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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of vascular permeability
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Accession:GO:0043114 term browser browse the term
Definition:Any process that modulates the extent to which blood vessels can be pervaded by fluid.


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regulation of vascular permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABR ABR activator of RhoGEF and GTPase involved_in ISO (MGI:5475443|PMID:23152932) CACAO PMID:23152932 MGI:5475443 NCBI chr 9:44,634,117...44,821,454
Ensembl chr 9:44,681,411...44,819,249 		JBrowse link
G BCR BCR activator of RhoGEF and GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:27,856,280...27,980,923
Ensembl chr26:27,856,082...27,978,318 		JBrowse link
G CDH5 cadherin 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:82,830,505...82,863,931
Ensembl chr 5:82,830,939...82,863,882 		JBrowse link
G GPR4 G protein-coupled receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,963,001...109,974,798 JBrowse link
G HRH1 histamine receptor H1 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr20:7,160,903...7,236,147
Ensembl chr20:7,162,393...7,235,869 		JBrowse link
G PLEC plectin involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:37,449,379...37,503,752
Ensembl chr13:37,450,248...37,513,523 		JBrowse link
G PLVAP plasmalemma vesicle associated protein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:45,405,295...45,417,093
Ensembl chr20:45,351,091...45,416,477 		JBrowse link
negative regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO RGD PMID:18854840 RGD:2325137 NCBI chr21:39,963,001...40,037,040
Ensembl chr21:39,962,947...40,036,981 		JBrowse link
G SH3GL2 SH3 domain containing GRB2 like 2, endophilin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:37,720,793...37,769,027
Ensembl chr11:37,577,053...37,767,572 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
negative regulation of lipid transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:24345162) Alzheimers_University_of_Toronto PMID:24345162 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
negative regulation of vascular permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495 		JBrowse link
G ADORA2A adenosine A2a receptor ISO RGD PMID:16815983 RGD:1625437 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598 		JBrowse link
G AKAP12 A-kinase anchoring protein 12 ISO RGD PMID:20454828 RGD:14348957 NCBI chr 1:41,614,893...41,712,350
Ensembl chr 1:41,614,714...41,709,798 		JBrowse link
G AMOT angiomotin involved_in ISO (PMID:16043488) UniProt PMID:16043488 NCBI chr  X:85,742,610...85,807,557
Ensembl chr  X:85,745,207...85,807,353 		JBrowse link
G ANGPT1 angiopoietin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1351100|PMID:10617467), (MGI:3722538|PMID:17562701) MGI
Ensembl
Ensembl		 PMID:10617467 PMID:17562701 GO_REF:0000107 MGI:1351100 MGI:3722538 NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618 		JBrowse link
G ARHGAP35 Rho GTPase activating protein 35 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3722538|PMID:17562701) Ensembl
Ensembl
MGI		 PMID:17562701 GO_REF:0000107 MGI:3722538 NCBI chr 1:108,952,836...109,034,329
Ensembl chr 1:108,952,562...109,034,337 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:5317069|PMID:21081647) UniProt PMID:21081647 MGI:5317069 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830 		JBrowse link
G CLDN5 claudin 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr26:29,702,464...29,704,950
Ensembl chr26:29,703,683...29,704,339 		JBrowse link
G DDAH1 dimethylarginine dimethylaminohydrolase 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:62,548,852...62,683,687
Ensembl chr 6:62,549,152...62,683,729 		JBrowse link
G FERMT2 FERM domain containing kindlin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:29,083,538...29,135,915
Ensembl chr 8:29,084,531...29,133,391 		JBrowse link
G MIR23A microRNA mir-23a involved_in ISO (PMID:27741223) BHF-UCL PMID:27741223 NCBI chr20:48,620,335...48,620,386
Ensembl chr20:48,620,323...48,620,397 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 ISO RGD PMID:7648494 RGD:4892565 NCBI chr 2:38,124,568...38,242,510
Ensembl chr 2:38,123,190...38,240,755 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr21:25,542,030...25,635,661
Ensembl chr21:25,542,268...25,635,660 		JBrowse link
G PDE3A phosphodiesterase 3A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr27:26,555,558...26,878,624
Ensembl chr27:26,560,547...26,878,913 		JBrowse link
G PTPRJ protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:41,586,262...41,635,386
Ensembl chr18:41,586,112...41,635,308 		JBrowse link
G RAMP2 receptor activity modifying protein 2 involved_in ISO (PMID:18097473)
(MGI:3772552|PMID:18097473)		 UniProt PMID:18097473 MGI:3772552 NCBI chr 9:20,250,711...20,252,485 JBrowse link
G SLIT2 slit guidance ligand 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:88,964,707...89,311,817
Ensembl chr 3:88,966,232...89,312,955 		JBrowse link
G TJP1 tight junction protein 1 ISO RGD PMID:20137299 RGD:2325126 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
G VPS25 vacuolar protein sorting 25 homolog involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:20,242,230...20,247,396 JBrowse link
positive regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANGPT1 angiopoietin 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:8,068,920...8,312,090
Ensembl chr13:8,048,205...8,311,618 		JBrowse link
G OCLN occludin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430 		JBrowse link
G TJP1 tight junction protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
G TJP2 tight junction protein 2 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 1:88,126,134...88,251,018
Ensembl chr 1:88,126,136...88,230,654 		JBrowse link
G TJP3 tight junction protein 3 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr20:55,720,632...55,746,776
Ensembl chr20:55,720,632...55,746,965 		JBrowse link
positive regulation of lipid transport across blood-brain barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
positive regulation of vascular permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 involved_in ISO (PMID:21168935) UniProt PMID:21168935 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G BMP6 bone morphogenetic protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr35:7,780,763...7,833,095
Ensembl chr35:7,804,231...7,831,845 		JBrowse link
G CAPN1 calpain 1 ISO RGD PMID:21415394 RGD:13792556 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757 		JBrowse link
G CCL4 chemokine (C-C motif) ligand 4 ISO RGD PMID:10679105 RGD:68880 NCBI chr 9:37,681,342...37,682,691
Ensembl chr 9:37,676,966...37,710,209 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO RGD PMID:19255141 RGD:7257695 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247 		JBrowse link
G FGFBP3 fibroblast growth factor binding protein 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18669637) MGI
Ensembl
Ensembl		 PMID:18669637 GO_REF:0000107 NCBI chr28:6,398,604...6,402,008
Ensembl chr28:6,400,234...6,401,013 		JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 involved_in ISO (PMID:17311300) AgBase PMID:17311300 NCBI chr25:11,231,958...11,410,379
Ensembl chr25:11,231,737...11,407,621 		JBrowse link
G IL18 interleukin 18 ISO RGD PMID:11739527 RGD:729357 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr21:25,542,030...25,635,661
Ensembl chr21:25,542,268...25,635,660 		JBrowse link
G PDE3A phosphodiesterase 3A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr27:26,555,558...26,878,624
Ensembl chr27:26,560,547...26,878,913 		JBrowse link
G PTP4A3 protein tyrosine phosphatase 4A3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5568017|PMID:24403062) MGI
Ensembl
Ensembl		 PMID:24403062 GO_REF:0000107 MGI:5568017 NCBI chr13:35,875,467...35,886,330
Ensembl chr13:35,880,005...35,886,324 		JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:18326823 RGD:2304321 NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971 		JBrowse link
G TACR2 tachykinin receptor 2 ISO RGD PMID:9374705 RGD:5147484 NCBI chr 4:20,518,797...20,531,118
Ensembl chr 4:20,517,563...20,531,867 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 involved_in IMP
IEA		 (PMID:23136043) UniProt
Ensembl		 PMID:23136043 GO_REF:0000107 NCBI chr26:17,293,334...17,330,156
Ensembl chr26:17,262,100...17,330,165 		JBrowse link
G UCN urocortin ISO RGD PMID:19819946 RGD:5508179 NCBI chr17:21,278,512...21,280,404
Ensembl chr17:21,278,932...21,279,312 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:1351100|PMID:10617467), (MGI:5568017|PMID:24403062) RGD
Ensembl
MGI		 PMID:10617467 PMID:16793871 PMID:24403062 GO_REF:0000107 MGI:1351100 MGI:5568017 RGD:1580547 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
G VEGFB vascular endothelial growth factor B NOT|involved_in ISO (PMID:16109918) UniProt PMID:16109918 NCBI chr18:52,821,348...52,824,649
Ensembl chr18:52,821,365...52,824,655 		JBrowse link
regulation of blood-brain barrier permeability term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZEB2 zinc finger E-box binding homeobox 2 ISO RGD PMID:34334113 RGD:155882538 NCBI chr19:46,419,812...46,541,888
Ensembl chr19:46,423,998...46,542,122 		JBrowse link
regulation of vascular permeability involved in acute inflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C2CD4A C2 calcium dependent domain containing 4A involved_in ISO (PMID:15527968) UniProt PMID:15527968 NCBI chr30:26,783,282...26,787,016 JBrowse link
G LOC100688626 uncharacterized LOC100688626 involved_in ISO (PMID:15527968) UniProt PMID:15527968 NCBI chr30:26,865,346...26,875,141 JBrowse link
G LOC479600 beta-catenin-interacting protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:62,937,154...63,093,083
Ensembl chr 5:62,938,511...63,093,275 		JBrowse link
G MYLK3 myosin light chain kinase 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:8,382,436...8,416,740
Ensembl chr15:8,381,854...8,416,368 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17438
    biological regulation 12384
      regulation of biological quality 3129
        regulation of vascular permeability 52
          negative regulation of vascular permeability + 23
          positive regulation of vascular permeability + 23
          regulation of blood-brain barrier permeability + 9
          regulation of lymphatic vascular permeability 0
          regulation of transport across blood-brain barrier + 1
          regulation of vascular permeability involved in acute inflammatory response 4
Path 2
Term Annotations click to browse term
  biological_process 17438
    multicellular organismal process 8261
      system process 2855
        circulatory system process 592
          vascular process in circulatory system 253
            regulation of vascular permeability 52
              negative regulation of vascular permeability + 23
              positive regulation of vascular permeability + 23
              regulation of blood-brain barrier permeability + 9
              regulation of lymphatic vascular permeability 0
              regulation of transport across blood-brain barrier + 1
              regulation of vascular permeability involved in acute inflammatory response 4
paths to the root