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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405

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neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NGFR nerve growth factor receptor ISO RGD PMID:18596692 RGD:5508745 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables ISO (PMID:11738045)
(MGI:893826|PMID:1645620)		 UniProt PMID:1645620 PMID:11738045 MGI:893826 RGD:8554777 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSTL4 follistatin like 4 enables ISO (MGI:5566541|PMID:24573299) MGI PMID:24573299 MGI:5566541 NCBI chr 5:128,606,171...129,016,734
Ensembl chr 5:134,766,944...135,163,711 		JBrowse link
G HAP1 huntingtin associated protein 1 enables ISO PMID:21357693
PMID:19996106		 UniProt PMID:19996106 PMID:21357693 RGD:10047154 RGD:10047187 NCBI chr17:15,578,658...15,596,313
Ensembl chr17:15,797,949...15,810,299 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 enables ISO (MGI:893826|PMID:1645620) RGD
UniProt		 PMID:1645620 PMID:16477614 PMID:16983663 MGI:893826 RGD:1626130 RGD:1626131 RGD:8554777 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FURIN furin, paired basic amino acid cleaving enzyme enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chr15:69,560,774...69,576,007
Ensembl chr15:88,763,269...88,774,023 		JBrowse link
G NGFR nerve growth factor receptor enables ISO (MGI:1098517|PMID:1317267) RGD
MGI		 PMID:1317267 PMID:3027580 MGI:1098517 RGD:728964 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G NTF3 neurotrophin 3 ISO RGD PMID:2164684 RGD:729140 NCBI chr12:5,551,734...5,615,981
Ensembl chr12:5,530,508...5,533,989 		JBrowse link
G PCSK6 proprotein convertase subtilisin/kexin type 6 enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chr15:80,029,225...80,226,027
Ensembl chr15:99,312,512...99,460,444 		JBrowse link
G SORT1 sortilin 1 enables ISO (PMID:14985763) BHF-UCL PMID:14985763 NCBI chr 1:111,687,119...111,775,339 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 14976
    binding 14174
      protein binding 13735
        growth factor binding 122
          neurotrophin binding 8
            brain-derived neurotrophic factor binding 3
            nerve growth factor binding 5
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