Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:amyloid precursor protein catabolic process
go back to main search page
Accession:GO:0042987 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease.
Synonyms:exact_synonym: APP catabolic process;   APP catabolism;   amyloid precursor protein breakdown;   amyloid precursor protein catabolism;   amyloid precursor protein degradation


show annotations for term's descendants           Sort by:
amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in ISO
IEA		 (PMID:28164773)
GO_REF:0000107		 RGD
Ensembl		 PMID:28164773 GO_REF:0000107 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO
IEA		 (PMID:9774383)
GO_REF:0000107		 RGD
Ensembl		 PMID:9774383 GO_REF:0000107 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 involved_in ISO (PMID:17112471) RGD PMID:17112471 NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,491,405...30,583,105 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 involved_in ISO (PMID:12054541) RGD PMID:12054541 NCBI chr16:73,725,186...73,804,284
Ensembl chr16:67,022,655...67,100,917 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:15274632), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:15274632 PMID:27608597 NCBI chr 2:186,123,023...186,130,886
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597) RGD PMID:12763021 PMID:27608597 NCBI chr 8:76,310,380...76,334,146
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Bace1 beta-secretase 1 involved_in ISO
IEA		 UniProtKB:Q9BZC7 (PMID:20704561)
GO_REF:0000107		 RGD
Ensembl		 PMID:20704561 GO_REF:0000107 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10924275) RGD PMID:10924275 NCBI chr 1:190,586,649...190,600,034
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO
IEA		 MGI:3027024 (PMID:16407971)
GO_REF:0000107		 RGD
Ensembl		 PMID:16407971 GO_REF:0000107 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Ncstn nicastrin involved_in ISO
IEA		 UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:15274632), (PMID:27608597)
GO_REF:0000107		 RGD
Ensembl		 PMID:12763021 PMID:15274632 PMID:27608597 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:27608597)
GO_REF:0000107
GO_REF:0000002
MGI:2149116|MGI:2179062|MGI:2449304 (PMID:10206645), (PMID:11567612), (PMID:15452145)		 RGD
Ensembl
InterPro		 PMID:10206645 PMID:11567612 PMID:12297508 PMID:12763021 PMID:15452145 More... GO_REF:0000002 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO
IEA		 (PMID:27608597)
GO_REF:0000107
GO_REF:0000002		 RGD
Ensembl
InterPro		 PMID:27608597 GO_REF:0000002 GO_REF:0000107 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISO
IEA		 UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:15274632)
GO_REF:0000107		 RGD
Ensembl		 PMID:12660785 PMID:12763021 PMID:15274632 GO_REF:0000107 NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS		 (PMID:26260791)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 involved_in IMP PMID:17301176 SynGO-UCL PMID:17301176 RGD:12907557 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597) RGD PMID:12297508 PMID:12763021 PMID:25043039 PMID:26280335 PMID:27608597 NCBI chr 2:186,123,023...186,130,886
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit involved_in
acts_upstream_of_or_within		 ISO UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:27608597)
MGI:1202717|MGI:1891700 (PMID:16371134)		 RGD PMID:12763021 PMID:16371134 PMID:27608597 NCBI chr 8:76,310,380...76,334,146
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA		 (PMID:27992182)
GO_REF:0000107		 RGD
Ensembl		 PMID:27992182 GO_REF:0000107 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Bace1 beta-secretase 1 involved_in ISO
IEA		 (PMID:24352696)
GO_REF:0000107		 RGD
Ensembl		 PMID:24352696 GO_REF:0000107 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Ncstn nicastrin involved_in
acts_upstream_of_or_within		 ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
MGI:1202717|MGI:3522097 (PMID:16371134)
UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335), (PMID:27608597)		 UniProt
Ensembl
RGD		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:25043039 PMID:26280335 More... GO_REF:0000024 GO_REF:0000107 NCBI chr13:87,062,827...87,078,839
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA
ISS		 UniProtKB:P05067 (PMID:12297508), (PMID:12763021), (PMID:26280335), (PMID:27608597)
GO_REF:0000107
MGI:1891700|MGI:2149116|MGI:3522097 (PMID:16371134), (PMID:20130175)
GO_REF:0000033
GO_REF:0000024		 RGD
Ensembl
GO_Central
UniProt		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:20130175 PMID:26280335 More... GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO
IEA
IBA		 (PMID:27608597)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:27608597 GO_REF:0000033 GO_REF:0000107 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (PMID:12660785), (PMID:12763021), (PMID:25043039), (PMID:26280335)		 UniProt
Ensembl
RGD		 PMID:12660785 PMID:12763021 PMID:25043039 PMID:26280335 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:94,942,348...94,943,545
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO
IEA		 (PMID:24612608)
GO_REF:0000107		 RGD
Ensembl		 PMID:24612608 GO_REF:0000107 NCBI chr10:63,424,084...63,445,811
Ensembl chr10:62,920,665...62,947,756 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:109,098,831...109,098,911
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Prnp prion protein involved_in ISO
IEA		 UniProtKB:P12023 (PMID:17573534)
GO_REF:0000107		 RGD
Ensembl		 PMID:17573534 GO_REF:0000107 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA		 (PMID:24305806), (PMID:27853422)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO
IEA		 (PMID:16407538), (PMID:17855360), (PMID:21989385)
GO_REF:0000107
(PMID:18362153)		 RGD
Ensembl		 PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 GO_REF:0000107 NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18429932), (PMID:23467355), (PMID:27030769)		 Alzheimers_University_of_Toronto
RGD		 PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:24154541)
(PMID:24259049)
GO_REF:0000107		 RGD
Ensembl		 PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA		 (PMID:27179792)
GO_REF:0000107		 RGD
Ensembl		 PMID:27179792 GO_REF:0000107 NCBI chr18:24,282,840...24,341,461
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)		 Alzheimers_University_of_Toronto
Ensembl
RGD		 PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO
IEA		 (PMID:17553422)
GO_REF:0000107		 RGD
Ensembl		 PMID:17553422 GO_REF:0000107 NCBI chr10:101,324,378...101,342,373
Ensembl chr10:100,825,426...100,844,462 		JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,778,267...85,786,553
Ensembl chr10:85,277,890...85,286,126 		JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA		 RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107		 RGD
Ensembl		 PMID:27277332 GO_REF:0000107 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Mir103a1 microRNA 103a-1 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr10:20,748,474...20,748,559
Ensembl chr10:20,244,412...20,244,497 		JBrowse link
G Mir103a2 microRNA 103a-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 3:138,963,227...138,963,312
Ensembl chr 3:118,510,194...118,510,279 		JBrowse link
G Mir153 microRNA 153 involved_in ISO (PMID:22733824) RGD PMID:22733824 NCBI chr 6:144,306,594...144,306,680
Ensembl chr 6:138,163,595...138,163,681 		JBrowse link
G Mir15b microRNA 15b acts_upstream_of ISO (PMID:29961672) RGD PMID:29961672 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir16-2 microRNA 16-2 acts_upstream_of ISO (PMID:27343180) RGD PMID:27343180 NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:153,245,349...153,245,443 		JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr 2:249,241,650...249,241,735
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Mir24-2 microRNA 24-2 acts_upstream_of ISO (PMID:25100943) RGD PMID:25100943 NCBI chr19:40,859,455...40,859,562
Ensembl chr19:23,954,683...23,954,790 		JBrowse link
G Mir298 microRNA 298 acts_upstream_of ISO (PMID:31942037) RGD PMID:31942037 NCBI chr 3:183,470,522...183,470,603
Ensembl chr 3:163,052,291...163,052,372 		JBrowse link
G Mir29a microRNA 29a acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 acts_upstream_of ISO (PMID:18434550) RGD PMID:18434550 NCBI chr13:109,098,831...109,098,911
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir339 microRNA 339 acts_upstream_of ISO (PMID:24352696) RGD PMID:24352696 NCBI chr12:20,391,395...20,391,490
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir361 microRNA 361 involved_in ISO (PMID:31601077) RGD PMID:31601077 NCBI chr  X:82,438,463...82,438,532
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Mir455 microRNA 455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) RGD PMID:25100943 PMID:31181293 NCBI chr 5:81,704,834...81,704,911
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within ISO
IEA		 UniProtKB:P05067-4 (PMID:26094765)
GO_REF:0000107		 RGD
Ensembl		 PMID:26094765 GO_REF:0000107 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819)		 RGD PMID:16554819 PMID:25576397 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Prnp prion protein involved_in ISO
IEA		 UniProtKB:P12023 (PMID:17573534)
GO_REF:0000107		 RGD
Ensembl		 PMID:17573534 GO_REF:0000107 NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA		 (PMID:24305806), (PMID:27853422)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571 		JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15286784)		 UniProt
Ensembl
RGD		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:96,499,137...96,719,340
Ensembl chr 6:90,763,216...90,983,436 		JBrowse link
G Rtn2 reticulon 2 involved_in ISO
IEA
ISS		 (PMID:15286784)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:88,063,124...88,076,082
Ensembl chr 1:78,935,104...78,948,069 		JBrowse link
G Rtn3 reticulon 3 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15286784)		 UniProt
Ensembl
RGD		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:214,041,838...214,098,644
Ensembl chr 1:204,612,675...204,669,275 		JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS		 (PMID:15286784)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:107,651,001...107,698,610
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO
IEA		 (PMID:18362153), (PMID:19036982)
GO_REF:0000107
(PMID:16174740), (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)		 RGD
Ensembl		 PMID:16174740 PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 More... GO_REF:0000107 NCBI chr 8:51,238,713...51,401,458
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within ISO
IEA		 (PMID:16227578)
GO_REF:0000107		 RGD
Ensembl		 PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) RGD PMID:27179792 NCBI chr18:24,282,840...24,341,461
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) RGD PMID:16641999 NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:104,991,838...105,026,753 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO
IEA		 UniProtKB:P56818 (PMID:20704561), (PMID:22086926)
GO_REF:0000107		 RGD
Ensembl		 PMID:20704561 PMID:22086926 GO_REF:0000107 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA		 UniProtKB:P05067-PRO_0000000093 (PMID:22406537)
GO_REF:0000107		 RGD
Ensembl		 PMID:22406537 GO_REF:0000107 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G App amyloid beta precursor protein involved_in ISO UniProtKB:Q15109 (PMID:22406537) RGD PMID:22406537 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Efna1 ephrin A1 involved_in ISO
IEA		 UniProtKB:P54764 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Efna3 ephrin A3 involved_in ISO UniProtKB:P54764 (PMID:24217950) RGD PMID:24217950 NCBI chr 2:177,026,928...177,035,838
Ensembl chr 2:174,729,764...174,738,736 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO
IEA		 UniProtKB:P20827|UniProtKB:P52797 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO
IEA		 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 5:21,437,127...21,553,097
Ensembl chr 5:16,639,466...16,756,868 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22539346)
GO_REF:0000107		 Alzheimers_University_of_Toronto
RGD
Ensembl		 PMID:22539346 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of IGI PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr17:21,426,717...21,508,964
Ensembl chr17:21,220,618...21,303,004 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO
IEA		 (PMID:24305806)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 GO_REF:0000107 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within ISO
IEA		 (PMID:16227578)
GO_REF:0000107		 RGD
Ensembl		 PMID:16227578 GO_REF:0000107 NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA
IMP		 (PMID:22086926)
GO_REF:0000107		 RGD
Ensembl		 PMID:22086926 PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:28,642,660...28,662,689
Ensembl chr 3:8,244,639...8,264,537 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541 PMID:24259049 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Casp3 caspase 3 involved_in IDA
IEA
ISO		 PMID:17553422
GO_REF:0000107
(PMID:17553422)		 Ensembl
RGD		 PMID:17553422 PMID:17553422 GO_REF:0000107, RGD:13825190 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P05067 (PMID:20164328)		 Ensembl
RGD		 PMID:20164328 GO_REF:0000107 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:12145324)
GO_REF:0000024		 Ensembl
RGD
Alzheimers_University_of_Toronto		 PMID:12145324 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:112,863,726...112,887,338
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Efna1 ephrin A1 involved_in ISO
IEA		 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Epha4 Eph receptor A4 involved_in ISO
IEA		 UniProtKB:P20827 (PMID:24217950)
GO_REF:0000107		 RGD
Ensembl		 PMID:24217950 GO_REF:0000107 NCBI chr 9:86,263,982...86,406,744
Ensembl chr 9:78,815,460...78,958,139 		JBrowse link
G Gsap gamma-secretase activating protein involved_in ISO
IEA
IBA		 (PMID:20811458)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:20811458 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:14,705,237...14,800,057
Ensembl chr 4:13,813,046...13,907,814 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO UniProtKB:P49841 (PMID:12761548) RGD PMID:12761548 NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (PMID:17255335)		 RGD PMID:17255335 PMID:19808651 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO UniProtKB:P01579|UniProtKB:P05067 (PMID:17255335) RGD PMID:17255335 NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO
IEA		 (PMID:17098871)
GO_REF:0000107		 RGD
Ensembl		 PMID:17098871 GO_REF:0000107 NCBI chr20:24,514,304...24,688,322
Ensembl chr20:24,515,627...24,689,669 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:27277332) RGD PMID:27277332 NCBI chr 9:30,590,697...30,590,780
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
ISS
IEA		 (PMID:24577224)
(PMID:22539346), (PMID:24577224)
GO_REF:0000024
GO_REF:0000107		 RGD
Alzheimers_University_of_Toronto
Ensembl		 PMID:22539346 PMID:24577224 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO
IEA		 (PMID:21329555)
GO_REF:0000107		 RGD
Ensembl		 PMID:21329555 GO_REF:0000107 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 involved_in ISO
IEA		 (PMID:24305806)
GO_REF:0000107		 RGD
Ensembl		 PMID:24305806 GO_REF:0000107 NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO
IEA		 UniProtKB:P05067-4 (PMID:26094765)
GO_REF:0000107		 RGD
Ensembl		 PMID:26094765 GO_REF:0000107 NCBI chr 7:124,278,881...124,606,146
Ensembl chr 7:122,399,330...122,726,605 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO
IEA		 (PMID:14701757)
GO_REF:0000107		 RGD
Ensembl		 PMID:14701757 GO_REF:0000107 NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) RGD PMID:17255335 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO
IEA
ISS		 (PMID:26260791)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:26260791 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:10,342,092...10,362,094
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA		 (PMID:28164773)
GO_REF:0000107		 RGD
Ensembl		 PMID:28164773 GO_REF:0000107 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO UniProtKB:P05067 (PMID:24499793) RGD PMID:24499793 NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24577224)		 Alzheimers_University_of_Toronto
Ensembl
RGD		 PMID:24577224 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) RGD PMID:23070049 NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,336,229...18,381,872 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA
ISO		 GO_REF:0000107
(PMID:25556849)		 Ensembl
RGD		 PMID:25556849 GO_REF:0000107 NCBI chr11:47,360,824...47,479,033
Ensembl chr11:33,890,490...34,009,420 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO UniProtKB:P05067-PRO_0000000092 (PMID:26005850) RGD PMID:26005850 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:144,056,721...144,137,557 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO
IEA
ISS		 (PMID:16641999)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16641999 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:104,991,838...105,026,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    cellular process 19550
      metabolic process 12180
        primary metabolic process 10745
          protein metabolic process 5212
            amyloid precursor protein metabolic process 95
              amyloid precursor protein catabolic process 74
                amyloid-beta formation + 61
                negative regulation of amyloid precursor protein catabolic process + 34
                positive regulation of amyloid precursor protein catabolic process + 27
                regulation of amyloid precursor protein catabolic process + 60
paths to the root