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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of macrophage activation
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Accession:GO:0043030 term browser browse the term
Definition:Any process that modulates the frequency or rate of macrophage activation.
Synonyms:exact_synonym: regulation of macrophage polarization


show annotations for term's descendants           Sort by:
regulation of macrophage activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd84 CD84 molecule involved_in ISO (PMID:20628063) RGD PMID:20628063 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076 		JBrowse link
G Gpr137b G protein-coupled receptor 137B involved_in ISO (PMID:30595385) RGD PMID:30595385 NCBI chr17:92,987,792...93,026,003
Ensembl chr17:85,966,921...86,041,835 		JBrowse link
G Mcub mitochondrial calcium uniporter dominant negative subunit beta involved_in ISO (PMID:34726954) RGD PMID:34726954 NCBI chr 2:218,479,301...218,549,594
Ensembl chr 2:218,479,301...218,549,593 		JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO
IEA 		(PMID:28471450)
GO_REF:0000107 		RGD
Ensembl		 PMID:28471450 GO_REF:0000107 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743 		JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming acts_upstream_of_or_within ISO MGI:5576290 (PMID:24317696) RGD PMID:24317696 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250 		JBrowse link
G Myo18a myosin XVIIIa involved_in ISO
IEA 		(PMID:25965346)
GO_REF:0000107 		RGD
Ensembl		 PMID:25965346 GO_REF:0000107 NCBI chr10:62,654,218...62,755,465
Ensembl chr10:62,654,281...62,755,468 		JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in ISO
IEA 		(PMID:28471450)
GO_REF:0000107 		RGD
Ensembl		 PMID:28471450 GO_REF:0000107 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISO (PMID:18511424) RGD PMID:18511424 NCBI chr10:2,104,927...2,117,998
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Pla2g5 phospholipase A2, group V acts_upstream_of_or_within ISO MGI:3042209 (PMID:24910243) RGD PMID:24910243 NCBI chr 5:156,324,628...156,393,065
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO
IEA 		MGI:1857035 (PMID:1565842)
GO_REF:0000107 		RGD
Ensembl		 PMID:1565842 GO_REF:0000107 NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
G Shpk sedoheptulokinase involved_in ISO
IEA 		(PMID:22682222)
GO_REF:0000107 		RGD
Ensembl		 PMID:22682222 GO_REF:0000107 NCBI chr10:57,817,551...57,841,981
Ensembl chr10:57,817,629...57,841,980 		JBrowse link
G Slc7a2 solute carrier family 7 member 2 involved_in ISO (PMID:16670299) RGD PMID:16670299 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784 		JBrowse link
G Snca synuclein alpha acts_upstream_of_or_within ISO
IEA 		MGI:2389489 (PMID:17035541)
GO_REF:0000107 		RGD
Ensembl		 PMID:17035541 GO_REF:0000107 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
negative regulation of macrophage activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrf5 adhesion G protein-coupled receptor F5 acts_upstream_of_or_within ISO MGI:5547987 (PMID:25778400) RGD PMID:25778400 NCBI chr 9:17,517,596...17,624,107
Ensembl chr 9:17,520,009...17,623,968 		JBrowse link
G Bpi bactericidal/permeability-increasing protein involved_in ISO
IBA 		(PMID:8409400)
GO_REF:0000033 		RGD
GO_Central		 PMID:8409400 GO_REF:0000033 NCBI chr 3:146,909,626...146,936,487
Ensembl chr 3:146,909,629...146,936,221 		JBrowse link
G Cd200 Cd200 molecule involved_in IEA
ISO 		GO_REF:0000002
(PMID:11099416) 		InterPro
RGD		 PMID:11099416 GO_REF:0000002 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648 		JBrowse link
G Cd200l1 CD200 molecule like 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:55,350,433...55,401,528
Ensembl chr11:55,336,109...55,401,373 		JBrowse link
G Cd200l2 CD200 molecule like 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:55,279,853...55,326,753
Ensembl chr11:55,280,418...55,303,827 		JBrowse link
G Fam76b family with sequence similarity 76, member B involved_in ISO
IEA 		(PMID:38421448)
GO_REF:0000107 		RGD
Ensembl		 PMID:38421448 GO_REF:0000107 NCBI chr 8:10,689,396...10,711,847
Ensembl chr 8:10,688,963...10,711,861 		JBrowse link
G Il4 interleukin 4 IMP RGD PMID:20623539 RGD:5128562 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Lrfn5 leucine rich repeat and fibronectin type III domain containing 5 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:27152329) 		UniProt
Ensembl
RGD		 PMID:27152329 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:79,466,403...79,822,821
Ensembl chr 6:79,467,961...79,822,815 		JBrowse link
G Mir130a microRNA 130a involved_in ISO (PMID:26398698) RGD PMID:26398698 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 involved_in ISO
IEA 		(PMID:21187453)
GO_REF:0000107 		RGD
Ensembl		 PMID:21187453 GO_REF:0000107 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Tff2 trefoil factor 2 acts_upstream_of_or_within ISO MGI:2179101 (PMID:17101660) RGD PMID:17101660 NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619 		JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:61,144,926...61,170,212
Ensembl chr  X:61,144,928...61,170,212 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A acts_upstream_of ISO (PMID:18178554) RGD PMID:18178554 NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
negative regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst7 cystatin F involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:5910746 (PMID:28251676) 		GO_Central
RGD		 PMID:28251676 GO_REF:0000033 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:19627440 ARUK-UCL PMID:19627440 RGD:13673772 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Grn granulin precursor involved_in ISS
ISO 		GO_REF:0000024
(PMID:23041626) 		UniProt
RGD		 PMID:23041626 GO_REF:0000024 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (PMID:20005821) 		Ensembl
RGD		 PMID:20005821 GO_REF:0000107 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:30792350)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:30792350 GO_REF:0000024 GO_REF:0000107 NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO RNAcentral:URS000024A59E_10090 (PMID:30412727) RGD PMID:30412727 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Syt11 synaptotagmin 11 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:28686317)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:28686317 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:25595455) 		GO_Central
RGD		 PMID:25595455 GO_REF:0000033 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019 		JBrowse link
positive regulation of macrophage activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO (PMID:21460847) RGD PMID:21460847 NCBI chr 2:174,721,522...174,725,029
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Cd200 Cd200 molecule involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:P21272 (PMID:26670206) 		Ensembl
RGD		 PMID:26670206 GO_REF:0000107 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha involved_in ISO
IEA 		(PMID:21131957)
GO_REF:0000107 		RGD
Ensembl		 PMID:21131957 GO_REF:0000107 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Hamp hepcidin antimicrobial peptide acts_upstream_of_or_within ISO (PMID:22383698) RGD PMID:22383698 NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO UniProtKB:O08573 (PMID:20937702) RGD PMID:20937702 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:17164250) RGD PMID:17164250 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Il10 interleukin 10 IDA RGD PMID:25837415 RGD:11049473 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il13 interleukin 13 involved_in ISO (PMID:19841166) RGD PMID:19841166 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19841166) 		Ensembl
RGD		 PMID:19841166 GO_REF:0000107 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within 		ISO (PMID:19841166)
(PMID:26936882) 		RGD PMID:19841166 PMID:26936882 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4r interleukin 4 receptor involved_in ISO (PMID:19841166) RGD PMID:19841166 NCBI chr 1:189,545,739...189,570,639
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Irgm immunity-related GTPase M involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:27439214), (PMID:27443879) 		UniProt
Ensembl
RGD		 PMID:27439214 PMID:27443879 GO_REF:0000024 GO_REF:0000107 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit IMP RGD PMID:18443593 RGD:2293336 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kars1 lysyl-tRNA synthetase 1 involved_in ISO
IEA
IBA 		(PMID:15851690)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:15851690 GO_REF:0000033 GO_REF:0000107 NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632 		JBrowse link
G Lbp lipopolysaccharide binding protein involved_in IDA
IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:8409400) 		GO_Central
Ensembl
RGD		 PMID:8409400 PMID:10733550 GO_REF:0000033 GO_REF:0000107, RGD:9685188 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lgals9 galectin 9 involved_in ISO UniProtKB:Q8VIM0 (PMID:20937702) RGD PMID:20937702 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Mir145 microRNA 145 acts_upstream_of ISO (PMID:30634164) RGD PMID:30634164 NCBI chr18:57,369,983...57,370,070
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Pla2g4a phospholipase A2 group 4A involved_in IEA
ISO 		GO_REF:0000107
(PMID:9403692), (PMID:9403693) 		Ensembl
RGD		 PMID:9403692 PMID:9403693 GO_REF:0000107 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO
IEA 		(PMID:18757424)
GO_REF:0000107 		RGD
Ensembl		 PMID:18757424 GO_REF:0000107 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO 		GO_REF:0000107
UniProtKB:Q9Y2C9 (PMID:20037584) 		Ensembl
RGD		 PMID:20037584 GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO
IEA 		UniProtKB:O00206 (PMID:20037584)
GO_REF:0000107 		RGD
Ensembl		 PMID:20037584 GO_REF:0000107 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in ISO
IEA 		(PMID:16633345)
GO_REF:0000107 		RGD
Ensembl		 PMID:16633345 GO_REF:0000107 NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265 		JBrowse link
G Ulbp1 UL16 binding protein 1 acts_upstream_of_or_within ISO (PMID:12645935) RGD PMID:12645935 NCBI chr 1:1,694,255...1,716,160 JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA 		(PMID:18174455)
GO_REF:0000107 		RGD
Ensembl		 PMID:18174455 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
positive regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C acts_upstream_of_or_within ISO
IEA 		(PMID:28251676)
GO_REF:0000107 		RGD
Ensembl		 PMID:28251676 GO_REF:0000107 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 IMP RGD PMID:21750563 RGD:329955444 NCBI chr 1:89,084,306...89,102,279
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mmp8 matrix metallopeptidase 8 acts_upstream_of ISO
IEA 		(PMID:25049354)
GO_REF:0000107 		RGD
Ensembl		 PMID:25049354 GO_REF:0000107 NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (PMID:19100238) RGD PMID:19100238 NCBI chr14:22,301,278...22,336,218
Ensembl chr14:21,952,496...21,981,245 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
(PMID:25595455) 		GO_Central
RGD		 PMID:25595455 GO_REF:0000033 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO
IBA
IEA 		(PMID:24990881)
GO_REF:0000033
(PMID:24990881), (PMID:25631124), (PMID:29752066), (PMID:30617257), (PMID:31370707)
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:24990881 PMID:25631124 PMID:29752066 PMID:30617257 PMID:31370707 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Ttbk1 tau tubulin kinase 1 involved_in ISO
IEA 		(PMID:19118186)
GO_REF:0000107 		RGD
Ensembl		 PMID:19118186 GO_REF:0000107 NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774 		JBrowse link
regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:34433553) 		UniProt
RGD		 PMID:34433553 GO_REF:0000024 NCBI chr 1:246,022,324...246,028,050
Ensembl chr 1:246,022,324...246,028,218 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 IMP rat gene in mouse model RGD PMID:17473852 RGD:5688754 NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:29662056) 		UniProt
RGD		 PMID:29662056 GO_REF:0000024 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    regulation of biological process 13398
      regulation of immune system process 1746
        regulation of leukocyte activation 609
          regulation of macrophage activation 68
            negative regulation of macrophage activation + 21
            positive regulation of macrophage activation + 32
            regulation of microglial cell activation + 19
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        regulation of multicellular organismal process 3360
          regulation of cell activation 667
            regulation of leukocyte activation 609
              regulation of macrophage activation 68
                negative regulation of macrophage activation + 21
                positive regulation of macrophage activation + 32
                regulation of microglial cell activation + 19
paths to the root