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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of catalytic activity
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Accession:GO:0043086 term browser browse the term
Definition:Any process that stops or reduces the activity of an enzyme.
Synonyms:exact_synonym: down regulation of enzyme activity;   downregulation of enzyme activity;   negative regulation of enzyme activity
 narrow_synonym: down regulation of metalloenzyme activity;   downregulation of metalloenzyme activity;   inhibition of enzyme activity;   inhibition of metalloenzyme activity;   negative regulation of metalloenzyme activity
 alt_id: GO:0048553


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negative regulation of catalytic activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAST calpastatin ISO RGD PMID:17429681 RGD:1626249 NCBI chr 5:91,972,572...92,084,657
Ensembl chr 5:97,527,071...97,636,650 		JBrowse link
G HNRNPR heterogeneous nuclear ribonucleoprotein R ISO arylalkylamine N-acetyltransferase activity RGD PMID:15798208 RGD:9854643 NCBI chr 1:22,501,816...22,536,050
Ensembl chr 1:23,491,310...23,521,977 		JBrowse link
G RENBP renin binding protein ISO RGD PMID:11726282 RGD:5132613 NCBI chr  X:143,490,103...143,499,487
Ensembl chr  X:153,376,847...153,386,214 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP5 A-kinase anchoring protein 5 ISO RGD PMID:20410303 RGD:7242424 NCBI chr14:45,045,476...45,050,946
Ensembl chr14:63,302,200...63,303,483 		JBrowse link
G AKAP6 A-kinase anchoring protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chr14:12,978,221...13,602,732
Ensembl chr14:31,395,026...31,792,166 		JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chr 7:83,942,590...84,108,648
Ensembl chr 7:97,540,356...97,705,608 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chr 6:29,405,026...29,437,108
Ensembl chr 6:30,065,119...30,095,304 		JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chr20:58,581,228...58,586,585
Ensembl chr20:59,901,327...59,909,901 		JBrowse link
G NPR3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chr 5:77,542,200...77,621,983
Ensembl chr 5:82,926,409...83,004,964 		JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chr 7:17,949,254...17,998,737
Ensembl chr 7:17,278,637...17,326,171 		JBrowse link
negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO RGD PMID:12810716 RGD:632260 NCBI chr11:62,841,377...62,849,664
Ensembl chr11:66,152,670...66,160,898 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:22975349 RGD:8554232 NCBI chr 1:206,915,541...206,976,656 JBrowse link
G RGN regucalcin ISO RGD PMID:1656206 RGD:9590243 NCBI chr  X:39,513,135...39,530,188
Ensembl chr  X:47,371,226...47,388,881 		JBrowse link
negative regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 ISO RGD PMID:10721722 RGD:632478 NCBI chr 9:91,519,179...91,707,469
Ensembl chr 9:119,868,015...120,055,608 		JBrowse link
G CDK5RAP3 CDK5 regulatory subunit associated protein 3 ISO RGD PMID:10721722 RGD:632478 NCBI chr17:9,556,313...9,567,099
Ensembl chr17:9,738,141...9,749,302 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO RGD PMID:22584582 RGD:10045364 NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G HTT huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chr 4:3,215,081...3,388,587
Ensembl chr 4:3,128,718...3,283,730 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr19:37,275,799...37,331,971
Ensembl chr19:45,791,800...45,840,271 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G EP300 E1A binding protein p300 ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr22:21,986,467...22,076,921
Ensembl chr22:40,079,503...40,168,604 		JBrowse link
G GPI glucose-6-phosphate isomerase ISO RGD PMID:12615053 RGD:1600634 NCBI chr19:31,301,469...31,355,362
Ensembl chr19:40,024,584...40,080,598 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chr16:37,210,170...37,221,961
Ensembl chr16:56,343,025...56,355,164 		JBrowse link
G HNF1A HNF1 homeobox A ISO RGD PMID:21874357 RGD:150540304 NCBI chr12:118,562,308...118,584,596
Ensembl chr12:121,932,671...121,955,911 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B ISO reduced cleavage of Casp8 and Casp9 in brain following hypoxic/ischemic injury RGD PMID:16397188 RGD:1626654 NCBI chr 6:31,488,882...31,491,412 JBrowse link
G IL6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G LOC100990437 NADPH--cytochrome P450 reductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr 7:68,035,021...68,105,934
Ensembl chr 7:82,364,418...82,437,530 		JBrowse link
G MDM2 MDM2 proto-oncogene ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr12:66,322,340...66,357,010
Ensembl chr12:69,102,084...69,133,278 		JBrowse link
G PTMA prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chr2B:118,959,382...118,964,364 JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:19240864 RGD:7411612 NCBI chr12:9,154,457...9,202,833
Ensembl chr12:9,385,359...9,433,979 		JBrowse link
G RENBP renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chr  X:143,490,103...143,499,487
Ensembl chr  X:153,376,847...153,386,214 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:10717410 RGD:8547889 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
negative regulation of GTP cyclohydrolase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCHFR GTP cyclohydrolase I feedback regulator ISO RGD PMID:8702680 RGD:728623 NCBI chr15:19,704,891...19,708,686
Ensembl chr15:37,957,109...37,960,973 		JBrowse link
negative regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:15870074 RGD:2325307 NCBI chr18:13,414,618...13,421,668
Ensembl chr18:15,713,479...15,717,749 		JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:1517224 RGD:631708 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:1517224 RGD:631708 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chr17:58,417,134...58,526,409
Ensembl chr17:63,511,784...63,579,067 		JBrowse link
G PTPRN2 protein tyrosine phosphatase receptor type N2 ISO RGD PMID:16413169 RGD:1625628 NCBI chr 7:149,158,513...150,390,077
Ensembl chr 7:160,851,703...161,756,325 		JBrowse link
G RGN regucalcin ISO RGD PMID:11510494 RGD:9590205 NCBI chr  X:39,513,135...39,530,188
Ensembl chr  X:47,371,226...47,388,881 		JBrowse link
G TSC1 TSC complex subunit 1 ISO RGD PMID:15611338 RGD:1601406 NCBI chr 9:104,007,708...104,060,938
Ensembl chr 9:132,638,003...132,675,759 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 1:32,176,465...32,185,133
Ensembl chr 1:33,363,673...33,371,524 		JBrowse link
negative regulation of hexokinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCKR glucokinase regulator ISO RGD PMID:14627435 RGD:1598592 NCBI chr2A:27,497,938...27,530,650
Ensembl chr2A:27,587,077...27,613,927 		JBrowse link
negative regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCZ protein kinase C zeta ISO inhibition of acid sphingomyelinase translocation to cell surface and activation RGD PMID:17346242 RGD:1642658 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 ISO RGD PMID:12064607 RGD:1299562 NCBI chr11:45,839,754...45,860,615
Ensembl chr11:46,332,159...46,352,010 		JBrowse link
negative regulation of kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSK C-terminal Src kinase ISO RGD PMID:10411542 RGD:5134371 NCBI chr15:53,724,814...53,745,710
Ensembl chr15:73,342,703...73,363,476 		JBrowse link
G DDR2 discoidin domain receptor tyrosine kinase 2 ISO RGD PMID:19762078 RGD:150429972 NCBI chr 1:138,048,730...138,200,426
Ensembl chr 1:141,932,158...141,990,766 		JBrowse link
G PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 ISO RGD PMID:9366267 RGD:5134981 NCBI chr17:70,258,663...70,302,287
Ensembl chr17:75,810,423...75,853,442 		JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 ISO due to an autoinhibitory domain RGD PMID:15081430 RGD:2298791 NCBI chr12:825,659...985,016
Ensembl chr12:791,153...944,602 		JBrowse link
negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:2280766 RGD:9590217 NCBI chr  X:39,513,135...39,530,188
Ensembl chr  X:47,371,226...47,388,881 		JBrowse link
negative regulation of lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 ISO RGD PMID:10419291 RGD:1626385 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122 		JBrowse link
G LOC100990437 NADPH--cytochrome P450 reductase ISO phospholipase D RGD PMID:18801337 RGD:4889814 NCBI chr 7:68,035,021...68,105,934
Ensembl chr 7:82,364,418...82,437,530 		JBrowse link
negative regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:17182785 RGD:2301767 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G INPPL1 inositol polyphosphate phosphatase like 1 ISO RGD PMID:12933696 RGD:1626126 NCBI chr11:67,302,066...67,317,785
Ensembl chr11:70,527,017...70,540,846 		JBrowse link
G PTPN5 protein tyrosine phosphatase non-receptor type 5 ISO RGD PMID:9857190 RGD:10044039 NCBI chr11:18,758,285...18,822,845
Ensembl chr11:18,673,366...18,711,885 		JBrowse link
G TSC2 TSC complex subunit 2 ISO RGD PMID:14612383 RGD:1580517 NCBI chr16:615,776...655,411
Ensembl chr16:2,135,696...2,175,569 		JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPRIP myosin phosphatase Rho interacting protein ISO RGD PMID:17661354 RGD:9685557 NCBI chr17:34,101,451...34,251,475
Ensembl chr17:39,040,719...39,182,578 		JBrowse link
negative regulation of NAD(P)H oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL13 interleukin 13 ISO RGD PMID:19752235 RGD:8549634 NCBI chr 5:128,073,863...128,078,453
Ensembl chr 5:134,235,788...134,240,548 		JBrowse link
negative regulation of nitric-oxide synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG2 arginase 2 ISO RGD PMID:16537391 RGD:1582129 NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:18561998 RGD:2316219 NCBI chr 6:86,017,141...86,044,889 JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:18561998 RGD:2316219 NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO RGD PMID:18005341 RGD:10045554 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LPIN1 lipin 1 ISO RGD PMID:21715287 RGD:38599010 NCBI chr2A:11,664,727...11,815,497
Ensembl chr2A:11,857,961...11,961,551 		JBrowse link
negative regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:2969352 RGD:7421659 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
negative regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:11779129 RGD:70605 NCBI chr 6:81,441,792...81,600,505
Ensembl chr 6:84,720,850...84,874,407 		JBrowse link
negative regulation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:9188501 RGD:13506241 NCBI chr 6:81,441,792...81,600,505
Ensembl chr 6:84,720,850...84,874,407 		JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPIA peptidylprolyl isomerase A ISO RGD PMID:19832699 RGD:7247324 NCBI chr 7:45,510,450...45,515,448
Ensembl chr 7:45,578,765...45,605,545 		JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10585469 PMID:12016225 RGD:625568 RGD:9999389 NCBI chr17:44,224,007...44,240,906
Ensembl chr17:49,098,089...49,126,932 		JBrowse link
G RGN regucalcin ISO RGD PMID:10922512 RGD:9590172 NCBI chr  X:39,513,135...39,530,188
Ensembl chr  X:47,371,226...47,388,881 		JBrowse link
negative regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO in PC12 cells, PKCzeta deactivated after long-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189 		JBrowse link
G DAXX death domain associated protein ISO RGD PMID:17289031 RGD:9587773 NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717 		JBrowse link
G DRD1 dopamine receptor D1 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 5:170,787,115...170,792,383
Ensembl chr 5:177,688,917...177,690,257 		JBrowse link
G DRD5 dopamine receptor D5 ISO RGD PMID:12688394 RGD:1581394 NCBI chr 4:4,189,536...4,193,144
Ensembl chr 4:9,509,094...9,510,527 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO RGD PMID:21668448 RGD:10401931 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G IL6 interleukin 6 ISO Phospholamban phosphorylation RGD PMID:15845578 RGD:2306941 NCBI chr 7:23,415,922...23,420,767 JBrowse link
G ILK integrin linked kinase ISO GSK-3 activity as a Tau protein kinase RGD PMID:12629168 RGD:2302091 NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788 		JBrowse link
G PCP4 Purkinje cell protein 4 ISO RGD PMID:10751438 RGD:1579763 NCBI chr21:26,069,039...26,284,247
Ensembl chr21:39,587,400...39,618,734 		JBrowse link
G RGN regucalcin ISO RGD PMID:11455566 RGD:9590207 NCBI chr  X:39,513,135...39,530,188
Ensembl chr  X:47,371,226...47,388,881 		JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chr 3:50,154,731...50,187,948
Ensembl chr 3:51,398,981...51,421,988 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINA1 serpin family A member 1 ISO RGD PMID:19240864 RGD:7411612 NCBI chr14:75,001,714...75,014,214
Ensembl chr14:94,334,258...94,345,419 		JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 ISO RGD PMID:12771515 RGD:724699 NCBI chr 5:143,273,137...143,287,745 JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma ISO RGD PMID:16556873 RGD:1580657 NCBI chr 3:12,215,322...12,361,669
Ensembl chr 3:12,622,397...12,705,060 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15680
    biological regulation 10752
      regulation of molecular function 305
        regulation of catalytic activity 187
          negative regulation of catalytic activity 71
            negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity 0
            negative regulation of cyclase activity + 7
            negative regulation of helicase activity + 0
            negative regulation of hydrolase activity + 38
            negative regulation of ligase activity + 1
            negative regulation of lyase activity + 7
            negative regulation of oxidoreductase activity + 5
            negative regulation of prostaglandin-E synthase activity 0
            negative regulation of transferase activity + 23
paths to the root