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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


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neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NGFR nerve growth factor receptor enables ISS
ISO
UniProt
RGD
PMID:18596692 GO_REF:0000024 RGD:5508745 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,640...156,881,850
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables IBA
ISS
IDA
(PMID:21873635)
(PMID:11738045)
GO_Central
UniProt
PMID:11738045 PMID:21873635 GO_REF:0000024 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,070
Ensembl chr 9:84,668,551...85,027,070
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:87,859,749...88,256,796
Ensembl chr15:87,859,751...88,256,768
JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
JBrowse link
G FSTL4 follistatin like 4 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:133,194,827...133,842,066
Ensembl chr 5:133,196,455...133,612,541
JBrowse link
G HAP1 huntingtin associated protein 1 enables ISS UniProt GO_REF:0000024 NCBI chr17:41,717,739...41,734,646
Ensembl chr17:41,717,742...41,734,644
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables IBA
ISO
ISS
(PMID:21873635) GO_Central
RGD
UniProt
PMID:16477614 PMID:16983663 PMID:21873635 GO_REF:0000024 RGD:1626130 RGD:1626131 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,070
Ensembl chr 9:84,668,551...85,027,070
JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229
JBrowse link
G FURIN furin, paired basic amino acid cleaving enzyme enables IDA (PMID:8615794) BHF-UCL PMID:8615794 NCBI chr15:90,868,588...90,883,457
Ensembl chr15:90,868,588...90,883,458
Ensembl chr15:90,868,588...90,883,458
JBrowse link
G NGFR nerve growth factor receptor enables IBA
ISO
ISS
(PMID:21873635) GO_Central
RGD
UniProt
PMID:3027580 PMID:21873635 GO_REF:0000024 RGD:728964 NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
JBrowse link
G NTF3 neurotrophin 3 ISO RGD PMID:2164684 RGD:729140 NCBI chr12:5,432,108...5,495,299
Ensembl chr12:5,432,108...5,521,536
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 NOT|enables IDA
ISO
(PMID:15488758)
(PMID:1281417), (PMID:15488758), (PMID:17196528)
UniProt
RGD
PMID:1281417 PMID:9753156 PMID:15488758 PMID:17196528 RGD:5508802 NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,640...156,881,850
JBrowse link
G PCSK6 proprotein convertase subtilisin/kexin type 6 enables IDA (PMID:8615794) BHF-UCL PMID:8615794 NCBI chr15:101,303,933...101,489,707
Ensembl chr15:101,297,142...101,525,202
Ensembl chr15:101,297,142...101,525,202
JBrowse link
G SORT1 sortilin 1 enables IPI (PMID:14985763) BHF-UCL PMID:14985763 NCBI chr 1:109,309,575...109,397,940
Ensembl chr 1:109,309,568...109,397,918
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 18814
    binding 17164
      protein binding 15076
        growth factor binding 154
          neurotrophin binding 11
            brain-derived neurotrophic factor binding 4
            nerve growth factor binding 7
paths to the root