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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell homeostasis
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Accession:GO:0043029 term browser browse the term
Definition:The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
Comment:Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus.
Synonyms:exact_synonym: T lymphocyte homeostasis


show annotations for term's descendants           Sort by:
T cell homeostasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor involved_in ISO (MGI:72762|PMID:7732381) RGD PMID:7732381 MGI:72762 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aim2 absent in melanoma 2 involved_in ISO (MGI:6710169|PMID:33505023) RGD PMID:33505023 MGI:6710169 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:1197519|MGI:1857134|MGI:2156165 (MGI:2154874|PMID:11709185), (MGI:2156164|PMID:8170972), (MGI:2385423|PMID:7650488), (MGI:3760056|PMID:17591857)
GO_REF:0000107		 RGD
Ensembl		 PMID:7650488 PMID:8170972 PMID:11709185 PMID:17591857 GO_REF:0000107 MGI:2154874 MGI:2156164 MGI:2385423 MGI:3760056 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 acts_upstream_of_or_within ISO MGI:2156498|MGI:88138 (MGI:3610512|PMID:16270031), (MGI:3760056|PMID:17591857) RGD PMID:16270031 PMID:17591857 MGI:3610512 MGI:3760056 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Casp3 caspase 3 acts_upstream_of_or_within ISO MGI:2178778 (MGI:2677082|PMID:12970760) RGD PMID:12970760 MGI:2677082 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb2 cyclin B2 acts_upstream_of_or_within ISO MGI:2429974 (MGI:1203433|PMID:9539739) RGD PMID:9539739 MGI:1203433 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Chst3 carbohydrate sulfotransferase 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2176247 (MGI:2156294|PMID:11696535)
GO_REF:0000107		 RGD
Ensembl		 PMID:11696535 GO_REF:0000107 MGI:2156294 NCBI chr20:28,114,386...28,152,046
Ensembl chr20:28,114,404...28,121,807 		JBrowse link
G Coro1a coronin 1A acts_upstream_of_or_within ISO MGI:3664599 (MGI:3654559|PMID:16902139) RGD PMID:16902139 MGI:3654559 NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534 		JBrowse link
G Fadd Fas associated via death domain involved_in ISS
ISO		 GO_REF:0000024
(MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor acts_upstream_of_or_within ISO MGI:1856384 (MGI:79355|PMID:8640868) RGD PMID:8640868 MGI:79355 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Foxn1 forkhead box N1 involved_in ISO (MGI:5554515|PMID:24184560) RGD PMID:24184560 MGI:5554515 NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15328390 RGD:1303374 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Gpr15lg G protein-coupled receptor 15 ligand involved_in ISO (PMID:28900043) RGD PMID:28900043 NCBI chr16:12,868,270...12,875,876
Ensembl chr16:12,868,270...12,875,876 		JBrowse link
G Gpr174 G protein-coupled receptor 174 acts_upstream_of_or_within ISO MGI:5644336 (MGI:5644334|PMID:26077720) RGD PMID:26077720 MGI:5644334 NCBI chr  X:72,355,452...72,396,146
Ensembl chr  X:72,355,033...72,397,658 		JBrowse link
G Il20rb interleukin 20 receptor subunit beta acts_upstream_of_or_within ISO MGI:3830304 (MGI:3827040|PMID:19124723) RGD PMID:19124723 MGI:3827040 NCBI chr 8:100,979,085...101,010,829
Ensembl chr 8:100,980,383...101,009,942 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1857192 (MGI:2670301|PMID:12702495) RGD PMID:12702495 MGI:2670301 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il7r interleukin 7 receptor acts_upstream_of_or_within ISO MGI:1857198 (MGI:893318|PMID:9215624), (MGI:893320|PMID:9215626) RGD PMID:9215624 PMID:9215626 MGI:893318 MGI:893320 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3655405|PMID:9498750)		 BHF-UCL
RGD		 PMID:9498750 GO_REF:0000024 MGI:3655405 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Lgals2 galectin 2 involved_in ISO
IEA		 (PMID:15356130)
GO_REF:0000107		 RGD
Ensembl		 PMID:15356130 GO_REF:0000107 NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISS
ISO		 GO_REF:0000024
(MGI:3818191|PMID:19015308)		 UniProt
RGD		 PMID:19015308 GO_REF:0000024 MGI:3818191 NCBI chr 7:134,577,470...134,622,928
Ensembl chr 7:134,577,482...134,622,934 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:3664807|PMID:16116196) RGD PMID:16116196 MGI:3664807 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO
IEA		 (MGI:3795821|PMID:18411339)
GO_REF:0000107		 RGD
Ensembl		 PMID:18411339 GO_REF:0000107 MGI:3795821 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in ISS
ISO		 GO_REF:0000024
(MGI:6142003|PMID:26974206)		 UniProt
RGD		 PMID:26974206 GO_REF:0000024 MGI:6142003 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha involved_in ISO (MGI:6142003|PMID:26974206) RGD PMID:26974206 MGI:6142003 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 PMID:21873635
GO_REF:0000107
MGI:3759678 (MGI:3589325|PMID:16129705)		 Ensembl
RGD		 PMID:16129705 PMID:21873635 GO_REF:0000107 MGI:3589325, RGD:13792537 NCBI chr 6:72,647,025...72,670,885
Ensembl chr 6:72,647,025...72,672,491 		JBrowse link
G Ppp3cb protein phosphatase 3 catalytic subunit beta acts_upstream_of_or_within ISO MGI:2181294 (MGI:3772519|PMID:18097009) RGD PMID:18097009 MGI:3772519 NCBI chr15:3,759,950...3,804,976
Ensembl chr15:3,760,030...3,804,981 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2668456 (MGI:3050700|PMID:15259009)
GO_REF:0000107		 RGD
Ensembl		 PMID:15259009 GO_REF:0000107 MGI:3050700 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Rag1 recombination activating 1 acts_upstream_of_or_within ISO MGI:1353616 (MGI:3811961|PMID:18684012) RGD PMID:18684012 MGI:3811961 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO MGI:2442789 (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO MGI:2685397 (MGI:5486592|PMID:23583643) RGD PMID:23583643 MGI:5486592 NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q61160 (MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Sit1 signaling threshold regulating transmembrane adaptor 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:57,740,212...57,741,838
Ensembl chr 5:57,740,218...57,741,838 		JBrowse link
G Slc39a3 solute carrier family 39 member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:3512105 (MGI:3624433|PMID:16652366)
GO_REF:0000107		 RGD
Ensembl		 PMID:16652366 GO_REF:0000107 MGI:3624433 NCBI chr 7:8,676,845...8,682,846
Ensembl chr 7:8,676,759...8,685,149 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 acts_upstream_of_or_within ISO MGI:97848 (MGI:3811961|PMID:18684012) RGD PMID:18684012 MGI:3811961 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate acts_upstream_of_or_within ISO MGI:4460276|MGI:5426392|MGI:5442804 (MGI:5424314|PMID:22406534), (MGI:5442641|PMID:22664872) RGD PMID:22406534 PMID:22664872 MGI:5424314 MGI:5442641 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO MGI:103035 (MGI:1332382|PMID:10072077) RGD PMID:10072077 MGI:1332382 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:103036 (MGI:1332382|PMID:10072077)		 Ensembl
RGD		 PMID:10072077 GO_REF:0000107 MGI:1332382 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO (MGI:5470331|PMID:23166162) RGD PMID:23166162 MGI:5470331 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:3719583 (MGI:3718815|PMID:17481928) RGD PMID:17481928 MGI:3718815 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Zc3h8 zinc finger CCCH type containing 8 involved_in ISO (PMID:12153508) RGD PMID:12153508 NCBI chr 3:116,176,779...116,193,752
Ensembl chr 3:116,176,798...116,193,787 		JBrowse link
activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14749367)
GO_REF:0000107		 RGD
Ensembl		 PMID:14749367 GO_REF:0000107 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 acts_upstream_of_or_within ISO MGI:2448686|MGI:3040717 (MGI:3580938|PMID:15879105) RGD PMID:15879105 MGI:3580938 NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161 		JBrowse link
G Fas Fas cell surface death receptor involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:1856334|MGI:1856384 (MGI:2670301|PMID:12702495), (MGI:73864|PMID:7602121), (MGI:79355|PMID:8640868)		 RGD PMID:7602121 PMID:8640868 PMID:12702495 PMID:21873635 MGI:2670301 MGI:73864 MGI:79355, RGD:13792537 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial acts_upstream_of
involved_in		 ISO
IEA		 MGI:2669956 (MGI:3826295|PMID:18971390)
GO_REF:0000107		 RGD
Ensembl		 PMID:18971390 GO_REF:0000107 MGI:3826295 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1857192 (MGI:1889048|PMID:7584142) RGD PMID:7584142 MGI:1889048 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Rps6 ribosomal protein S6 acts_upstream_of_or_within ISO MGI:2387471 (MGI:3610868|PMID:16357222) RGD PMID:16357222 MGI:3610868 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO (PMID:16491128) RGD PMID:16491128 NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of ISO (MGI:67124|PMID:8206089) RGD PMID:8206089 MGI:67124 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
negative regulation of activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fadd Fas associated via death domain involved_in ISS
ISO		 GO_REF:0000024
(MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2669956 (MGI:3826295|PMID:18971390)		 Ensembl
RGD		 PMID:18971390 GO_REF:0000107 MGI:3826295 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639 		JBrowse link
G Tnfrsf4 TNF receptor superfamily member 4 involved_in ISO (MGI:2150820|PMID:11567634) RGD PMID:11567634 MGI:2150820 NCBI chr 5:166,606,909...166,609,599
Ensembl chr 5:166,606,909...166,609,599 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (MGI:1101744|PMID:9430225)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:9430225 PMID:21873635 GO_REF:0000107 MGI:1101744, RGD:13792537 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861 		JBrowse link
negative regulation of T cell homeostatic proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (MGI:3721471|PMID:16769998) RGD PMID:16769998 MGI:3721471 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
positive regulation of activated T cell autonomous cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
positive regulation of activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO MGI:5609428 (MGI:5451119|PMID:23123061) RGD PMID:23123061 MGI:5451119 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 acts_upstream_of_or_within ISO (MGI:67124|PMID:8206089) RGD PMID:8206089 MGI:67124 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
positive regulation of T cell homeostatic proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd24 CD24 molecule acts_upstream_of_or_within ISO MGI:2179996 (MGI:3510302|PMID:15477346) RGD PMID:15477346 MGI:3510302 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
regulation of activation-induced cell death of T cells term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
ISO		 GO_REF:0000024
UniProtKB:Q61160 (MGI:5291865|PMID:21876153)		 UniProt
RGD		 PMID:21876153 GO_REF:0000024 MGI:5291865 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
regulation of T cell homeostatic proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 acts_upstream_of_or_within ISO MGI:1857191 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha acts_upstream_of_or_within ISO MGI:1857192 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Lmo1 LIM domain only 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:50590|PMID:1508213)		 Ensembl
RGD		 PMID:1508213 GO_REF:0000107 MGI:50590 NCBI chr 1:163,132,338...163,168,521
Ensembl chr 1:163,132,339...163,168,522 		JBrowse link
T cell homeostatic proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO MGI:1857429 (MGI:76784|PMID:7569956), (MGI:894988|PMID:9241272) RGD PMID:7569956 PMID:9241272 MGI:76784 MGI:894988 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Cd24 CD24 molecule acts_upstream_of ISO MGI:2179996 (MGI:3510302|PMID:15477346) RGD PMID:15477346 MGI:3510302 NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    immune system process 2665
      leukocyte homeostasis 138
        lymphocyte homeostasis 93
          T cell homeostasis 54
            T cell homeostatic proliferation + 5
            activated T cell autonomous cell death + 1
            activation-induced cell death of T cells + 13
Path 2
Term Annotations click to browse term
  biological_process 19574
    multicellular organismal process 9171
      multicellular organismal-level homeostasis 941
        homeostasis of number of cells 401
          leukocyte homeostasis 138
            lymphocyte homeostasis 93
              T cell homeostasis 54
                T cell homeostatic proliferation + 5
                activated T cell autonomous cell death + 1
                activation-induced cell death of T cells + 13
paths to the root