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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of catalytic activity
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Accession:GO:0043086 term browser browse the term
Definition:Any process that stops or reduces the activity of an enzyme.
Synonyms:exact_synonym: down regulation of enzyme activity;   downregulation of enzyme activity;   negative regulation of enzyme activity
 narrow_synonym: down regulation of metalloenzyme activity;   downregulation of metalloenzyme activity;   inhibition of enzyme activity;   inhibition of metalloenzyme activity;   negative regulation of metalloenzyme activity
 alt_id: GO:0048553


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negative regulation of catalytic activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cast calpastatin ISO RGD PMID:17429681 RGD:1626249 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R ISO arylalkylamine N-acetyltransferase activity RGD PMID:15798208 RGD:9854643 NCBI chr 4:136,038,230...136,086,758
Ensembl chr 4:136,038,253...136,086,758 		JBrowse link
G Renbp renin binding protein ISO RGD PMID:11726282 RGD:5132613 NCBI chr  X:72,965,727...72,974,408
Ensembl chr  X:72,965,727...72,974,456 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap5 A kinase anchor protein 5 ISO RGD PMID:20410303 RGD:7242424 NCBI chr12:76,371,652...76,380,925
Ensembl chr12:76,371,665...76,380,927 		JBrowse link
G Akap6 A kinase anchor protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chr12:52,745,371...53,202,351
Ensembl chr12:52,746,166...53,202,382 		JBrowse link
G Akap9 A kinase anchor protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chr 5:3,977,410...4,130,204
Ensembl chr 5:3,978,054...4,131,310 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chr17:37,356,888...37,385,197
Ensembl chr17:37,356,858...37,385,959 		JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chr 2:179,741,258...179,746,264
Ensembl chr 2:179,741,258...179,746,281 		JBrowse link
G Npr3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chr15:11,839,982...11,907,287
Ensembl chr15:11,839,982...11,907,373 		JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO RGD PMID:12810716 RGD:632260 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 ISO RGD PMID:22975349 RGD:8554232 NCBI chr 8:125,635,325...125,676,063
Ensembl chr 8:125,635,326...125,676,063 		JBrowse link
G Rgn regucalcin ISO RGD PMID:1656206 RGD:9590243 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO RGD PMID:10721722 RGD:632478 NCBI chr 4:70,135,092...70,328,672
Ensembl chr 4:70,135,093...70,328,680 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 ISO RGD PMID:10721722 RGD:632478 NCBI chr11:96,798,251...96,807,359
Ensembl chr11:96,798,252...96,807,322 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO RGD PMID:22584582 RGD:10045364 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Htt huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Ep300 E1A binding protein p300 ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Gpi1 glucose-6-phosphate isomerase 1 ISO RGD PMID:12615053 RGD:1600634 NCBI chr 7:33,900,752...33,929,761
Ensembl chr 7:33,900,755...33,929,761 		JBrowse link
G Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chr 8:95,113,057...95,121,999
Ensembl chr 8:95,113,066...95,122,005 		JBrowse link
G Hnf1a HNF1 homeobox A ISO RGD PMID:21874357 RGD:150540304 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153 		JBrowse link
G Hspa1b heat shock protein 1B ISO reduced cleavage of Casp8 and Casp9 in brain following hypoxic/ischemic injury RGD PMID:16397188 RGD:1626654 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Por cytochrome p450 oxidoreductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
G Ptma prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434 		JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:19240864 RGD:7411612 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Renbp renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chr  X:72,965,727...72,974,408
Ensembl chr  X:72,965,727...72,974,456 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO RGD PMID:10717410 RGD:8547889 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
negative regulation of GTP cyclohydrolase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gchfr GTP cyclohydrolase I feedback regulator ISO RGD PMID:8702680 RGD:728623 NCBI chr 2:118,998,269...119,002,870
Ensembl chr 2:118,998,254...119,002,871 		JBrowse link
negative regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:15870074 RGD:2325307 NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965 		JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:1517224 RGD:631708 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:1517224 RGD:631708 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Ptprn2 protein tyrosine phosphatase receptor type N polypeptide 2 ISO RGD PMID:16413169 RGD:1625628 NCBI chr12:116,449,316...117,241,787
Ensembl chr12:116,449,340...117,240,469 		JBrowse link
G Rgn regucalcin ISO RGD PMID:11510494 RGD:9590205 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
G Tsc1 TSC complex subunit 1 ISO RGD PMID:15611338 RGD:1601406 NCBI chr 2:28,531,005...28,581,183
Ensembl chr 2:28,531,240...28,581,179 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 4:129,005,363...129,019,712
Ensembl chr 4:129,005,363...129,015,829 		JBrowse link
negative regulation of hexokinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gckr glucokinase regulatory protein ISO RGD PMID:14627435 RGD:1598592 NCBI chr 5:31,454,594...31,484,646
Ensembl chr 5:31,454,787...31,484,658 		JBrowse link
negative regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcz protein kinase C, zeta ISO inhibition of acid sphingomyelinase translocation to cell surface and activation RGD PMID:17346242 RGD:1642658 NCBI chr 4:155,344,579...155,445,856
Ensembl chr 4:155,344,586...155,445,818 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr 2:92,214,021...92,231,608
Ensembl chr 2:92,214,021...92,231,608 		JBrowse link
negative regulation of kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csk c-src tyrosine kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chr 9:57,533,929...57,560,758
Ensembl chr 9:57,533,929...57,560,914 		JBrowse link
G Ddr2 discoidin domain receptor family, member 2 ISO RGD PMID:19762078 RGD:150429972 NCBI chr 1:169,799,874...169,938,525
Ensembl chr 1:169,799,876...169,938,331 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 ISO RGD PMID:9366267 RGD:5134981 NCBI chr11:116,361,641...116,385,739
Ensembl chr11:116,361,671...116,385,461 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO due to an autoinhibitory domain RGD PMID:15081430 RGD:2298791 NCBI chr 6:119,900,930...120,015,659
Ensembl chr 6:119,900,930...120,015,633 		JBrowse link
negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin ISO RGD PMID:2280766 RGD:9590217 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
negative regulation of lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A-I ISO RGD PMID:10419291 RGD:1626385 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Por cytochrome p450 oxidoreductase ISO phospholipase D RGD PMID:18801337 RGD:4889814 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr 7:101,471,839...101,487,419
Ensembl chr 7:101,471,839...101,487,436 		JBrowse link
G Kng2 kininogen 2 ISO in ConA- or PHA-stimulated Jurkat cells RGD PMID:16140359 RGD:1600541 NCBI chr16:22,804,602...22,847,851
Ensembl chr16:22,804,604...22,848,232 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mprip myosin phosphatase Rho interacting protein ISO RGD PMID:17661354 RGD:9685557 NCBI chr11:59,552,973...59,671,686
Ensembl chr11:59,552,131...59,671,686 		JBrowse link
negative regulation of NAD(P)H oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 ISO RGD PMID:19752235 RGD:8549634 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
negative regulation of nitric-oxide synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase type II ISO RGD PMID:16537391 RGD:1582129 NCBI chr12:79,177,562...79,203,075
Ensembl chr12:79,177,551...79,203,075 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:18561998 RGD:2316219 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO RGD PMID:18561998 RGD:2316219 NCBI chr 4:135,622,500...135,647,530
Ensembl chr 4:135,622,705...135,647,518 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:18005341 RGD:10045554 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpin1 lipin 1 ISO RGD PMID:21715287 RGD:38599010 NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967 		JBrowse link
negative regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO RGD PMID:2969352 RGD:7421659 NCBI chr19:20,350,798...20,368,035
Ensembl chr19:20,350,792...20,368,308 		JBrowse link
negative regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snap91 synaptosomal-associated protein 91 ISO RGD PMID:11779129 RGD:70605 NCBI chr 9:86,647,976...86,762,766
Ensembl chr 9:86,647,976...86,762,707 		JBrowse link
negative regulation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snap91 synaptosomal-associated protein 91 ISO RGD PMID:9188501 RGD:13506241 NCBI chr 9:86,647,976...86,762,766
Ensembl chr 9:86,647,976...86,762,707 		JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppia peptidylprolyl isomerase A ISO RGD PMID:19832699 RGD:7247324 NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B ISO RGD PMID:10585469 PMID:12016225 RGD:625568 RGD:9999389 NCBI chr11:94,882,038...94,897,724
Ensembl chr11:94,881,861...94,897,725 		JBrowse link
G Rgn regucalcin ISO RGD PMID:10922512 RGD:9590172 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr10:75,152,711...75,170,626
Ensembl chr10:75,152,711...75,170,618 		JBrowse link
G Daxx Fas death domain-associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:12688394 RGD:1581394 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 ISO RGD PMID:21668448 RGD:10401931 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Il6 interleukin 6 ISO Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ilk integrin linked kinase ISO GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Pcp4 Purkinje cell protein 4 ISO RGD PMID:10751438 RGD:1579763 NCBI chr16:96,268,806...96,326,993
Ensembl chr16:96,268,806...96,326,993 		JBrowse link
G Rgn regucalcin ISO RGD PMID:11455566 RGD:9590207 NCBI chr  X:20,413,980...20,428,328
Ensembl chr  X:20,416,026...20,428,328 		JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO RGD PMID:12771515 RGD:724699 NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622 		JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:16556873 RGD:1580657 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    biological regulation 13118
      regulation of molecular function 307
        regulation of catalytic activity 189
          negative regulation of catalytic activity 71
            negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity 0
            negative regulation of cyclase activity + 7
            negative regulation of helicase activity + 0
            negative regulation of hydrolase activity + 37
            negative regulation of ligase activity + 1
            negative regulation of lyase activity + 7
            negative regulation of oxidoreductase activity + 5
            negative regulation of prostaglandin-E synthase activity 0
            negative regulation of transferase activity + 24
paths to the root