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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


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neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngfr nerve growth factor receptor ISO RGD PMID:18596692 RGD:5508745 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 enables ISO (PMID:11738045)
(MGI:893826|PMID:1645620)
UniProt PMID:1645620 PMID:11738045 MGI:893826 RGD:8554777 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878
JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fstl4 follistatin like 4 enables ISO (MGI:5566541|PMID:24573299) MGI PMID:24573299 MGI:5566541 NCBI chrNW_004955408:4,521,922...4,898,697
Ensembl chrNW_004955408:4,522,031...4,898,690
JBrowse link
G LOC102021956 alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 enables ISO (MGI:893826|PMID:1645620) RGD
UniProt
PMID:1645620 PMID:16477614 PMID:16983663 MGI:893826 RGD:1626130 RGD:1626131 RGD:8554777 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878
JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Furin furin, paired basic amino acid cleaving enzyme enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chrNW_004955416:14,915,031...14,947,634
Ensembl chrNW_004955416:14,936,546...14,949,252
JBrowse link
G LOC102021956 alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G Ngfr nerve growth factor receptor enables ISO (MGI:1098517|PMID:1317267) RGD
MGI
PMID:1317267 PMID:3027580 MGI:1098517 RGD:728964 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
JBrowse link
G Ntf3 neurotrophin 3 ISO RGD PMID:2164684 RGD:729140 NCBI chrNW_004955413:3,207,669...3,273,371
Ensembl chrNW_004955413:3,207,123...3,273,491
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 NOT|enables ISO (PMID:15488758)
(PMID:1281417), (PMID:15488758), (PMID:17196528)
RGD
UniProt
PMID:1281417 PMID:9753156 PMID:15488758 PMID:17196528 RGD:5508802 NCBI chrNW_004955545:2,929,704...2,947,579
Ensembl chrNW_004955545:2,929,704...2,947,579
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chrNW_004955416:28,184,768...28,314,697
Ensembl chrNW_004955416:28,184,768...28,314,759
JBrowse link
G Sort1 sortilin 1 enables ISO (PMID:14985763) BHF-UCL PMID:14985763 NCBI chrNW_004955435:12,725,952...12,819,280
Ensembl chrNW_004955435:12,730,270...12,819,029
JBrowse link

Term paths to the root
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  molecular_function 13913
    binding 13201
      protein binding 12817
        growth factor binding 114
          neurotrophin binding 9
            brain-derived neurotrophic factor binding 3
            nerve growth factor binding 7
paths to the root