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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


show annotations for term's descendants           Sort by:
 
neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NGFR nerve growth factor receptor ISO RGD PMID:18596692 RGD:5508745 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032
JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024
JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSTL4 follistatin like 4 enables IEA Ensembl GO_REF:0000107 NCBI chr11:21,453,982...21,850,969
Ensembl chr11:21,458,678...21,856,547
JBrowse link
G HAP1 huntingtin associated protein 1 enables ISO PMID:19996106
PMID:21357693
UniProt PMID:19996106 PMID:21357693 RGD:10047154 RGD:10047187 NCBI chr 9:21,065,770...21,074,462
Ensembl chr 9:21,065,846...21,072,991
JBrowse link
G LOC477699 alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chr27:36,654,328...36,695,775 JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables IBA
ISO
IEA
(PMID:21873635) GO_Central
RGD
Ensembl
PMID:16477614 PMID:16983663 PMID:21873635 GO_REF:0000107 RGD:1626130 RGD:1626131 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032
JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme enables IEA Ensembl GO_REF:0000107 NCBI chr 3:53,357,491...53,368,285
Ensembl chr 3:53,358,045...53,365,423
JBrowse link
G LOC477699 alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chr27:36,654,328...36,695,775 JBrowse link
G LOC609235 death domain-containing membrane protein NRADD-like enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:41,803,392...41,806,664
Ensembl chr20:41,803,702...41,827,587
JBrowse link
G NGFR nerve growth factor receptor enables IEA
ISO
Ensembl
RGD
PMID:3027580 GO_REF:0000107 RGD:728964 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274
JBrowse link
G NTF3 neurotrophin 3 ISO RGD PMID:2164684 RGD:729140 NCBI chr27:39,383,017...39,454,613
Ensembl chr27:39,383,152...39,454,601
JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 enables
NOT|enables
IEA
ISO
(PMID:15488758) Ensembl
RGD
UniProt
PMID:9753156 PMID:15488758 GO_REF:0000107 RGD:5508802 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288
JBrowse link
G PCSK6 proprotein convertase subtilisin/kexin type 6 enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chr 3:39,582,804...39,768,838
Ensembl chr 3:39,582,819...39,767,929
JBrowse link
G SORT1 sortilin 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:42,454,091...42,521,251
Ensembl chr 6:42,453,942...42,516,740
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  molecular_function 17079
    binding 15370
      protein binding 13839
        growth factor binding 144
          neurotrophin binding 12
            brain-derived neurotrophic factor binding 4
            nerve growth factor binding 8
paths to the root