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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


show annotations for term's descendants           Sort by:
 
neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NGFR nerve growth factor receptor ISO RGD PMID:18596692 RGD:5508745 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,357
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,300...191,925,353
JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,438,017...62,485,537
JBrowse link
G FSTL4 follistatin like 4 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:135,486,885...136,096,939
Ensembl chr 2:135,488,545...136,096,788
JBrowse link
G HAP1 huntingtin associated protein 1 enables ISO PMID:21357693
PMID:19996106
UniProt PMID:19996106 PMID:21357693 RGD:10047154 RGD:10047187 NCBI chr12:20,938,463...20,950,053
Ensembl chr12:20,939,554...20,950,051
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables IBA
ISO
IEA
(PMID:21873635) GO_Central
RGD
Ensembl
PMID:16477614 PMID:16983663 PMID:21873635 GO_REF:0000107 RGD:1626130 RGD:1626131 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,438,017...62,485,537
JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme enables IEA Ensembl GO_REF:0000107 NCBI chr 7:53,455,634...53,472,791
Ensembl chr 7:53,460,017...53,472,790
JBrowse link
G NGFR nerve growth factor receptor enables IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:3027580 PMID:21873635 RGD:728964 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,357
JBrowse link
G NTF3 neurotrophin 3 ISO RGD PMID:2164684 RGD:729140 NCBI chr 5:65,052,608...65,122,645
Ensembl chr 5:65,052,517...65,123,788
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 enables
NOT|enables
IEA
ISO
(PMID:15488758) Ensembl
UniProt
RGD
PMID:9753156 PMID:15488758 GO_REF:0000107 RGD:5508802 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G PCSK6 proprotein convertase subtilisin/kexin type 6 enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chr 1:145,508,658...145,697,017
Ensembl chr 1:145,508,636...145,697,009
JBrowse link
G SORT1 sortilin 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:110,721,110...110,791,406
Ensembl chr 4:110,720,100...110,789,702
JBrowse link

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  molecular_function 17452
    binding 15362
      protein binding 13741
        growth factor binding 143
          neurotrophin binding 11
            brain-derived neurotrophic factor binding 4
            nerve growth factor binding 7
paths to the root