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ONTOLOGY REPORT - ANNOTATIONS


Term:neurotrophin binding
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Accession:GO:0043121 term browser browse the term
Definition:Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.
Comment:Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858].
Synonyms:exact_synonym: neurotrophic factor binding
 narrow_synonym: NT-3 binding;   NT-4 binding;   NT-4/5 binding;   NT-5 binding;   NT3 binding;   NT4 binding;   NT5 binding;   neurotrophin 3 binding;   neurotrophin 4/5 binding
 related_synonym: neurotrophin TRK receptor activity;   neurotrophin TRKA receptor activity;   neurotrophin TRKB receptor activity;   neurotrophin TRKC receptor activity
 alt_id: GO:0048404;   GO:0048405


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neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngfr nerve growth factor receptor IPI RGD PMID:18596692 RGD:5508745 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IDA
IBA
ISO
ISS
PMID:1645620
PMID:21873635
(MGI:893826|PMID:1645620)
GO_REF:0000024
(PMID:11738045)
RGD
UniProt
PMID:1645620 PMID:11738045, PMID:1645620, PMID:21873635 GO_REF:0000024 MGI:893826, RGD:8554777, RGD:13792537 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IDA RGD PMID:11813239 RGD:10046023 NCBI chr 4:154,309,426...154,359,138 JBrowse link
G Fstl4 follistatin-like 4 ISO (MGI:5566541|PMID:24573299) RGD PMID:24573299 MGI:5566541 NCBI chr10:38,104,344...38,532,216
Ensembl chr10:38,104,558...38,532,196
JBrowse link
G Hap1 huntingtin-associated protein 1 IDA PMID:19996106
PMID:21357693
UniProt PMID:19996106, PMID:21357693 RGD:10047154, RGD:10047187 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IMP
IBA
ISO
IEA
IDA
PMID:21873635
(MGI:893826|PMID:1645620)
GO_REF:0000107
RGD
Ensembl
PMID:1645620, PMID:16983663, PMID:21873635, PMID:1645620, PMID:16477614 GO_REF:0000107 MGI:893826, RGD:1626130, RGD:13792537, RGD:8554777, RGD:1626131 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Pzp pregnancy-zone protein IDA RGD PMID:11813239 RGD:10046023 NCBI chr 4:161,804,792...161,850,877
Ensembl chr 4:161,804,784...161,850,875
JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IDA RGD PMID:11813239 RGD:10046023 NCBI chr 4:154,309,426...154,359,138 JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO
IEA
(PMID:8615794)
GO_REF:0000107
RGD
Ensembl
PMID:8615794 GO_REF:0000107 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G Ngfr nerve growth factor receptor IDA
IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:1098517|PMID:1317267)
Ensembl
RGD
PMID:1317267, PMID:3027580, PMID:21873635 GO_REF:0000107 MGI:1098517, RGD:728964, RGD:13792537 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nradd neurotrophin receptor associated death domain IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:118,890,402...118,893,712
Ensembl chr 8:118,890,399...118,893,702
JBrowse link
G Ntf3 neurotrophin 3 IMP RGD PMID:2164684 RGD:729140 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 NOT IDA
ISO
ISS
(PMID:1281417), (PMID:15488758), (PMID:17196528)
GO_REF:0000024
(PMID:15488758)
RGD
UniProt
PMID:1281417 PMID:15488758 PMID:17196528, PMID:9753156 GO_REF:0000024, RGD:5508802 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 ISO (PMID:8615794) RGD PMID:8615794 NCBI chr 1:126,749,508...126,947,392
Ensembl chr 1:126,749,508...126,947,392
JBrowse link
G Pzp pregnancy-zone protein IDA RGD PMID:11813239 RGD:10046023 NCBI chr 4:161,804,792...161,850,877
Ensembl chr 4:161,804,784...161,850,875
JBrowse link
G Sort1 sortilin 1 ISO UniProtKB:P01138 (PMID:14985763) RGD PMID:14985763 NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20486
    binding 17290
      protein binding 14416
        growth factor binding 148
          neurotrophin binding 13
            brain-derived neurotrophic factor binding 5
            nerve growth factor binding 9
paths to the root