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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of catalytic activity
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Accession:GO:0043086 term browser browse the term
Definition:Any process that stops or reduces the activity of an enzyme.
Synonyms:exact_synonym: down regulation of enzyme activity;   downregulation of enzyme activity;   negative regulation of enzyme activity
 narrow_synonym: down regulation of metalloenzyme activity;   downregulation of metalloenzyme activity;   inhibition of enzyme activity;   inhibition of metalloenzyme activity;   negative regulation of metalloenzyme activity
 alt_id: GO:0048553

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negative regulation of catalytic activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cast calpastatin ISO RGD PMID:17429681 RGD:1626249 NCBI chrNW_004955418:15,859,951...15,974,141
Ensembl chrNW_004955418:15,862,729...15,916,169 		JBrowse link
G Hnrnpr heterogeneous nuclear ribonucleoprotein R ISO arylalkylamine N-acetyltransferase activity RGD PMID:15798208 RGD:9854643 NCBI chrNW_004955452:3,318,536...3,354,725
Ensembl chrNW_004955452:3,315,133...3,355,508 		JBrowse link
G Renbp renin binding protein ISO RGD PMID:11726282 RGD:5132613 NCBI chrNW_004955580:610,112...615,019
Ensembl chrNW_004955580:609,964...615,027 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap5 A-kinase anchoring protein 5 ISO RGD PMID:20410303 RGD:7242424 NCBI chrNW_004955466:5,411,190...5,422,043
Ensembl chrNW_004955466:5,411,650...5,412,960 		JBrowse link
G Akap6 A-kinase anchoring protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chrNW_004955409:28,067,814...28,516,881
Ensembl chrNW_004955409:28,077,621...28,516,944 		JBrowse link
G Akap9 A-kinase anchoring protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chrNW_004955432:8,933,037...9,090,872
Ensembl chrNW_004955432:8,932,952...9,095,065 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chrNW_004955583:85,255...115,140
Ensembl chrNW_004955583:85,255...115,189 		JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chrNW_004955528:1,819,247...1,826,707
Ensembl chrNW_004955528:1,819,247...1,826,707 		JBrowse link
G Npr3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chrNW_004955426:18,491,350...18,559,299
Ensembl chrNW_004955426:18,491,350...18,553,743 		JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chrNW_004955410:20,428,531...20,459,482
Ensembl chrNW_004955410:20,428,546...20,456,836 		JBrowse link
negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl hydrocarbon receptor interacting protein ISO RGD PMID:12810716 RGD:632260 NCBI chrNW_004955422:17,997,683...18,003,888
Ensembl chrNW_004955422:17,997,683...18,004,201 		JBrowse link
G Egln1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:22975349 RGD:8554232 NCBI chrNW_004955492:7,407,800...7,454,851
Ensembl chrNW_004955492:7,407,800...7,454,842 		JBrowse link
G Rgn regucalcin ISO RGD PMID:1656206 RGD:9590243 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO RGD PMID:10721722 RGD:632478 NCBI chrNW_004955419:7,412,177...7,606,883
Ensembl chrNW_004955419:7,412,331...7,610,353 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 ISO RGD PMID:10721722 RGD:632478 NCBI chrNW_004955451:13,160,811...13,170,012
Ensembl chrNW_004955451:13,120,761...13,170,073 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO RGD PMID:22584582 RGD:10045364 NCBI chrNW_004955413:9,615,542...9,620,542
Ensembl chrNW_004955413:9,615,542...9,620,542 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412 		JBrowse link
G Htt huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chrNW_004955514:1,906,189...2,042,357
Ensembl chrNW_004955514:1,906,502...2,038,889 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chrNW_004955578:950,258...1,004,438
Ensembl chrNW_004955578:967,593...1,004,438 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022 		JBrowse link
G Ep300 E1A binding protein p300 ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Gpi glucose-6-phosphate isomerase ISO RGD PMID:12615053 RGD:1600634 NCBI chrNW_004955468:3,980,999...4,007,553
Ensembl chrNW_004955468:3,980,999...4,008,652 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chrNW_004955433:14,609,275...14,621,774
Ensembl chrNW_004955433:14,608,375...14,621,839 		JBrowse link
G Hnf1a HNF1 homeobox A ISO RGD PMID:21874357 RGD:150540304 NCBI chrNW_004955455:10,694,102...10,717,613
Ensembl chrNW_004955455:10,694,102...10,717,613 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Mdm2 MDM2 proto-oncogene ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chrNW_004955458:15,264,028...15,287,290
Ensembl chrNW_004955458:15,263,739...15,286,808 		JBrowse link
G Por P450 (cytochrome) oxidoreductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chrNW_004955456:14,698,589...14,748,520
Ensembl chrNW_004955456:14,698,589...14,748,520 		JBrowse link
G Ptma prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chrNW_004955453:4,036,503...4,037,788 JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102021956 alpha-2-macroglobulin ISO RGD PMID:19240864 RGD:7411612 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529 		JBrowse link
G Renbp renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chrNW_004955580:610,112...615,019
Ensembl chrNW_004955580:609,964...615,027 		JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:10717410 RGD:8547889 NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142 		JBrowse link
negative regulation of GTP cyclohydrolase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gchfr GTP cyclohydrolase I feedback regulator ISO RGD PMID:8702680 RGD:728623 NCBI chrNW_004955416:7,617,333...7,620,455
Ensembl chrNW_004955416:7,617,333...7,620,455 		JBrowse link
negative regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:15870074 RGD:2325307 NCBI chrNW_004955402:9,091,927...9,099,803
Ensembl chrNW_004955402:9,091,725...9,099,803 		JBrowse link
G Arrb1 arrestin beta 1 ISO RGD PMID:1517224 RGD:631708 NCBI chrNW_004955414:16,478,843...16,568,050
Ensembl chrNW_004955414:16,478,843...16,562,135 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:1517224 RGD:631708 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chrNW_004955478:7,448,584...7,531,860
Ensembl chrNW_004955478:7,478,492...7,531,188 		JBrowse link
G Ptprn2 protein tyrosine phosphatase receptor type N2 ISO RGD PMID:16413169 RGD:1625628 NCBI chrNW_004955579:366,441...862,837
Ensembl chrNW_004955579:364,748...833,729 		JBrowse link
G Rgn regucalcin ISO RGD PMID:11510494 RGD:9590205 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
G Tsc1 TSC complex subunit 1 ISO RGD PMID:15611338 RGD:1601406 NCBI chrNW_004955513:2,197,037...2,244,992
Ensembl chrNW_004955513:2,197,037...2,244,992 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chrNW_004955452:11,142,282...11,150,798
Ensembl chrNW_004955452:11,140,373...11,154,261 		JBrowse link
negative regulation of hexokinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gckr glucokinase regulator ISO RGD PMID:14627435 RGD:1598592 NCBI chrNW_004955469:9,461,541...9,485,034
Ensembl chrNW_004955469:9,461,848...9,484,707 		JBrowse link
negative regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkcz protein kinase C zeta ISO inhibition of acid sphingomyelinase translocation to cell surface and activation RGD PMID:17346242 RGD:1642658 NCBI chrNW_004955486:8,947,579...9,021,702
Ensembl chrNW_004955486:8,947,579...9,021,702 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chrNW_004955422:2,064,010...2,081,681
Ensembl chrNW_004955422:2,061,851...2,082,514 		JBrowse link
negative regulation of kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csk C-terminal Src kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chrNW_004955450:3,127,561...3,144,550
Ensembl chrNW_004955450:3,127,561...3,144,550 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 ISO RGD PMID:19762078 RGD:150429972 NCBI chrNW_004955462:13,578,638...13,644,834
Ensembl chrNW_004955462:13,584,724...13,642,968 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase associated protein 1 ISO RGD PMID:9366267 RGD:5134981 NCBI chrNW_004955506:5,951,210...5,987,658
Ensembl chrNW_004955506:5,951,210...5,987,658 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO due to an autoinhibitory domain RGD PMID:15081430 RGD:2298791 NCBI chrNW_004955454:6,228,492...6,358,690
Ensembl chrNW_004955454:6,228,492...6,358,637 		JBrowse link
negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin ISO RGD PMID:2280766 RGD:9590217 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
negative regulation of lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 ISO RGD PMID:10419291 RGD:1626385 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298 		JBrowse link
G Por P450 (cytochrome) oxidoreductase ISO phospholipase D RGD PMID:18801337 RGD:4889814 NCBI chrNW_004955456:14,698,589...14,748,520
Ensembl chrNW_004955456:14,698,589...14,748,520 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chrNW_004955414:19,146,304...19,163,923
Ensembl chrNW_004955414:19,145,432...19,163,923 		JBrowse link
G Ptpn5 protein tyrosine phosphatase non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chrNW_004955414:33,381,783...33,436,974
Ensembl chrNW_004955414:33,377,322...33,437,118 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chrNW_004955442:15,178,356...15,216,978
Ensembl chrNW_004955442:15,178,487...15,216,362 		JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mprip myosin phosphatase Rho interacting protein ISO RGD PMID:17661354 RGD:9685557 NCBI chrNW_004955577:705,435...838,948
Ensembl chrNW_004955577:705,435...838,948 		JBrowse link
negative regulation of NAD(P)H oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 ISO RGD PMID:19752235 RGD:8549634 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
negative regulation of nitric-oxide synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 ISO RGD PMID:16537391 RGD:1582129 NCBI chrNW_004955466:2,549,557...2,577,060
Ensembl chrNW_004955466:2,549,557...2,577,060 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:18561998 RGD:2316219 NCBI chrNW_004955411:15,052,151...15,077,320
Ensembl chrNW_004955411:15,052,163...15,077,320 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO RGD PMID:18561998 RGD:2316219 NCBI chrNW_004955452:3,763,742...3,795,069
Ensembl chrNW_004955452:3,763,742...3,795,069 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:18005341 RGD:10045554 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137 		JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpin1 lipin 1 ISO RGD PMID:21715287 RGD:38599010 NCBI chrNW_004955487:6,139,188...6,207,316
Ensembl chrNW_004955487:6,138,926...6,210,012 		JBrowse link
negative regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO RGD PMID:2969352 RGD:7421659 NCBI chrNW_004955512:5,686,508...5,703,645 JBrowse link
negative regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snap91 synaptosome associated protein 91 ISO RGD PMID:11779129 RGD:70605 NCBI chrNW_004955411:11,175,587...11,301,145
Ensembl chrNW_004955411:11,175,525...11,300,950 		JBrowse link
negative regulation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snap91 synaptosome associated protein 91 ISO RGD PMID:9188501 RGD:13506241 NCBI chrNW_004955411:11,175,587...11,301,145
Ensembl chrNW_004955411:11,175,525...11,300,950 		JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppia peptidylprolyl isomerase A ISO RGD PMID:19832699 RGD:7247324 NCBI chrNW_004955456:7,381,923...7,383,203 JBrowse link
G Ppp1r9b protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10585469 PMID:12016225 RGD:625568 RGD:9999389 NCBI chrNW_004955451:11,516,548...11,530,263
Ensembl chrNW_004955451:11,516,548...11,530,830 		JBrowse link
G Rgn regucalcin ISO RGD PMID:10922512 RGD:9590172 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505 		JBrowse link
G Daxx death domain associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chrNW_004955437:1,869,692...1,874,041
Ensembl chrNW_004955437:1,869,572...1,873,050 		JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:12688394 RGD:1581394 NCBI chrNW_004955408:28,003,229...28,006,595
Ensembl chrNW_004955408:28,003,229...28,006,595 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:12688394 RGD:1581394 NCBI chrNW_004955514:5,450,495...5,452,282 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO RGD PMID:21668448 RGD:10401931 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428 		JBrowse link
G Il6 interleukin 6 ISO Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Ilk integrin linked kinase ISO GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chrNW_004955414:22,316,243...22,322,979
Ensembl chrNW_004955414:22,316,047...22,322,979 		JBrowse link
G Pcp4 Purkinje cell protein 4 ISO RGD PMID:10751438 RGD:1579763 NCBI chrNW_004955407:39,853,029...39,908,151
Ensembl chrNW_004955407:39,853,034...39,908,151 		JBrowse link
G Rgn regucalcin ISO RGD PMID:11455566 RGD:9590207 NCBI chrNW_004955516:958,416...978,829
Ensembl chrNW_004955516:955,680...978,910 		JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chrNW_004955532:2,059,038...2,079,120
Ensembl chrNW_004955532:2,059,038...2,079,957 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC102021597 alpha-1-antiproteinase S-like ISO RGD PMID:19240864 RGD:7411612 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G Spink1 serine peptidase inhibitor Kazal type 1 ISO RGD PMID:12771515 RGD:724699 NCBI chrNW_004955415:6,328,672...6,378,611
Ensembl chrNW_004955415:6,371,059...6,378,529 		JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:16556873 RGD:1580657 NCBI chrNW_004955429:14,814,690...14,936,869
Ensembl chrNW_004955429:14,873,908...14,937,387 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12267
    biological regulation 8804
      regulation of molecular function 300
        regulation of catalytic activity 182
          negative regulation of catalytic activity 70
            negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity 0
            negative regulation of cyclase activity + 7
            negative regulation of helicase activity + 0
            negative regulation of hydrolase activity + 37
            negative regulation of ligase activity + 1
            negative regulation of lyase activity + 7
            negative regulation of oxidoreductase activity + 5
            negative regulation of prostaglandin-E synthase activity 0
            negative regulation of transferase activity + 23
paths to the root