 RGD:13508589
G FBXW5 F-box and WD repeat domain containing 5 JBrowse link 9 48,674,299 48,678,846 RGD:13508589
G FBXW7 F-box and WD repeat domain containing 7 JBrowse link 15 50,187,579 50,417,188 RGD:13508589
G KIF14 kinesin family member 14 JBrowse link 7 2,548,407 2,602,371 RGD:13508589
G NCCRP1 NCCRP1, F-box associated domain containing JBrowse link 1 113,989,951 113,993,847 RGD:13508589
G RNF7 ring finger protein 7 JBrowse link 23 37,578,222 37,584,862 RGD:13508589
G SKP1 S-phase kinase associated protein 1 JBrowse link 11 22,352,735 22,366,599 RGD:13508589
G SKP2 S-phase kinase associated protein 2 JBrowse link 4 72,352,966 72,386,469 RGD:13508589
G WWTR1 WW domain containing transcription regulator 1 JBrowse link 23 44,277,707 44,409,911 RGD:13508589
ubiquitin-dependent ERAD pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AMFR autocrine motility factor receptor JBrowse link 2 59,766,910 59,803,292 RGD:13508589
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 JBrowse link 37 25,777,665 25,783,892 RGD:13508589
G AUP1 AUP1 lipid droplet regulating VLDL assembly factor JBrowse link 17 48,613,648 48,617,091 RGD:13508589
G BAG6 BAG cochaperone 6 JBrowse link 12 1,126,730 1,141,978 RGD:13508589
G CCDC47 coiled-coil domain containing 47 JBrowse link 9 11,715,793 11,737,055 RGD:13508589
G DERL1 derlin 1 JBrowse link 13 21,423,501 21,452,594 RGD:13508589
G DERL2 derlin 2 JBrowse link 5 31,319,660 31,330,846 RGD:13508589
G DERL3 derlin 3 JBrowse link 26 28,688,307 28,690,400 RGD:13508589
G DNAJB12 DnaJ heat shock protein family (Hsp40) member B12 JBrowse link 4 22,964,098 22,980,291 RGD:13508589
G DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 JBrowse link 32 21,840,790 21,888,400 RGD:13508589
G DNAJB2 DnaJ heat shock protein family (Hsp40) member B2 JBrowse link 37 25,826,496 25,834,011 RGD:13508589
G DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 JBrowse link 36 25,749,855 25,822,117 RGD:13508589
G DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 JBrowse link 2 34,730,877 34,762,234 RGD:13508589
G ERLEC1 endoplasmic reticulum lectin 1 JBrowse link 10 54,815,592 54,845,776 RGD:13508589
G ERLIN1 ER lipid raft associated 1 JBrowse link 28 12,924,942 12,962,016 RGD:13508589
G ERLIN2 ER lipid raft associated 2 JBrowse link 16 27,622,549 27,639,807 RGD:13508589
G FAF2 Fas associated factor family member 2 JBrowse link 4 36,819,754 36,890,901 RGD:13508589
G FBXO17 F-box protein 17 JBrowse link 1 114,161,226 114,188,354 RGD:13508589
G FBXO2 F-box protein 2 JBrowse link 2 84,563,256 84,568,507 RGD:13508589
G FBXO27 F-box protein 27 JBrowse link 1 114,120,617 114,145,295 RGD:13508589
G FBXO6 F-box protein 6 JBrowse link 2 84,549,519 84,554,176 RGD:13508589
G FOXRED2 FAD dependent oxidoreductase domain containing 2 JBrowse link 10 27,908,090 27,923,602 RGD:13508589
G HSP90B1 heat shock protein 90 beta family member 1 JBrowse link 15 42,456,793 42,474,122 RGD:13508589
G HSPA5 heat shock protein family A (Hsp70) member 5 JBrowse link 9 57,850,870 57,855,607 RGD:13508589
G LOC100687259 26S proteasome regulatory subunit 10B JBrowse link 32 35,814,756 35,816,311 RGD:13508589
G LOC480667 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase JBrowse link 9 48,533,962 48,545,514 RGD:13508589
G LOC607002 endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like JBrowse link 9 48,558,440 48,561,174 RGD:13508589
G MARCHF6 membrane associated ring-CH-type finger 6 JBrowse link 34 3,880,988 3,947,127 RGD:13508589
G NCCRP1 NCCRP1, F-box associated domain containing JBrowse link 1 113,989,951 113,993,847 RGD:13508589
G OS9 OS9 endoplasmic reticulum lectin JBrowse link 10 1,757,070 1,787,822 RGD:13508589
G RHBDD2 rhomboid domain containing 2 JBrowse link 6 7,218,796 7,230,949 RGD:13508589
G RNF103 ring finger protein 103 JBrowse link 17 38,549,838 38,566,613 RGD:13508589
G RNF121 ring finger protein 121 JBrowse link 21 26,080,885 26,163,570 RGD:13508589
G RNF5 ring finger protein 5 JBrowse link 12 1,571,277 1,575,151 RGD:13508589
G SEC61B SEC61 translocon beta subunit JBrowse link 11 56,279,564 56,298,593 RGD:13508589
G SEL1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligase JBrowse link 8 53,767,799 53,824,391 RGD:13508589
G SEL1L2 SEL1L2 adaptor subunit of ERAD E3 ligase JBrowse link 24 8,678,528 8,812,373 RGD:13508589
G SELENOS selenoprotein S JBrowse link 3 39,796,711 39,805,654 RGD:13508589
G SGTA small glutamine rich tetratricopeptide repeat containing alpha JBrowse link 20 56,432,688 56,451,438 RGD:13508589
G SGTB small glutamine rich tetratricopeptide repeat containing beta JBrowse link 2 51,397,606 51,446,512 RGD:13508589
G STT3B STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 23 13,036,301 13,143,629 RGD:13508589
G STUB1 STIP1 homology and U-box containing protein 1 JBrowse link 6 39,893,492 39,895,385 RGD:13508589
G SYVN1 synoviolin 1 JBrowse link 18 52,061,284 52,068,672 RGD:13508589
G TMEM129 transmembrane protein 129 JBrowse link 3 62,381,240 62,386,381 RGD:13508589
G TMUB1 transmembrane and ubiquitin like domain containing 1 JBrowse link 16 15,131,190 15,134,230 RGD:13508589
G TMUB2 transmembrane and ubiquitin like domain containing 2 JBrowse link 9 19,204,802 19,209,275 RGD:13508589
G TRIM13 tripartite motif containing 13 JBrowse link 22 1,877,672 1,893,097 RGD:13508589
G TRIM25 tripartite motif containing 25 JBrowse link 9 31,703,628 31,725,674 RGD:13508589
G UBE2G2 ubiquitin conjugating enzyme E2 G2 JBrowse link 31 38,432,855 38,470,202 RGD:13508589
G UBE2J1 ubiquitin conjugating enzyme E2 J1 JBrowse link 12 48,542,432 48,570,716 RGD:13508589
G UBE2J2 ubiquitin conjugating enzyme E2 J2 JBrowse link 5 56,440,394 56,455,491 RGD:13508589
G UBE4A ubiquitination factor E4A JBrowse link 5 15,338,279 15,375,722 RGD:13508589
G UBE4B ubiquitination factor E4B JBrowse link 5 63,214,846 63,339,218 RGD:13508589
G UBQLN1 ubiquilin 1 JBrowse link 1 75,767,345 75,812,278 RGD:13508589
G UBXN4 UBX domain protein 4 JBrowse link 19 38,519,778 38,568,760 RGD:13508589
G UBXN8 UBX domain protein 8 JBrowse link 16 33,590,905 33,622,752 RGD:13508589
G USP19 ubiquitin specific peptidase 19 JBrowse link 20 40,062,802 40,074,221 RGD:13508589
G VCP valosin containing protein JBrowse link 11 51,636,986 51,651,749 RGD:13508589
G WFS1 wolframin ER transmembrane glycoprotein JBrowse link 13 38,451,722 38,466,481 RGD:13508589
G YOD1 YOD1 deubiquitinase JBrowse link 7 6,185,650 6,194,005 RGD:13508589
ubiquitin-dependent protein catabolic process via the N-end rule pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 JBrowse link 30 9,869,769 10,006,994 RGD:13508589
G UBR2 ubiquitin protein ligase E3 component n-recognin 2 JBrowse link 12 11,167,286 11,296,817 RGD:13508589
G UBR3 ubiquitin protein ligase E3 component n-recognin 3 JBrowse link 36 14,537,900 14,723,942 RGD:13508589

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13644
    metabolic process 8513
      primary metabolic process 7715
        protein metabolic process 4191
          protein catabolic process 687
            proteasomal protein catabolic process 356
              proteasome-mediated ubiquitin-dependent protein catabolic process 308
                SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 45
                anaphase-promoting complex-dependent catabolic process + 15
                cytoplasm protein quality control by the ubiquitin-proteasome system 0
                mitochondria-associated ubiquitin-dependent protein catabolic process 1
                negative regulation of proteasomal ubiquitin-dependent protein catabolic process + 25
                nuclear protein quality control by the ubiquitin-proteasome system + 3
                positive regulation of proteasomal ubiquitin-dependent protein catabolic process + 55
                regulation of proteasomal ubiquitin-dependent protein catabolic process + 86
                ribosome-associated ubiquitin-dependent protein catabolic process 2
                stress-induced homeostatically regulated protein degradation pathway 0
                transcription factor catabolic process + 2
                ubiquitin-dependent ERAD pathway + 67
                ubiquitin-dependent protein catabolic process via the N-end rule pathway 3
Path 2
Term Annotations click to browse term
  biological_process 13644
    metabolic process 8513
      nitrogen compound metabolic process 7299
        organonitrogen compound metabolic process 4829
          organonitrogen compound catabolic process 891
            protein catabolic process 687
              cellular protein catabolic process 582
                proteolysis involved in cellular protein catabolic process 553
                  modification-dependent protein catabolic process 478
                    ubiquitin-dependent protein catabolic process 468
                      proteasome-mediated ubiquitin-dependent protein catabolic process 308
                        SCF-dependent proteasomal ubiquitin-dependent protein catabolic process + 45
                        anaphase-promoting complex-dependent catabolic process + 15
                        cytoplasm protein quality control by the ubiquitin-proteasome system 0
                        mitochondria-associated ubiquitin-dependent protein catabolic process 1
                        negative regulation of proteasomal ubiquitin-dependent protein catabolic process + 25
                        nuclear protein quality control by the ubiquitin-proteasome system + 3
                        positive regulation of proteasomal ubiquitin-dependent protein catabolic process + 55
                        regulation of proteasomal ubiquitin-dependent protein catabolic process + 86
                        ribosome-associated ubiquitin-dependent protein catabolic process 2
                        stress-induced homeostatically regulated protein degradation pathway 0
                        transcription factor catabolic process + 2
                        ubiquitin-dependent ERAD pathway + 67
                        ubiquitin-dependent protein catabolic process via the N-end rule pathway 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.