ONTOLOGY REPORT - ANNOTATIONS
Term: tRNA aminoacylation
Accession: GO:0043039
browse the term
Definition: The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.
Synonyms: exact_synonym: aminoacyl-tRNA biosynthesis; aminoacyl-tRNA biosynthetic process; tRNA charging
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Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
involved_in
ISO
(PMID:15779907), (PMID:17384640)
RGD
PMID:15779907 PMID:17384640
NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934
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Fars2
phenylalanyl-tRNA synthetase 2, mitochondrial
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337
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Yars2
tyrosyl-tRNA synthetase 2
involved_in
ISO IBA
(PMID:15779907), (PMID:15840810), (PMID:17997975) PMID:21873635
RGD
PMID:15779907 PMID:15840810 PMID:17997975 PMID:21873635
RGD:13792537
NCBI chr11:84,632,350...84,638,138
Ensembl chr11:84,624,369...84,638,125
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Aars1
alanyl-tRNA synthetase 1
involved_in acts_upstream_of_or_within
IDA ISO IBA
(PMID:27622773), (PMID:28493438), (PMID:33909043) MGI:3618596 (MGI:3640843|PMID:16906134) (MGI:5905209|PMID:27622773) PMID:21873635
RGD
PMID:16906134 PMID:27622773 PMID:28493438 PMID:33909043 PMID:2040280 PMID:21873635 More...
MGI:3640843 MGI:5905209 , RGD:2302982 , RGD:13792537
NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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Aars2
alanyl-tRNA synthetase 2, mitochondrial
involved_in
IBA IEA
PMID:21873635 GO_REF:0000002
InterPro
PMID:21873635
GO_REF:0000002, RGD:13792537
NCBI chr 9:15,484,639...15,496,116
Ensembl chr 9:15,297,531...15,496,090
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Aarsd1
alanyl-tRNA synthetase domain containing 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr10:86,340,625...86,353,732
Ensembl chr10:86,340,626...86,353,729
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Dalrd3
DALR anticodon binding domain containing 3
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 8:109,264,100...109,268,560
Ensembl chr 8:109,265,676...109,268,568
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Rars1
arginyl-tRNA synthetase 1
involved_in
IDA ISO IBA
(MGI:3055639|PMID:12060739) PMID:21873635 (PMID:25288775)
RGD
PMID:12060739 PMID:25288775 PMID:7082655 PMID:21873635
MGI:3055639 , RGD:2303394 , RGD:13792537
NCBI chr10:20,270,744...20,295,192
Ensembl chr10:20,270,483...20,295,196
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Rars2
arginyl-tRNA synthetase 2, mitochondrial
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 5:49,181,517...49,238,664
Ensembl chr 5:49,181,565...49,233,276
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Nars1
asparaginyl-tRNA synthetase 1
involved_in
ISO IBA
(PMID:9421509) PMID:21873635
RGD
PMID:9421509 PMID:21873635
RGD:13792537
NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622
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Nars2
asparaginyl-tRNA synthetase 2, mitochondrial
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 1:151,300,446...151,412,086
Ensembl chr 1:151,300,467...151,413,521
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Dars1
aspartyl-tRNA synthetase 1
involved_in
IBA IEA
PMID:21873635 GO_REF:0000002
InterPro
PMID:21873635
GO_REF:0000002, RGD:13792537
NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116
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Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934
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Cars1
cysteinyl-tRNA synthetase 1
involved_in
ISO IBA
(PMID:10908348), (PMID:17303165) (PMID:11347887) PMID:21873635
RGD
PMID:10908348 PMID:11347887 PMID:17303165 PMID:21873635
RGD:13792537
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
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Cars2
cysteinyl-tRNA synthetase 2, mitochondrial
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr16:77,945,468...77,987,163
Ensembl chr16:77,950,008...77,987,772
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Lars1
leucyl-tRNA synthetase 1
involved_in
ISO
(PMID:26869582)
RGD
PMID:26869582
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
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Qars1
glutaminyl-tRNA synthetase 1
involved_in
IBA IEA ISS ISO
PMID:21873635 GO_REF:0000107 GO_REF:0000002 GO_REF:0000024 (PMID:24656866), (PMID:26869582)
Ensembl InterPro UniProt RGD
PMID:24656866 PMID:26869582 PMID:21873635
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107, RGD:13792537
NCBI chr 8:109,207,705...109,215,738
Ensembl chr 8:109,207,705...109,215,739
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Gatb
glutamyl-tRNA amidotransferase subunit B
involved_in
ISO IBA
(PMID:19805282) PMID:21873635
RGD
PMID:19805282 PMID:21873635
RGD:13792537
NCBI chr 2:170,930,547...171,017,133
Ensembl chr 2:170,930,542...171,016,695
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Gatc
glutamyl-tRNA amidotransferase subunit C
involved_in
IEA ISO IBA
GO_REF:0000104 (PMID:19805282) PMID:21873635
UniProt RGD
PMID:19805282 PMID:21873635
GO_REF:0000104, RGD:13792537
NCBI chr12:41,270,096...41,278,067
Ensembl chr12:41,270,087...41,277,995
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Qrsl1
glutaminyl-tRNA amidotransferase subunit QRSL1
involved_in
IBA ISO IEA
PMID:21873635 (PMID:19805282) GO_REF:0000104
RGD UniProt
PMID:19805282 PMID:21873635
GO_REF:0000104, RGD:13792537
NCBI chr20:47,357,206...47,382,160
Ensembl chr20:47,357,216...47,382,135
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Ears2
glutamyl-tRNA synthetase 2, mitochondrial
involved_in
ISO IBA
(PMID:19805282) PMID:21873635
RGD
PMID:19805282 PMID:21873635
RGD:13792537
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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Eprs1
glutamyl-prolyl-tRNA synthetase 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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Gars1
glycyl-tRNA synthetase 1
acts_upstream_of_or_within involved_in
ISO IEA
MGI:3760297 (MGI:3849224|PMID:19470612) GO_REF:0000107
RGD Ensembl
PMID:19470612
GO_REF:0000107 MGI:3849224
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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Hars1
histidyl-tRNA synthetase 1
involved_in
ISO IBA
(PMID:29235198) PMID:21873635
RGD
PMID:29235198 PMID:21873635
RGD:13792537
NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740
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Hars2
histidyl-tRNA synthetase 2, mitochondrial
involved_in
ISO IBA
(PMID:21464306) PMID:21873635
RGD
PMID:21464306 PMID:21873635
RGD:13792537
NCBI chr18:28,398,790...28,408,075
Ensembl chr18:28,398,795...28,414,747
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Zmat2
zinc finger, matrin type 2
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr18:28,409,606...28,414,241
Ensembl chr18:28,398,795...28,414,747
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Iars1
isoleucyl-tRNA synthetase 1
involved_in acts_upstream_of_or_within
IBA ISO
PMID:21873635 (PMID:8052601) (MGI:3055639|PMID:12060739)
RGD
PMID:8052601 PMID:12060739 PMID:21873635
MGI:3055639 , RGD:13792537
NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
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Iars2
isoleucyl-tRNA synthetase 2, mitochondrial
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr13:96,831,484...96,865,518
Ensembl chr13:96,831,484...96,865,501
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Lars1
leucyl-tRNA synthetase 1
involved_in
ISO IBA
(MGI:3055639|PMID:12060739) (PMID:25051973) PMID:21873635
RGD
PMID:12060739 PMID:25051973 PMID:21873635
MGI:3055639 , RGD:13792537
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
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Lars2
leucyl-tRNA synthetase 2, mitochondrial
involved_in
ISO IBA
(PMID:10684970) PMID:21873635
RGD
PMID:10684970 PMID:21873635
RGD:13792537
NCBI chr 8:123,010,271...123,106,395
Ensembl chr 8:123,010,293...123,106,395
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Kars1
lysyl-tRNA synthetase 1
involved_in
IDA IEA IBA ISO
GO_REF:0000002 PMID:21873635 (PMID:10952987), (PMID:23159739), (PMID:9278442) PMID:6315704
InterPro RGD
PMID:9278442 PMID:10952987 PMID:23159739 PMID:7372681 PMID:21873635 PMID:6315704 PMID:7082655 More...
GO_REF:0000002, RGD:2303393 , RGD:13792537 , RGD:12911009 , RGD:2303394
NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632
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Mars1
methionyl-tRNA synthetase 1
involved_in
ISO IBA
(MGI:3055639|PMID:12060739) (PMID:11714285), (PMID:33909043) PMID:21873635
RGD
PMID:11714285 PMID:12060739 PMID:33909043 PMID:21873635
MGI:3055639 , RGD:13792537
NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
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Mars2
methionyl-tRNA synthetase 2, mitochondrial
involved_in
ISO IBA
(PMID:15274629) PMID:21873635
RGD
PMID:15274629 PMID:21873635
RGD:13792537
NCBI chr 9:56,720,408...56,729,991
Ensembl chr 9:56,720,983...56,723,820
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Aars2
alanyl-tRNA synthetase 2, mitochondrial
involved_in
ISO IEA
(PMID:21549344) GO_REF:0000107
RGD Ensembl
PMID:21549344
GO_REF:0000107
NCBI chr 9:15,484,639...15,496,116
Ensembl chr 9:15,297,531...15,496,090
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Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
involved_in
ISS ISO
GO_REF:0000024 (PMID:23275545)
UniProt RGD
PMID:23275545
GO_REF:0000024
NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934
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Gars1
glycyl-tRNA synthetase 1
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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Sars2
seryl-tRNA synthetase 2, mitochondrial
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 1:84,028,972...84,040,725
Ensembl chr 1:84,028,986...84,040,725
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Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
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Yars2
tyrosyl-tRNA synthetase 2
involved_in
ISO IEA
(PMID:20598274) GO_REF:0000107
RGD Ensembl
PMID:20598274
GO_REF:0000107
NCBI chr11:84,632,350...84,638,138
Ensembl chr11:84,624,369...84,638,125
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Fars2
phenylalanyl-tRNA synthetase 2, mitochondrial
involved_in
ISS IBA IEA ISO
GO_REF:0000024 PMID:21873635 GO_REF:0000002 (PMID:10329163)
UniProt InterPro RGD
PMID:10329163 PMID:21873635
GO_REF:0000002 GO_REF:0000024, RGD:13792537
NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337
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Farsa
phenylalanyl-tRNA synthetase subunit alpha
involved_in
ISS IEA IBA ISO
GO_REF:0000024 GO_REF:0000107 PMID:21873635 GO_REF:0000002 (PMID:20223217)
UniProt Ensembl InterPro RGD
PMID:20223217 PMID:21873635
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107, RGD:13792537
NCBI chr19:23,291,409...23,300,985
Ensembl chr19:23,268,869...23,300,980
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Farsb
phenylalanyl-tRNA synthetase subunit beta
involved_in
ISO IBA
(PMID:20223217) PMID:21873635
RGD
PMID:20223217 PMID:21873635
RGD:13792537
NCBI chr 9:79,887,852...79,947,082
Ensembl chr 9:79,887,842...79,947,045
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Lrrc47
leucine rich repeat containing 47
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 5:164,570,539...164,580,174
Ensembl chr 5:164,570,435...164,580,174
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Syce2
synaptonemal complex central element protein 2
involved_in
IEA
GO_REF:0000002 GO_REF:0000107
InterPro Ensembl
GO_REF:0000002 GO_REF:0000107
NCBI chr19:23,266,236...23,291,265
Ensembl chr19:23,268,869...23,300,980
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Eprs1
glutamyl-prolyl-tRNA synthetase 1
involved_in
IBA ISO
PMID:21873635 (MGI:3055639|PMID:12060739) (PMID:24100331)
RGD
PMID:12060739 PMID:24100331 PMID:21873635
MGI:3055639 , RGD:13792537
NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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Pars2
prolyl-tRNA synthetase 2, mitochondrial
involved_in
IBA IEA
PMID:21873635 GO_REF:0000002
InterPro
PMID:21873635
GO_REF:0000002, RGD:13792537
NCBI chr 5:121,433,993...121,439,158
Ensembl chr 5:121,434,096...121,439,154
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Sars1
seryl-tRNA synthetase 1
involved_in
ISS IBA ISO IEA
GO_REF:0000024 PMID:21873635 (PMID:24095058), (PMID:28236339), (PMID:34570399), (PMID:36041817) GO_REF:0000002 GO_REF:0000107
UniProt RGD InterPro Ensembl
PMID:24095058 PMID:28236339 PMID:34570399 PMID:36041817 PMID:21873635
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107, RGD:13792537
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
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Tars1
threonyl-tRNA synthetase 1
involved_in
ISS IEA ISO IBA
GO_REF:0000024 GO_REF:0000002 GO_REF:0000107 (MGI:3055639|PMID:12060739), (MGI:6164765|PMID:29579307) PMID:21873635 (PMID:25824639)
UniProt InterPro Ensembl RGD
PMID:12060739 PMID:25824639 PMID:29579307 PMID:21873635
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:3055639 MGI:6164765 , RGD:13792537
NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717
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Tars2
threonyl-tRNA synthetase 2, mitochondrial
involved_in
IBA IEA
PMID:21873635 GO_REF:0000002
InterPro
PMID:21873635
GO_REF:0000002, RGD:13792537
NCBI chr 2:183,293,095...183,310,210
Ensembl chr 2:183,293,097...183,310,184
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Tars3
threonyl-tRNA synthetase 3
involved_in
ISO
(MGI:6164765|PMID:29579307)
RGD
PMID:29579307
MGI:6164765
NCBI chr 1:119,213,189...119,265,492
Ensembl chr 1:119,213,213...119,265,488
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Ears2
glutamyl-tRNA synthetase 2, mitochondrial
involved_in
ISO
(PMID:19805282)
RGD
PMID:19805282
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934
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ENSRNOG00000064147
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
Ensembl chr15:54,413,775...54,415,497
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ENSRNOG00000067512
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
Ensembl chr 1:232,504,645...232,506,619
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Gars1
glycyl-tRNA synthetase 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:28675565)
UniProt RGD
PMID:28675565
GO_REF:0000024
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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Wars1
tryptophanyl-tRNA synthetase 1
involved_in
IEA IBA ISO
GO_REF:0000002 PMID:21873635 (MGI:3055639|PMID:12060739), (MGI:4414690|PMID:19941862)
InterPro RGD
PMID:12060739 PMID:19941862 PMID:21873635
GO_REF:0000002 MGI:3055639 MGI:4414690 , RGD:13792537
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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Yars1
tyrosyl-tRNA synthetase 1
involved_in
IEA ISO
GO_REF:0000107 (PMID:25533949)
Ensembl RGD
PMID:25533949
GO_REF:0000107
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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Vars1
valyl-tRNA synthetase 1
involved_in
IBA IEA
PMID:21873635 GO_REF:0000002
InterPro
PMID:21873635
GO_REF:0000002, RGD:13792537
NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298
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Vars2
valyl-tRNA synthetase 2, mitochondrial
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr20:3,077,132...3,087,994
Ensembl chr20:3,077,132...3,087,994
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all