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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of catalytic activity
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Accession:GO:0043085 term browser browse the term
Definition:Any process that activates or increases the activity of an enzyme.
Synonyms:exact_synonym: positive regulation of enzyme activity;   up regulation of enzyme activity;   upregulation of enzyme activity
 narrow_synonym: activation of enzyme activity;   activation of metalloenzyme activity;   positive regulation of metalloenzyme activity;   stimulation of enzyme activity;   stimulation of metalloenzyme activity;   up regulation of metalloenzyme activity;   upregulation of metalloenzyme activity
 alt_id: GO:0048554


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positive regulation of catalytic activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen ISO RGD PMID:11100981 RGD:1582152 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G CDC42 cell division cycle 42 ISO RGD PMID:18562481 RGD:5688290 NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233 		JBrowse link
G CLPS colipase ISO RGD PMID:8656075 RGD:2303166 NCBI chr 7:31,618,920...31,621,132
Ensembl chr 7:31,618,920...31,621,132 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 ISO Eno1 RGD PMID:21958194 RGD:10059326 NCBI chr 9:49,982,278...49,986,760
Ensembl chr 9:49,982,284...49,990,508 		JBrowse link
G NGB neuroglobin ISO RGD PMID:23036890 RGD:9743969 NCBI chr 7:100,341,974...100,346,263
Ensembl chr 7:100,340,940...100,346,438 		JBrowse link
G NPM1 nucleophosmin 1 ISO DNA polymerase alpha RGD PMID:11481036 RGD:1600909 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,298...52,781,771 		JBrowse link
G NPM2 nucleophosmin/nucleoplasmin 2 ISO DNA polymerase alpha, lesser effect than Npm1 RGD PMID:11481036 RGD:1600909 NCBI chr14:6,288,422...6,303,750
Ensembl chr14:6,289,337...6,303,748 		JBrowse link
activation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRHR growth hormone releasing hormone receptor ISO RGD PMID:9845677 RGD:1601338 NCBI chr18:42,030,505...42,046,178
Ensembl chr18:42,030,510...42,046,184 		JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor ISO RGD PMID:8440169 RGD:2292602 NCBI chr 3:91,964,415...92,023,821
Ensembl chr 3:91,964,415...92,021,398 		JBrowse link
G VIPR2 vasoactive intestinal peptide receptor 2 ISO RGD PMID:8224221 RGD:70054 NCBI chr18:396,379...466,408
Ensembl chr18:396,263...518,102 		JBrowse link
activation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAWR pro-apoptotic WT1 regulator ISO RGD PMID:10349840 RGD:9835366 NCBI chr 5:101,693,145...101,797,842
Ensembl chr 5:101,693,246...101,797,838 		JBrowse link
activation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCK cholecystokinin ISO RGD PMID:11964411 RGD:625521 NCBI chr13:25,940,674...25,945,879
Ensembl chr13:25,937,645...25,945,793 		JBrowse link
G TNFSF15 TNF superfamily member 15 ISO RGD PMID:11911831 RGD:634236 NCBI chr 1:255,328,731...255,349,508
Ensembl chr 1:255,328,719...255,349,539 		JBrowse link
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMAD3 SMAD family member 3 ISO TGF-beta1-induced cleavage of BAD to its more active 15 kD form RGD PMID:11839804 RGD:2301029 NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449 		JBrowse link
activation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF5 eukaryotic translation initiation factor 5 ISO RGD PMID:10805737 RGD:10755758
G PTK2B protein tyrosine kinase 2 beta ISO RGD PMID:15158121 RGD:1642626 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
G RASA1 RAS p21 protein activator 1 ISO RGD PMID:8226805 RGD:9999452 NCBI chr 2:94,879,615...94,992,725
Ensembl chr 2:94,878,911...94,993,450 		JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 ISO RGD PMID:1379346 RGD:10003125 NCBI chr 7:48,121,415...48,246,749
Ensembl chr 7:48,121,419...48,246,749 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 ISO RGD PMID:18930714 RGD:10043296 NCBI chr13:194,774,495...195,235,750
Ensembl chr13:194,774,497...195,005,089 		JBrowse link
activation of Janus kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:9314843 RGD:6478796 NCBI chr13:88,934,873...88,980,317
Ensembl chr13:88,934,868...88,983,105 		JBrowse link
G GHR growth hormone receptor ISO RGD PMID:11244571 RGD:1624962 NCBI chr16:27,126,300...27,422,618
Ensembl chr16:27,126,734...27,421,449 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO RGD PMID:11818507 RGD:633057 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
activation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1R1 ADCYAP receptor type I ISO RGD PMID:8396727 RGD:631732 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301 		JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO RGD PMID:7935320 RGD:69745 NCBI chr14:10,623,391...10,733,378
Ensembl chr14:10,626,293...10,733,068 		JBrowse link
G AGT angiotensinogen ISO RGD PMID:11100981 RGD:1582152 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G DLC1 DLC1 Rho GTPase activating protein ISO RGD PMID:7835339 RGD:68218 NCBI chr17:1,169,709...1,637,171
Ensembl chr17:1,170,208...1,637,114 		JBrowse link
G GNAQ G protein subunit alpha q ISO RGD PMID:14981460 RGD:1598489 NCBI chr 1:230,607,469...230,906,988
Ensembl chr 1:230,605,265...230,907,674 		JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO RGD PMID:11388899 RGD:1599963 NCBI chr 2:11,400,415...11,420,314
Ensembl chr 2:11,400,420...11,420,298 		JBrowse link
activation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNA13 G protein subunit alpha 13 ISO RGD PMID:12435801 RGD:1598460 NCBI chr12:11,922,630...11,966,913
Ensembl chr12:11,922,632...11,966,610 		JBrowse link
G HPCA hippocalcin ISO RGD PMID:11211872 RGD:9686445 NCBI chr 6:89,187,544...89,197,049
Ensembl chr 6:89,188,133...89,197,045 		JBrowse link
G MARCKS myristoylated alanine rich protein kinase C substrate ISO RGD PMID:16341931 RGD:9685306 NCBI chr 1:79,789,796...79,795,895
Ensembl chr 1:79,789,815...79,795,760 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:16113073 RGD:1642674 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472 		JBrowse link
activation of protein kinase A activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UCN urocortin ISO RGD PMID:19460778 RGD:5508168 NCBI chr 3:111,834,082...111,835,932
Ensembl chr 3:111,835,125...111,835,508 		JBrowse link
activation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADNP activity dependent neuroprotector homeobox ISO Fyn kinase RGD PMID:19047645 RGD:2312772 NCBI chr17:52,316,388...52,350,732
Ensembl chr17:52,317,913...52,332,079 		JBrowse link
G CAMKK1 calcium/calmodulin dependent protein kinase kinase 1 ISO RGD PMID:16054095 RGD:2311420 NCBI chr12:49,922,837...49,950,668
Ensembl chr12:49,922,855...49,950,605 		JBrowse link
G CAMKK2 calcium/calmodulin dependent protein kinase kinase 2 ISO RGD PMID:16054095 RGD:2311420 NCBI chr14:31,307,418...31,366,504
Ensembl chr14:31,312,049...31,366,499 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:12086672 RGD:1580677 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599 		JBrowse link
G HNF1A HNF1 homeobox A ISO RGD PMID:20841353 RGD:150540305 NCBI chr14:40,868,819...40,888,322
Ensembl chr14:40,868,676...40,888,328 		JBrowse link
activation of protein kinase B activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCZ protein kinase C zeta ISO in hepatocytes RGD PMID:15007074 RGD:1642700 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472 		JBrowse link
negative regulation of activation of Janus kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF4A hepatocyte nuclear factor 4 alpha ISO RGD PMID:16584384 RGD:1625011 NCBI chr17:46,783,772...46,847,505
Ensembl chr17:46,783,777...46,847,500 		JBrowse link
positive regulation of adenylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:21143600 RGD:8693686 NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,330...124,401,739 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 ISO RGD PMID:20410303 RGD:7242424 NCBI chr 7:88,538,938...88,544,330
Ensembl chr 7:88,538,984...88,547,392 		JBrowse link
G GCG glucagon ISO RGD PMID:2235678 RGD:11556254 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,560...68,810,242 		JBrowse link
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 6:89,187,544...89,197,049
Ensembl chr 6:89,188,133...89,197,045 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:15901773 RGD:1598578 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,834 		JBrowse link
positive regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGA2 integrin subunit alpha 2 ISO RGD PMID:10867645 RGD:2307406 NCBI chr16:32,336,240...32,440,311
Ensembl chr16:32,336,292...32,437,103 		JBrowse link
G SMAD3 SMAD family member 3 ISO rat gene expressed in mouse osteoblastic cell line MC3T3-E1; TGF-beta down-regulates this activity RGD PMID:12096832 RGD:727387 NCBI chr 1:164,998,457...165,124,455
Ensembl chr 1:164,998,103...165,124,449 		JBrowse link
positive regulation of cAMP-dependent protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454 		JBrowse link
positive regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAT1 G protein subunit alpha transducin 1 ISO RGD PMID:7878085 RGD:1599022 NCBI chr13:32,671,377...32,678,394
Ensembl chr13:32,671,432...32,678,391 		JBrowse link
positive regulation of cyclin-dependent protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC6 cell division cycle 6 ISO RGD PMID:22223646 RGD:10045360 NCBI chr12:22,101,281...22,118,441
Ensembl chr12:22,101,282...22,118,593 		JBrowse link
G CDK5RAP1 CDK5 regulatory subunit associated protein 1 ISO RGD PMID:10721722 RGD:632478 NCBI chr17:36,877,570...36,911,344
Ensembl chr17:36,877,650...36,908,019 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO RGD PMID:22223646 RGD:10045360 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15105833 RGD:2313858 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:19171933 RGD:5510006 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,516,947...9,597,976 		JBrowse link
G CCN2 cellular communication network factor 2 ISO caspase 3/7 RGD PMID:19625611 RGD:2314487 NCBI chr 1:31,674,398...31,677,697
Ensembl chr 1:31,674,394...31,677,691 		JBrowse link
G FAS Fas cell surface death receptor ISO RGD PMID:15519734 RGD:8662904 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G HSF1 heat shock transcription factor 1 ISO RGD PMID:21192280 RGD:10403035 NCBI chr 4:463,531...486,483
Ensembl chr 4:463,393...486,473 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO RGD PMID:14522843 RGD:2304239 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:18322138 RGD:8693423 NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646 		JBrowse link
G PYCARD PYD and CARD domain containing ISO RGD PMID:19401709 RGD:5491174 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786 		JBrowse link
G RHOA ras homolog family member A ISO RGD PMID:17425560 RGD:1642961 NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607 		JBrowse link
G WDR35 WD repeat domain 35 ISO RGD PMID:20193664 RGD:11553917 NCBI chr 3:118,209,112...118,279,050
Ensembl chr 3:118,209,139...118,269,452 		JBrowse link
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor ISO RGD PMID:12131680 RGD:14995454 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
positive regulation of cytochrome-c oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO RGD PMID:15107407 RGD:1578311 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094 		JBrowse link
G MYO5A myosin VA ISO RGD PMID:29217155 RGD:42721980 NCBI chr 1:119,165,751...119,398,591
Ensembl chr 1:119,165,942...119,394,725 		JBrowse link
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNRNPU heterogeneous nuclear ribonucleoprotein U ISO RGD PMID:20554522 RGD:10058983 NCBI chr10:17,475,266...17,497,060
Ensembl chr10:17,477,902...17,497,030 		JBrowse link
positive regulation of DNA-directed DNA polymerase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPM1 nucleophosmin 1 ISO RGD PMID:8123045 RGD:11535022 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,298...52,781,771 		JBrowse link
positive regulation of dUTP diphosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:1315924 RGD:2301218 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
positive regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKIRIN2 akirin 2 ISO MMP-9 RGD PMID:18460465 RGD:2306009 NCBI chr 1:56,047,188...56,075,342
Ensembl chr 1:56,046,327...56,070,163 		JBrowse link
positive regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor ISO RGD PMID:19574994 RGD:2317913 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365 		JBrowse link
positive regulation of exoribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TCEA1 transcription elongation factor A1 ISO RGD PMID:16046193 RGD:9693728 NCBI chr 4:77,109,555...77,138,324
Ensembl chr 4:77,109,594...77,138,320 		JBrowse link
positive regulation of glucokinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP12 dual specificity phosphatase 12 ISO increases glucokinase activity by direct dephosphorylation RGD PMID:10913113 RGD:68242 NCBI chr 4:88,811,565...88,818,513
Ensembl chr 4:88,809,565...88,818,411 		JBrowse link
G PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 ISO RGD PMID:15047617 RGD:2302684 NCBI chr  X:47,771,751...47,859,079
Ensembl chr  X:47,765,154...47,859,061 		JBrowse link
G PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 ISO RGD PMID:16980436 RGD:2304071 NCBI chr 9:67,681,786...67,716,921
Ensembl chr 9:67,681,953...67,709,516 		JBrowse link
positive regulation of glutamate-cysteine ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLM glutamate-cysteine ligase modifier subunit ISO RGD PMID:16137247 RGD:1582663 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131 		JBrowse link
positive regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMPH amphiphysin ISO RGD PMID:9348539 RGD:631926 NCBI chr 9:108,800,718...108,971,575
Ensembl chr 9:108,799,793...108,971,660 		JBrowse link
G BIN1 bridging integrator 1 ISO RGD PMID:9348539 RGD:631926 NCBI chr15:25,328,679...25,379,675
Ensembl chr15:25,328,674...25,383,652 		JBrowse link
G GNAO1 G protein subunit alpha o1 ISO RGD PMID:7544301 RGD:2302012 NCBI chr 6:29,416,574...29,592,874
Ensembl chr 6:29,416,708...29,592,516 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO basal and EGF-activated Rac1 RGD PMID:17183546 RGD:2292641 NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226 		JBrowse link
G RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 ISO RGD PMID:18348285 RGD:2314690 NCBI chr 8:121,866,803...122,007,492
Ensembl chr 8:121,866,805...122,082,948 		JBrowse link
G RASA1 RAS p21 protein activator 1 ISO RGD PMID:14707121 RGD:9999423 NCBI chr 2:94,879,615...94,992,725
Ensembl chr 2:94,878,911...94,993,450 		JBrowse link
G RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 ISO RGD PMID:15798216 RGD:10003119 NCBI chr 7:48,121,415...48,246,749
Ensembl chr 7:48,121,419...48,246,749 		JBrowse link
G RGN regucalcin ISO RGD PMID:11693188 RGD:9590216 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:9430692 PMID:20530129 RGD:7207369 RGD:7207375 NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,383,345...87,390,893 		JBrowse link
G S1PR1 sphingosine-1-phosphate receptor 1 ISO RGD PMID:14711826 RGD:1304283 NCBI chr 4:117,064,632...117,069,724
Ensembl chr 4:117,064,755...117,069,650 		JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCA1A guanylate cyclase activator 1A ISO RGD PMID:12545196 RGD:1599357 NCBI chr 7:37,282,630...37,296,713
Ensembl chr 7:37,282,700...37,296,717 		JBrowse link
positive regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP1 fatty acid binding protein 1 ISO peroxisomal medium- and long-chain acyl-CoA thioesterases RGD PMID:16262600 RGD:1626442 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,956 		JBrowse link
G GM2A ganglioside GM2 activator ISO Phospholipase D RGD PMID:9770472 RGD:1598995 NCBI chr16:71,742,090...71,767,872
Ensembl chr16:71,742,090...71,754,884 		JBrowse link
positive regulation of isoleucine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPL5 ribosomal protein L5 ISO RGD PMID:1665486 RGD:11040680 NCBI chr 4:124,359,786...124,367,612
Ensembl chr 4:124,358,594...124,367,645 		JBrowse link
positive regulation of JUN kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1RN interleukin 1 receptor antagonist ISO RGD PMID:12667655 RGD:1626684
G LOC110258578 interleukin-1 beta-like ISO RGD PMID:12667655 RGD:1626684
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9110999 RGD:2293488 NCBI chr16:35,872,301...35,947,097
Ensembl chr16:35,872,131...35,946,987 		JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 ISO RGD PMID:20716917 RGD:10412640 NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,493 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO RGD PMID:15226266 RGD:1642623 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
G ROR2 receptor tyrosine kinase like orphan receptor 2 ISO RGD PMID:25825749 RGD:11537351 NCBI chr14:2,803,840...3,035,384
Ensembl chr14:2,804,061...3,035,296 		JBrowse link
G TIAM1 TIAM Rac1 associated GEF 1 ISO RGD PMID:16203995 RGD:10043312 NCBI chr13:194,774,495...195,235,750
Ensembl chr13:194,774,497...195,005,089 		JBrowse link
positive regulation of MAP kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSK C-terminal Src kinase ISO RGD PMID:10884975 RGD:5134370 NCBI chr 7:58,736,473...58,755,034
Ensembl chr 7:58,736,531...58,755,260 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A ISO RGD PMID:15087293 RGD:1624373 NCBI chr11:20,555,939...20,620,225
Ensembl chr11:20,555,963...20,619,625 		JBrowse link
G ILK integrin linked kinase ISO inhibits Gsk3b which in turn inhibits Erk/Mapk3 activation RGD PMID:17182785 RGD:2301767 NCBI chr 9:3,145,647...3,152,097
Ensembl chr 9:3,145,608...3,159,858 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO RGD PMID:10969813 RGD:1600497 NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 ISO RGD PMID:9110999 RGD:2293488 NCBI chr16:35,872,301...35,947,097
Ensembl chr16:35,872,131...35,946,987 		JBrowse link
G PRKCD protein kinase C delta ISO RGD PMID:16935468 RGD:1642549 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:11941412 RGD:150523765 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO RGD PMID:21607062 RGD:5508182 NCBI chr 5:8,827,363...8,852,814
Ensembl chr 5:8,826,840...8,852,776 		JBrowse link
positive regulation of methionine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPL5 ribosomal protein L5 ISO RGD PMID:1665486 RGD:11040680 NCBI chr 4:124,359,786...124,367,612
Ensembl chr 4:124,358,594...124,367,645 		JBrowse link
positive regulation of NAD(P)H oxidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYBA cytochrome b-245 alpha chain ISO RGD PMID:12631082 RGD:11040676 NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420 		JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:27912212 RGD:13507308 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,794 		JBrowse link
G GNAI3 G protein subunit alpha i3 ISO RGD PMID:27912212 RGD:13507308 NCBI chr 4:110,527,363...110,579,331
Ensembl chr 4:110,525,546...110,579,053 		JBrowse link
positive regulation of nitric-oxide synthase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO RGD PMID:20529840 RGD:7241266 NCBI chr 7:112,160,823...112,171,754
Ensembl chr 7:112,160,806...112,171,744 		JBrowse link
G CALM2 calmodulin 2 ISO RGD PMID:20529840 RGD:7241266 NCBI chr 3:93,371,765...93,386,378
Ensembl chr 3:93,372,045...93,386,218 		JBrowse link
G CALM3 calmodulin 3 ISO RGD PMID:20529840 RGD:7241266 NCBI chr 6:52,506,979...52,516,704
Ensembl chr 6:52,506,674...52,516,703 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO RGD PMID:14576830 RGD:1600488 NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358 		JBrowse link
G NOD1 nucleotide binding oligomerization domain containing 1 ISO RGD PMID:22870324 RGD:9831169 NCBI chr18:42,464,667...42,509,135
Ensembl chr18:42,432,050...42,512,264 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO RGD PMID:21926342 RGD:10041069 NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192 		JBrowse link
G TNF tumor necrosis factor ISO RGD PMID:9537427 RGD:14985259 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
positive regulation of oxidoreductase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FDX1 ferredoxin 1 ISO p-nitrophenol hydroxylase, dimethylnitrosamine demethylase RGD PMID:11325963 RGD:4145669 NCBI chr 9:38,376,147...38,399,026
Ensembl chr 9:38,375,984...38,404,832 		JBrowse link
positive regulation of phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:9671264 RGD:9590174 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
G RPL5 ribosomal protein L5 ISO RGD PMID:7649987 RGD:2316860 NCBI chr 4:124,359,786...124,367,612
Ensembl chr 4:124,358,594...124,367,645 		JBrowse link
positive regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta ISO RGD PMID:15576376 RGD:6482753 NCBI chr18:50,862,225...50,956,263
Ensembl chr18:50,861,466...50,956,225 		JBrowse link
positive regulation of phospholipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPCA hippocalcin ISO RGD PMID:11211872 RGD:9686445 NCBI chr 6:89,187,544...89,197,049
Ensembl chr 6:89,188,133...89,197,045 		JBrowse link
positive regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTAFR platelet activating factor receptor ISO RGD PMID:8798508 RGD:9999203 NCBI chr 6:85,235,390...85,272,360
Ensembl chr 6:85,235,394...85,261,760 		JBrowse link
positive regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G JAK2 Janus kinase 2 ISO Ptpn11 activity RGD PMID:17021051 RGD:1641809 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G PAWR pro-apoptotic WT1 regulator ISO RGD PMID:23219599 RGD:9835413 NCBI chr 5:101,693,145...101,797,842
Ensembl chr 5:101,693,246...101,797,838 		JBrowse link
G PPP2CA protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:24265448 RGD:8693600 NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646 		JBrowse link
positive regulation of protein kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AXIN1 axin 1 ISO RGD PMID:15228590 RGD:1304344 NCBI chr 3:41,344,908...41,393,999
Ensembl chr 3:41,337,071...41,393,997 		JBrowse link
G AXIN2 axin 2 ISO RGD PMID:9566905 RGD:68736 NCBI chr12:12,311,293...12,343,207
Ensembl chr12:12,311,298...12,343,200 		JBrowse link
G CAMKK1 calcium/calmodulin dependent protein kinase kinase 1 ISO RGD PMID:7642608 RGD:632489 NCBI chr12:49,922,837...49,950,668
Ensembl chr12:49,922,855...49,950,605 		JBrowse link
G CCNB1 cyclin B1 ISO histone H1 RGD PMID:15291744 RGD:1578405 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377 		JBrowse link
G DAG1 dystroglycan 1 ISO RGD PMID:18556591 RGD:11541067 NCBI chr13:32,028,019...32,092,450
Ensembl chr13:32,029,522...32,092,450 		JBrowse link
G DAXX death domain associated protein ISO RGD PMID:21572393 RGD:9587767 NCBI chr 7:29,676,854...29,681,145
Ensembl chr 7:29,676,856...29,681,110 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:9653190 RGD:8554053 NCBI chr 9:74,635,285...74,944,050
Ensembl chr 9:74,635,403...74,940,362 		JBrowse link
G SDC4 syndecan 4 ISO RGD PMID:12571249 RGD:1580031 NCBI chr17:47,650,387...47,670,499 JBrowse link
positive regulation of protein kinase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MARCKS myristoylated alanine rich protein kinase C substrate ISO RGD PMID:16341931 RGD:9685306 NCBI chr 1:79,789,796...79,795,895
Ensembl chr 1:79,789,815...79,795,760 		JBrowse link
G ROR2 receptor tyrosine kinase like orphan receptor 2 ISO RGD PMID:25825749 RGD:11537351 NCBI chr14:2,803,840...3,035,384
Ensembl chr14:2,804,061...3,035,296 		JBrowse link
positive regulation of protein serine/threonine kinase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90AB1 heat shock protein 90 alpha family class B member 1 ISO Akt1 RGD PMID:18443201 RGD:4108490 NCBI chr 7:39,237,299...39,250,479
Ensembl chr 7:39,244,458...39,250,481 		JBrowse link
positive regulation of superoxide dismutase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGN regucalcin ISO RGD PMID:15375603 RGD:9590277 NCBI chr  X:41,725,660...41,749,736
Ensembl chr  X:41,726,526...41,749,381 		JBrowse link
positive regulation of threonine-tRNA ligase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPL5 ribosomal protein L5 ISO RGD PMID:8049265 RGD:1556518 NCBI chr 4:124,359,786...124,367,612
Ensembl chr 4:124,358,594...124,367,645 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    biological regulation 12832
      regulation of molecular function 303
        regulation of catalytic activity 186
          positive regulation of catalytic activity 112
            positive regulation of cyclase activity + 9
            positive regulation of helicase activity + 0
            positive regulation of hydrolase activity + 49
            positive regulation of isomerase activity + 1
            positive regulation of ligase activity + 2
            positive regulation of lyase activity + 9
            positive regulation of oxidoreductase activity + 14
            positive regulation of transferase activity + 42
paths to the root