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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


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neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) enables ISO MGI
RGD
PMID:18596692 GO_REF:0000096 MGI:4417868 RGD:5508745 NCBI chr11:95,568,818...95,587,698
Ensembl chr11:95,568,818...95,587,735
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 enables IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 3:87,778,244...87,795,242
Ensembl chr 3:87,778,244...87,795,162
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 enables ISO
IDA
IBA
(MGI:893826|PMID:1645620)
(MGI:6201960|PMID:21873635)
MGI
UniProt
GO_Central
PMID:1645620 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:4834177 MGI:6201960 MGI:893826 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 enables IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:78,179,986...78,581,034
Ensembl chr 7:78,175,959...78,738,012
JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin enables ISO MGI
RGD
PMID:11813239 GO_REF:0000096 MGI:4417868 RGD:10046023 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G Fstl4 follistatin-like 4 enables IDA (MGI:5566541|PMID:24573299) MGI PMID:24573299 MGI:5566541 NCBI chr11:52,764,489...53,192,450
Ensembl chr11:52,764,634...53,188,538
JBrowse link
G Hap1 huntingtin-associated protein 1 enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr11:100,347,327...100,356,982
Ensembl chr11:100,347,327...100,356,128
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 enables ISO
IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:893826|PMID:1645620)
MGI
RGD
GO_Central
UniProt
PMID:1645620 PMID:16477614 PMID:16983663 PMID:21873635 GO_REF:0000096 MGI:4417868 MGI:6201960 MGI:893826 RGD:1626130 RGD:1626131 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Pzp PZP, alpha-2-macroglobulin like enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 6:128,483,567...128,526,720
Ensembl chr 6:128,483,567...128,526,720
JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin enables ISO MGI
RGD
PMID:11813239 GO_REF:0000096 MGI:4417868 RGD:10046023 NCBI chr 6:121,636,165...121,679,238
Ensembl chr 6:121,635,376...121,679,227
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) enables ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:80,389,194...80,405,441
Ensembl chr 7:80,388,585...80,405,436
JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) enables ISO
IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:1098517|PMID:1317267)
MGI
RGD
GO_Central
PMID:1317267 PMID:3027580 PMID:21873635 GO_REF:0000096 MGI:1098517 MGI:4417868 MGI:6201960 RGD:728964 NCBI chr11:95,568,818...95,587,698
Ensembl chr11:95,568,818...95,587,735
JBrowse link
G Nradd neurotrophin receptor associated death domain enables IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:110,621,135...110,624,393
Ensembl chr 9:110,621,135...110,624,452
JBrowse link
G Ntf3 neurotrophin 3 enables ISO MGI
RGD
PMID:2164684 GO_REF:0000096 MGI:4417868 RGD:729140 NCBI chr 6:126,101,412...126,166,772
Ensembl chr 6:126,101,412...126,166,910
JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 NOT|enables ISO (PMID:15488758) UniProt
MGI
RGD
PMID:9753156 PMID:15488758 GO_REF:0000096 MGI:4417868 MGI:4834177 RGD:5508802 NCBI chr 3:87,778,244...87,795,242
Ensembl chr 3:87,778,244...87,795,162
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 enables ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 7:65,862,136...66,050,386
Ensembl chr 7:65,861,734...66,050,386
JBrowse link
G Pzp PZP, alpha-2-macroglobulin like enables ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 6:128,483,567...128,526,720
Ensembl chr 6:128,483,567...128,526,720
JBrowse link
G Sort1 sortilin 1 enables ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 3:108,283,974...108,361,519
Ensembl chr 3:108,284,082...108,361,511
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 23082
    binding 16728
      protein binding 14451
        growth factor binding 153
          neurotrophin binding 13
            brain-derived neurotrophic factor binding 5
            nerve growth factor binding 9
paths to the root