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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of catalytic activity
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Accession:GO:0043086 term browser browse the term
Definition:Any process that stops or reduces the activity of an enzyme.
Synonyms:exact_synonym: down regulation of enzyme activity;   downregulation of enzyme activity;   negative regulation of enzyme activity
 narrow_synonym: down regulation of metalloenzyme activity;   downregulation of metalloenzyme activity;   inhibition of enzyme activity;   inhibition of metalloenzyme activity;   negative regulation of metalloenzyme activity
 alt_id: GO:0048553


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negative regulation of catalytic activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAST calpastatin ISO RGD PMID:17429681 RGD:1626249 NCBI chr 2:103,255,738...103,378,623
Ensembl chr 2:103,255,750...103,378,623 		JBrowse link
G HNRNPR heterogeneous nuclear ribonucleoprotein R ISO arylalkylamine N-acetyltransferase activity RGD PMID:15798208 RGD:9854643 NCBI chr 6:81,203,067...81,239,823
Ensembl chr 6:81,196,062...81,239,406 		JBrowse link
G RENBP renin binding protein ISO RGD PMID:11726282 RGD:5132613 NCBI chr  X:124,662,957...124,670,522
Ensembl chr  X:124,662,719...124,672,235 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP5 A-kinase anchoring protein 5 ISO RGD PMID:20410303 RGD:7242424 NCBI chr 7:88,538,938...88,544,330
Ensembl chr 7:88,538,984...88,547,392 		JBrowse link
G AKAP6 A-kinase anchoring protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chr 7:66,913,541...67,462,147
Ensembl chr 7:66,915,881...67,375,177 		JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chr 9:71,895,615...72,054,898
Ensembl chr 9:71,895,635...72,054,897 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chr 7:22,547,938...22,577,639
Ensembl chr 7:22,540,381...22,578,619 		JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chr17:61,622,865...61,627,278
Ensembl chr17:61,622,938...61,627,278 		JBrowse link
G NPR3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chr16:18,841,540...18,929,813
Ensembl chr16:18,842,039...18,929,805 		JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943 		JBrowse link
negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO RGD PMID:12810716 RGD:632260 NCBI chr 2:5,042,883...5,048,885
Ensembl chr 2:5,041,990...5,048,781 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:22975349 RGD:8554232 NCBI chr14:59,113,527...59,168,421
Ensembl chr14:59,113,844...59,168,395 		JBrowse link
G RGN regucalcin ISO RGD PMID:1656206 RGD:9590243 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 ISO RGD PMID:10721722 RGD:632478 NCBI chr 1:260,465,809...260,648,070
Ensembl chr 1:260,466,942...260,648,161 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 ISO RGD PMID:10721722 RGD:632478 NCBI chr12:24,224,262...24,234,468
Ensembl chr12:24,224,263...24,234,467 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO RGD PMID:22584582 RGD:10045364 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G HTT huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chr 8:1,809,768...1,934,002
Ensembl chr 8:1,809,785...1,934,024 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G EP300 E1A binding protein p300 ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G GPI glucose-6-phosphate isomerase ISO RGD PMID:12615053 RGD:1600634 NCBI chr 6:44,038,374...44,069,331
Ensembl chr 6:44,038,357...44,069,328 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chr 6:18,901,171...18,913,427
Ensembl chr 6:18,901,297...18,913,424 		JBrowse link
G HNF1A HNF1 homeobox A ISO RGD PMID:21874357 RGD:150540304 NCBI chr14:40,868,819...40,888,322
Ensembl chr14:40,868,676...40,888,328 		JBrowse link
G IL6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G MDM2 MDM2 proto-oncogene ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr 3:10,212,734...10,272,184
Ensembl chr 3:10,212,735...10,281,823 		JBrowse link
G PTMA prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435 		JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:19240864 RGD:7411612 NCBI chr 5:62,406,928...62,483,690
Ensembl chr 5:62,440,810...62,483,678 		JBrowse link
G RENBP renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chr  X:124,662,957...124,670,522
Ensembl chr  X:124,662,719...124,672,235 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:10717410 RGD:8547889 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547 		JBrowse link
negative regulation of GTP cyclohydrolase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCHFR GTP cyclohydrolase I feedback regulator ISO RGD PMID:8702680 RGD:728623 NCBI chr 1:130,559,223...130,563,598
Ensembl chr 1:130,554,978...130,559,597 		JBrowse link
negative regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:15870074 RGD:2325307 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294 		JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:1517224 RGD:631708 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,516,947...9,597,976 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:1517224 RGD:631708 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293 		JBrowse link
G PTPRN2 protein tyrosine phosphatase receptor type N2 ISO RGD PMID:16413169 RGD:1625628 NCBI chr18:721,125...1,389,609
Ensembl chr18:721,131...1,389,607 		JBrowse link
G RGN regucalcin ISO RGD PMID:11510494 RGD:9590205 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
G TSC1 TSC complex subunit 1 ISO RGD PMID:15611338 RGD:1601406 NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,951 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 6:89,187,544...89,197,049
Ensembl chr 6:89,188,133...89,197,045 		JBrowse link
negative regulation of hexokinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCKR glucokinase regulator ISO RGD PMID:14627435 RGD:1598592 NCBI chr 3:111,649,557...111,683,539
Ensembl chr 3:111,649,539...111,676,772 		JBrowse link
negative regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCZ protein kinase C zeta ISO inhibition of acid sphingomyelinase translocation to cell surface and activation RGD PMID:17346242 RGD:1642658 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr 2:16,562,687...16,584,763
Ensembl chr 2:16,564,257...16,584,768 		JBrowse link
negative regulation of kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSK C-terminal Src kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chr 7:58,736,473...58,755,034
Ensembl chr 7:58,736,531...58,755,260 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 ISO RGD PMID:19762078 RGD:150429972 NCBI chr 4:87,749,738...87,911,818
Ensembl chr 4:87,756,168...87,911,296 		JBrowse link
G PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 ISO RGD PMID:9366267 RGD:5134981 NCBI chr12:5,141,223...5,174,383
Ensembl chr12:5,144,069...5,174,382 		JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 ISO due to an autoinhibitory domain RGD PMID:15081430 RGD:2298791 NCBI chr 5:68,000,792...68,142,533
Ensembl chr 5:68,000,905...68,140,755 		JBrowse link
negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:2280766 RGD:9590217 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
negative regulation of lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 ISO RGD PMID:10419291 RGD:1626385 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO phospholipase D RGD PMID:18801337 RGD:4889814 NCBI chr 3:10,212,734...10,272,184
Ensembl chr 3:10,212,735...10,281,823 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr 9:6,793,971...6,807,286
Ensembl chr 9:6,793,069...6,808,028 		JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr 2:40,458,865...40,521,470
Ensembl chr 2:40,459,049...40,521,461 		JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,925...39,937,371 		JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPRIP myosin phosphatase Rho interacting protein ISO RGD PMID:17661354 RGD:9685557 NCBI chr12:61,077,617...61,185,906
Ensembl chr12:61,077,628...61,186,129 		JBrowse link
negative regulation of NAD(P)H oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL13 interleukin 13 ISO RGD PMID:19752235 RGD:8549634 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
negative regulation of nitric-oxide synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG2 arginase 2 ISO RGD PMID:16537391 RGD:1582129 NCBI chr 7:91,343,987...91,385,911
Ensembl chr 7:91,343,988...91,385,909 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:18561998 RGD:2316219 NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602 		JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:18561998 RGD:2316219 NCBI chr 6:81,659,162...81,692,550
Ensembl chr 6:81,659,169...81,692,550 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:18005341 RGD:10045554 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569 		JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LPIN1 lipin 1 ISO RGD PMID:21715287 RGD:38599010 NCBI chr 3:124,940,557...125,074,137
Ensembl chr 3:124,940,561...125,074,122 		JBrowse link
negative regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:2969352 RGD:7421659 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279 		JBrowse link
negative regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:11779129 RGD:70605 NCBI chr 1:82,540,998...82,698,652
Ensembl chr 1:82,541,018...82,698,633 		JBrowse link
negative regulation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:9188501 RGD:13506241 NCBI chr 1:82,540,998...82,698,652
Ensembl chr 1:82,541,018...82,698,633 		JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPIA peptidylprolyl isomerase A ISO RGD PMID:19832699 RGD:7247324 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10585469 PMID:12016225 RGD:625568 RGD:9999389 NCBI chr12:26,319,123...26,337,089
Ensembl chr12:26,319,124...26,336,562 		JBrowse link
G RGN regucalcin ISO RGD PMID:10922512 RGD:9590172 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G DAXX death domain associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110 		JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:12688394 RGD:1581394 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,189,602...49,191,976 		JBrowse link
G DRD5 dopamine receptor D5 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 8:6,180,221...6,182,575
Ensembl chr 8:6,180,221...6,181,636 		JBrowse link
G IL6 interleukin 6 ISO Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G ILK integrin linked kinase ISO GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858 		JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO RGD PMID:21668448 RGD:10401931 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G PCP4 Purkinje cell protein 4 ISO RGD PMID:10751438 RGD:1579763 NCBI chr13:203,412,479...203,479,216
Ensembl chr13:203,412,479...203,479,209 		JBrowse link
G RGN regucalcin ISO RGD PMID:11455566 RGD:9590207 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,794 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINA1 serpin family A member 1 ISO RGD PMID:19240864 RGD:7411612 NCBI chr 7:115,604,282...115,616,915
Ensembl chr 7:115,583,043...115,614,645 		JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 ISO RGD PMID:12771515 RGD:724699 NCBI chr 2:149,072,652...149,079,529
Ensembl chr 2:149,071,703...149,079,499 		JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:16556873 RGD:1580657 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    biological regulation 12896
      regulation of molecular function 303
        regulation of catalytic activity 186
          negative regulation of catalytic activity 70
            negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity 0
            negative regulation of cyclase activity + 7
            negative regulation of helicase activity + 0
            negative regulation of hydrolase activity + 37
            negative regulation of ligase activity + 1
            negative regulation of lyase activity + 7
            negative regulation of oxidoreductase activity + 5
            negative regulation of prostaglandin-E synthase activity 0
            negative regulation of transferase activity + 23
paths to the root